4-Fluoro-2(3H)-Benzothiazolethione
- Product Name
- 4-Fluoro-2(3H)-Benzothiazolethione
- CAS No.
- 154327-24-9
- Chemical Name
- 4-Fluoro-2(3H)-Benzothiazolethione
- Synonyms
- 2-mercapto-4-fluorobenzothiazole;4-Fluorobenzo[d]thiazole-2-thiol;4-Fluoro-2-mercaptobenzothiazole;4-Fluoro-2(3H)-Benzothiazolethione;4-Fluoro-1,3-benzothiazole-2-thiol;2(3H)-Benzothiazolethione, 4-fluoro-;4-Fluorobenzo[d]thiazole-2(3H)-thione;4-Fluorobenzo[d]thiazole-2-thiol
- CBNumber
- CB02484604
- Molecular Formula
- C7H4FNS2
- Formula Weight
- 185.24
- MOL File
- 154327-24-9.mol
4-Fluoro-2(3H)-Benzothiazolethione Property
- Melting point:
- 187-188℃
- Boiling point:
- 293.2±42.0 °C(Predicted)
- Density
- 1.55
- storage temp.
- Store at room temperature
- pka
- 8.49±0.20(Predicted)
- form
- solid
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F597003
- Product name
- 4-Fluoro-2-mercaptobenzothiazole
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- HCH0366324
- Product name
- 4-FLUOROBENZO[D]THIAZOLE-2(3H)-THIONE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $257.25
- Updated
- 2021/12/16
- Product number
- PC902198
- Product name
- 4-Fluoro-2-mercaptobenzothiazole
- Purity
- 98%
- Packaging
- 5g
- Price
- $646
- Updated
- 2021/12/16
- Product number
- CD11248323
- Product name
- 4-Fluorobenzo[d]thiazole-2(3H)-thione
- Purity
- 95+%
- Packaging
- 1g
- Price
- $49
- Updated
- 2021/12/16
- Product number
- O1067-00-N
- Product name
- 4-fluorobenzo[d]thiazole-2-thiol
- Purity
- 95%
- Packaging
- 100mg
- Price
- $108
- Updated
- 2021/12/16
4-Fluoro-2(3H)-Benzothiazolethione Chemical Properties,Usage,Production
Synthesis
5509-65-9
140-89-6
154327-24-9
General method: GP3-1: 2,6-Difluoroaniline (1.0 eq.) was dissolved with potassium ethylxanthate (1.2 eq. or 2.2 eq., usually 2.2 eq. was used) in 10 volumes of anhydrous DMF and heated under nitrogen protection for 4 hrs. at 100°C or 120°C. The reaction progress was monitored by TLC. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with 10 volumes of water and neutralized with 1 M HCl solution to pH 5. The resulting precipitate was collected by filtration, washed with water, dried by rotary evaporator and then further dried in an oil pump.GP3-2: Thionyl chloride (SO2Cl2, 1 volume) was slowly added to 10 volumes of anhydrous DMF containing 2-mercaptobenzothiazole (obtained in step GP3-1) under the cooling conditions of an ice bath. step) in 10 volumes of anhydrous DCM solution. The reaction mixture was stirred at room temperature for 1 h. The reaction progress was monitored by TLC. After complete consumption of raw materials, the reaction mixture was diluted with 30 volumes of ether and the reaction was quenched by careful addition of water. Stirring was continued for 1 hour to ensure complete consumption of SO2Cl2 and release of the product. The organic layer was separated, neutralized with saturated NaHCO3 solution, dried over Na2SO4 and finally purified by silica gel column chromatography to afford the pure 2-mercapto-4-fluorobenzothiazole. The structure of the product was confirmed by LC-MS and NMR.
References
[1] Synthetic Communications, 2007, vol. 37, # 3, p. 369 - 376
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 24, p. 7661 - 7670
[3] Advanced Synthesis and Catalysis, 2017, vol. 359, # 11, p. 1837 - 1843
[4] Journal of the American Chemical Society, 2013, vol. 135, # 41, p. 15579 - 15584
4-Fluoro-2(3H)-Benzothiazolethione Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Fluoro-2(3H)-Benzothiazolethione manufacturers
- Product
- 4-Fluorobenzo[d]thiazole-2(3H)-thione 154327-24-9
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.7%
- Supply Ability
- 100 tons
- Release date
- 2022-01-14
- Product
- 4-Fluoro-2(3H)-Benzothiazolethione 154327-24-9
- Price
- US $9.80/KG
- Min. Order
- 1g
- Purity
- ≥99%
- Supply Ability
- 100kg
- Release date
- 2020-01-13