4-Fluoro-2(3H)-Benzothiazolethione

Product Name: 4-Fluoro-2(3H)-Benzothiazolethione
CAS No.: 154327-24-9
Chemical Name: 4-Fluoro-2(3H)-Benzothiazolethione
Synonyms: 2-mercapto-4-fluorobenzothiazole;4-Fluorobenzo[d]thiazole-2-thiol;4-Fluoro-2-mercaptobenzothiazole;4-Fluoro-2(3H)-Benzothiazolethione;4-Fluoro-1,3-benzothiazole-2-thiol;2(3H)-Benzothiazolethione, 4-fluoro-;4-Fluorobenzo[d]thiazole-2(3H)-thione;4-Fluorobenzo[d]thiazole-2-thiol
CBNumber: CB02484604
Molecular Formula: C7H4FNS2
Formula Weight: 185.24
MOL File: 154327-24-9.mol

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4-Fluoro-2(3H)-Benzothiazolethione Property

Melting point:: 187-188℃
Boiling point:: 293.2±42.0 °C(Predicted)
Density: 1.55
storage temp.: Store at room temperature
pka: 8.49±0.20(Predicted)
form: solid
Appearance: White to off-white Solid

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2934208090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F597003
Product name: 4-Fluoro-2-mercaptobenzothiazole
Packaging: 25mg
Price: $45
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0366324
Product name: 4-FLUOROBENZO[D]THIAZOLE-2(3H)-THIONE
Purity: 95.00%
Packaging: 1G
Price: $257.25
Updated: 2021/12/16

Apolloscientific

Product number: PC902198
Product name: 4-Fluoro-2-mercaptobenzothiazole
Purity: 98%
Packaging: 5g
Price: $646
Updated: 2021/12/16

Crysdot

Product number: CD11248323
Product name: 4-Fluorobenzo[d]thiazole-2(3H)-thione
Purity: 95+%
Packaging: 1g
Price: $49
Updated: 2021/12/16

Absolute Chiral

Product number: O1067-00-N
Product name: 4-fluorobenzo[d]thiazole-2-thiol
Purity: 95%
Packaging: 100mg
Price: $108
Updated: 2021/12/16

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4-Fluoro-2(3H)-Benzothiazolethione Chemical Properties,Usage,Production

Synthesis

5509-65-9

140-89-6

154327-24-9

General method: GP3-1: 2,6-Difluoroaniline (1.0 eq.) was dissolved with potassium ethylxanthate (1.2 eq. or 2.2 eq., usually 2.2 eq. was used) in 10 volumes of anhydrous DMF and heated under nitrogen protection for 4 hrs. at 100°C or 120°C. The reaction progress was monitored by TLC. Upon completion of the reaction, the mixture was cooled to room temperature, diluted with 10 volumes of water and neutralized with 1 M HCl solution to pH 5. The resulting precipitate was collected by filtration, washed with water, dried by rotary evaporator and then further dried in an oil pump.GP3-2: Thionyl chloride (SO2Cl2, 1 volume) was slowly added to 10 volumes of anhydrous DMF containing 2-mercaptobenzothiazole (obtained in step GP3-1) under the cooling conditions of an ice bath. step) in 10 volumes of anhydrous DCM solution. The reaction mixture was stirred at room temperature for 1 h. The reaction progress was monitored by TLC. After complete consumption of raw materials, the reaction mixture was diluted with 30 volumes of ether and the reaction was quenched by careful addition of water. Stirring was continued for 1 hour to ensure complete consumption of SO2Cl2 and release of the product. The organic layer was separated, neutralized with saturated NaHCO3 solution, dried over Na2SO4 and finally purified by silica gel column chromatography to afford the pure 2-mercapto-4-fluorobenzothiazole. The structure of the product was confirmed by LC-MS and NMR.

References

[1] Synthetic Communications, 2007, vol. 37, # 3, p. 369 - 376
[2] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 24, p. 7661 - 7670
[3] Advanced Synthesis and Catalysis, 2017, vol. 359, # 11, p. 1837 - 1843
[4] Journal of the American Chemical Society, 2013, vol. 135, # 41, p. 15579 - 15584

4-Fluoro-2(3H)-Benzothiazolethione Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Fluoro-2(3H)-Benzothiazolethione Suppliers

China 48 India 2 United States 7 Global 57

Aladdin Scientific

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View Lastest Price from 4-Fluoro-2(3H)-Benzothiazolethione manufacturers

Honest Joy Holdings Limited

Product: 4-Fluorobenzo[d]thiazole-2(3H)-thione 154327-24-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 97.7%
Supply Ability: 100 tons
Release date: 2022-01-14

Career Henan Chemical Co

Product: 4-Fluoro-2(3H)-Benzothiazolethione 154327-24-9
Price: US $9.80/KG
Min. Order: 1g
Purity: ≥99%
Supply Ability: 100kg
Release date: 2020-01-13

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154327-24-9