5-bromo-1-methyl-1H-indole-3-carboxylicacid
- Product Name
- 5-bromo-1-methyl-1H-indole-3-carboxylicacid
- CAS No.
- 400071-95-6
- Chemical Name
- 5-bromo-1-methyl-1H-indole-3-carboxylicacid
- Synonyms
- 5-Bromo-1-methylindole-3-carboxylic acid;5-bromo-1-methyl-1H-indole-3-carboxylicacid;1H-Indole-3-carboxylic acid, 5-bromo-1-methyl-
- CBNumber
- CB02484523
- Molecular Formula
- C10H8BrNO2
- Formula Weight
- 254.08
- MOL File
- 400071-95-6.mol
5-bromo-1-methyl-1H-indole-3-carboxylicacid Property
- Boiling point:
- 441.1±25.0 °C(Predicted)
- Density
- 1.65
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Crystalline Powder
- pka
- 3.80±0.30(Predicted)
- color
- White to off-white
Safety
- HS Code
- 29339980
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- FB144221
- Product name
- 5-Bromo-1-methyl-1H-indole-3-carboxylic acid
- Packaging
- 2g
- Price
- $300
- Updated
- 2021/12/16
- Product number
- AS3795
- Product name
- 5-Bromo-1-methyl-1H-indole-3-carboxylicacid
- Purity
- 97+%
- Packaging
- 5G
- Price
- $426
- Updated
- 2021/12/16
- Product number
- CS-0028257
- Product name
- 5-Bromo-1-methyl-1H-indole-3-carboxylicacid
- Purity
- 99.23%
- Packaging
- 10g
- Price
- $447
- Updated
- 2021/12/16
- Product number
- CS-0028257
- Product name
- 5-Bromo-1-methyl-1H-indole-3-carboxylicacid
- Purity
- 99.23%
- Packaging
- 1g
- Price
- $84
- Updated
- 2021/12/16
- Product number
- FB144221
- Product name
- 5-Bromo-1-methyl-1H-indole-3-carboxylic acid
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
5-bromo-1-methyl-1H-indole-3-carboxylicacid Chemical Properties,Usage,Production
Synthesis
10075-52-2
124-38-9
400071-95-6
In a 50 mL autoclave fitted with a glass inner tube and a magnetic stir bar, 5-bromo-1-methyl-1H-indole (1a, density 1.05 g/mL; 125 μL, 1.00 mmol), dimethylaluminum chloride (1.0 M hexane solution; 1.0 mL, 1.0 mmol), and toluene (1.0 mL) were added, and the mixture was purged with nitrogen under protection by repeated pressurization and subsequent swelling The final pressure was adjusted to 3.0 MPa using a carbon dioxide purge device.The mixture was stirred at 80 °C for 3 h before the reactor was allowed to cool to room temperature and slowly depressurized. The reaction mixture was quenched with 2 M hydrochloric acid solution and the aqueous layer was extracted with ethyl acetate. The combined organic layers were extracted with 0.5 M sodium carbonate solution and the extract was acidified by adding concentrated hydrochloric acid to release the free carboxylic acid and again extracted with ethyl acetate. The extract was dried with anhydrous magnesium sulfate and evaporated under reduced pressure to obtain the residue, which was purified by column chromatography using chloroform-ethyl acetate (1:1, v/v) as eluent to give 1-methyl-5-bromo-3-indolecarboxylic acid (2a) as crystals (168 mg, 96% yield). The carboxylation reaction of other indole derivatives was carried out in a similar way. The crude product was routinely purified by column chromatography using chloroform-ethyl acetate (1:1, v/v) or pure chloroform-ethyl acetate (1:1, v/v) containing 1% (v/v) acetic acid as eluent. The reaction conditions and product yields are shown in Tables 1 and 2.
References
[1] Tetrahedron, 2016, vol. 72, # 5, p. 734 - 745
5-bromo-1-methyl-1H-indole-3-carboxylicacid Preparation Products And Raw materials
Raw materials
Preparation Products
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