1-(4-chloro-2-nitrophenyl)ethanone
- Product Name
- 1-(4-chloro-2-nitrophenyl)ethanone
- CAS No.
- 23082-51-1
- Chemical Name
- 1-(4-chloro-2-nitrophenyl)ethanone
- Synonyms
- 4'-Chloro-2'-nitroacetophenone;1-(4-chloro-2-nitrophenyl)ethanone;1-(4-chloro-2-nitrophenyl)ethan-1-one;Ethanone, 1-(4-chloro-2-nitrophenyl)-
- CBNumber
- CB02473664
- Molecular Formula
- C8H6ClNO3
- Formula Weight
- 199.59
- MOL File
- 23082-51-1.mol
1-(4-chloro-2-nitrophenyl)ethanone Property
- Melting point:
- 55-56℃
- Boiling point:
- 157°C/9mmHg(lit.)
- Density
- 1.378
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- color
- White to Orange to Green
- CAS DataBase Reference
- 23082-51-1
Safety
- HS Code
- 2914790090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- C3308
- Product name
- 4'-Chloro-2'-nitroacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $47
- Updated
- 2026/03/19
- Product number
- C596865
- Product name
- 1-(4-Chloro-2-nitrophenyl)ethanone
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- Z4457
- Product name
- 1-(4-Chloro-2-nitrophenyl)ethanone
- Packaging
- 5g
- Price
- $408
- Updated
- 2021/12/16
- Product number
- HCH0351325
- Product name
- 1-(4-CHLORO-2-NITROPHENYL)ETHANONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.54
- Updated
- 2021/12/16
- Product number
- A132829
- Product name
- 1-(4-Chloro-2-nitrophenyl)ethanone
- Purity
- 98%
- Packaging
- 100mg
- Price
- $19
- Updated
- 2021/12/16
1-(4-chloro-2-nitrophenyl)ethanone Chemical Properties,Usage,Production
Chemical Properties
Off-white, free-flowing granules.Soluble in chlorinated solvents; insoluble in water.
Uses
Bacteriostat and fungistat in cutting oils, water systems, paint, plastics, textiles; chemical intermediate.
Synthesis
41995-04-4
105-53-3
23082-51-1
Sodium hydride (NaH, 3.6 g, 90 mmol) was added to a tetrahydrofuran (THF, 250 mL) solution of diethyl malonate (12.0 g, 75 mmol) in batches and the reaction mixture was stirred for 20 min at room temperature. Subsequently, a tetrahydrofuran (THF, 100 mL) solution of 4-chloro-2-nitrobenzoyl chloride was slowly added dropwise into the reaction system at 0 °C. After the dropwise addition, stirring was continued for 30 min at room temperature, and then the reaction was warmed up to 80 °C for 2 h. The reaction was carried out at 0 °C for 2 h. The reaction was carried out at 0 °C for 2 h. Upon completion of the reaction, the reaction was quenched with water and extracted with ethyl acetate and water by partitioning. The organic phase was collected, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The concentrated residue was dissolved in a mixed solution of acetic acid (AcOH, 25 mL) and 20% sulfuric acid (H2SO4, 25 mL), and the reaction was stirred at 80 °C for 6 hours. At the end of the reaction, the reaction mixture was extracted with ethyl acetate and the organic phase was washed sequentially with saturated saline, water and sodium bicarbonate (NaHCO3) solution. The organic phase was dried again with anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. Finally, the residue was purified by silica gel fast column chromatography (eluent: ethyl acetate/petroleum ether=1:5) to afford the target product 1-(4-chloro-2-nitrophenyl)ethanone (5.0 g, 33% yield) as a light yellow solid.
References
[1] Patent: WO2015/54572, 2015, A1. Location in patent: Page/Page column 274
[2] Chemical and Pharmaceutical Bulletin, 1969, vol. 17, p. 596 - 604
[3] Patent: US2008/287458, 2008, A1. Location in patent: Page/Page column 39
1-(4-chloro-2-nitrophenyl)ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
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