2,3-Dichloro-4-iodopyridine
- Product Name
- 2,3-Dichloro-4-iodopyridine
- CAS No.
- 889865-45-6
- Chemical Name
- 2,3-Dichloro-4-iodopyridine
- Synonyms
- 2,3-Dichloro-4-iodopyridine;2,3-dichlorine-4-iodopyridine;Pyridine, 2,3-dichloro-4-iodo-;2,3-Dichloro-4-iodopyridine 97%;2,3-Dichloro-4-iodopyridine ISO 9001：2015 REACH
- CBNumber
- CB02478513
- Molecular Formula
- C5H2Cl2IN
- Formula Weight
- 273.89
- MOL File
- 889865-45-6.mol
2,3-Dichloro-4-iodopyridine Property
- Melting point:
- 109-113°C
- Boiling point:
- 284.3±35.0 °C(Predicted)
- Density
- 2.129±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- form
- solid
- pka
- -0.80±0.10(Predicted)
- color
- Cream
- InChIKey
- WRPBPDPXVUBWCR-UHFFFAOYSA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H319Causes serious eye irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 730564
- Product name
- 2,3-Dichloro-4-iodopyridine
- Purity
- 97%
- Packaging
- 1g
- Price
- $76.4
- Updated
- 2023/01/07
- Product number
- D438433
- Product name
- 2,3-Dichloro-4-iodopyridine
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- D15687
- Product name
- 2,3-Dichloro-4-iodopyridine
- Packaging
- 1g
- Price
- $18
- Updated
- 2021/12/16
- Product number
- 035736
- Product name
- 2,3-Dichloro-4-iodopyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $30
- Updated
- 2021/12/16
- Product number
- OR303722
- Product name
- 2,3-Dichloro-4-iodopyridine
- Packaging
- 1g
- Price
- $87
- Updated
- 2021/12/16
2,3-Dichloro-4-iodopyridine Chemical Properties,Usage,Production
Synthesis
2402-77-9
889865-45-6
Step 1: Synthesis of 2,3-dichloro-4-iodopyridine Under argon protection, 2,3-dichloropyridine (20 g, 135.1 mmol) was dissolved in anhydrous tetrahydrofuran (350 mL), and cooled to -78 °C. At -78 °C, n-butyllithium (2.4 M hexane solution, 59.12 mL, 141.9 mmol) was slowly added dropwise, and after completion of the dropwise addition, the reaction mixture was continued to be stirred at -78 °C for 90 min. Subsequently, anhydrous tetrahydrofuran (100 mL) solution of iodine (41 g, 161.5 mmol) was slowly added dropwise, and after completion of the dropwise addition, stirring was continued at -78°C for 60 minutes. After completion of the reaction, the reaction mixture was slowly warmed up to room temperature. The reaction was quenched with saturated ammonium chloride solution (100 mL), diluted with water (100 mL) and extracted with ethyl acetate (200 mL x 3). The organic phases were combined, washed with brine solution (200 mL x 2), dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by column chromatography (silica gel, petroleum ether: ethyl acetate= 100:1) to afford the yellow solid product 2,3-dichloro-4-iodopyridine (31.5 g, yield: 85.1%). 1H NMR (300 MHz, DMSO-d6): δ 8.08 (d, J = 5.4 Hz, 1H), 8.65 (d, J = 5.4 Hz, 1H). MS (ESI+): m/z 273.9 [M + H]+.
References
[1] Patent: US2017/29404, 2017, A1. Location in patent: Paragraph 0122-0125
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 6, p. 2688 - 2701
[3] Patent: WO2006/59778, 2006, A1. Location in patent: Page/Page column 57-58
[4] Patent: EP1820797, 2007, A1
[5] Patent: WO2013/5057, 2013, A1. Location in patent: Page/Page column 118
2,3-Dichloro-4-iodopyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,3-Dichloro-4-iodopyridine manufacturers
- Product
- 2,3-Dichloro-4-iodopyridine 889865-45-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98.0%
- Supply Ability
- 1000kg
- Release date
- 2023-04-05
- Product
- 2,3-Dichloro-4-iodopyridine 889865-45-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-01