4-Bromo-1H-indole-2-carbonitrile
- Product Name
- 4-Bromo-1H-indole-2-carbonitrile
- CAS No.
- 955978-74-2
- Chemical Name
- 4-Bromo-1H-indole-2-carbonitrile
- Synonyms
- 4-Bromo-1H-indole-2-carbonitrile;1H-Indole-2-carbonitrile, 4-bromo-
- CBNumber
- CB02471589
- Molecular Formula
- C9H5BrN2
- Formula Weight
- 221.05
- MOL File
- 955978-74-2.mol
4-Bromo-1H-indole-2-carbonitrile Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C9H5BrN2/c10-8-2-1-3-9-7(8)4-6(5-11)12-9/h1-4,12H
- InChIKey
- XFDNTTNQXSIPDZ-UHFFFAOYSA-N
- SMILES
- N1C2=C(C(Br)=CC=C2)C=C1C#N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 6478AC
- Product name
- 4-Bromo-1H-indole-2-carbonitrile
- Packaging
- 100mg
- Price
- $211
- Updated
- 2021/12/16
- Product number
- 089820
- Product name
- 4-Bromo-1H-indole-2-carbonitrile
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $492
- Updated
- 2021/12/16
- Product number
- HCH0365506
- Product name
- 4-BROMO-1H-INDOLE-2-CARBONITRILE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.69
- Updated
- 2021/12/16
- Product number
- 6478AC
- Product name
- 4-Bromo-1H-indole-2-carbonitrile
- Packaging
- 1g
- Price
- $690
- Updated
- 2021/12/16
- Product number
- 089820
- Product name
- 4-Bromo-1H-indole-2-carbonitrile
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1092
- Updated
- 2021/12/16
4-Bromo-1H-indole-2-carbonitrile Chemical Properties,Usage,Production
Synthesis
955978-73-1
955978-74-2
General procedure for the synthesis of 4-bromo-1H-indole-2-carboxamide from 4-bromo-1H-indole-2-carbonitrile: 1. 4-Bromo-1H-indole-2-carboxamide (207.3 mg, 0.87 mmol) was dissolved in ethyl acetate (8 mL) in a microwave vial. 2. To the above solution was added a 50% ethyl acetate solution (0.630 mL, 1.06 mmol) of 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphine-2,4,6-trioxide. 3. The vial was sealed and the mixture was placed in a microwave reactor and stirred at 100 °C for 1.5 hours. 4. reseal the vial and continue stirring in the microwave reactor at 100 °C for 2 hours. 5. A 50% ethyl acetate solution (0.250 mL, 0.42 mmol) of 2,4,6-tripropyl-1,3,5,2,4,6-trioxatriphosphine-2,4,6-trioxide was added again, the vial was resealed, and stirring was continued at 100 °C for 3.5 hours. 6. Upon completion of the reaction, water (10 mL) was added to the reaction mixture for stratification. 7. The aqueous layer was extracted with ethyl acetate (2 x 10 mL), the organic layers were combined and filtered through a cartridge containing hydrophobic glass material. 8. The filtrate was evaporated under vacuum to give a light yellow crystalline solid. 9. The solid was redissolved in DMSO (2 mL) and purified by MDAP (high pH). 10. The collected grades were evaporated under a stream of nitrogen, redissolved in methanol (~2 mL) and combined. 11. The solution was evaporated under a stream of nitrogen and the residue was vacuum dried to afford the target product 4-bromo-1H-indole-2-carbonitrile (145.0 mg, 0.66 mmol, 76% yield) as a glassy white solid. 12. LCMS (2 min high pH) analysis: retention time Rt = 1.14 min, [M-H]? = 219.0.
References
[1] Patent: WO2009/53715, 2009, A1. Location in patent: Page/Page column 55
[2] Patent: WO2007/122410, 2007, A1. Location in patent: Page/Page column 68
[3] Patent: WO2008/125835, 2008, A1. Location in patent: Referential example 18
[4] Patent: WO2017/174621, 2017, A1. Location in patent: Page/Page column 89
4-Bromo-1H-indole-2-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
4-Bromo-1H-indole-2-carbonitrile Suppliers
- Tel
- 028-83133020 18280298385
- 1223808415@qq.com
- Country
- China
- ProdList
- 511
- Advantage
- 58
- Tel
- 027-86697669 13986148687
- Fax
- 86-027-86697669
- sales@tcaschem.com
- Country
- China
- ProdList
- 4131
- Advantage
- 55
- Tel
- 021-54849683 13601642561
- Fax
- +86-21-54375689
- sales@keepontech.com
- Country
- China
- ProdList
- 998
- Advantage
- 59
- Tel
- 02161555100
- Fax
- -
- Country
- China
- ProdList
- 820
- Advantage
- 58
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 025-58859352 18068836627
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 15083
- Advantage
- 58
- Tel
- 15026866316
- 180642609@qq.com
- Country
- China
- ProdList
- 4967
- Advantage
- 58
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- 027-69573188 18221423799
- 1503407886@qq.com
- Country
- China
- ProdList
- 1439
- Advantage
- 58
- Tel
- +86-27-50766799 +8618062016861
- contact@labnetwork.com
- Country
- China
- ProdList
- 19987
- Advantage
- 58