5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine
- Product Name
- 5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine
- CAS No.
- 887115-56-2
- Chemical Name
- 5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine
- Synonyms
- 5-Bromo-1-methyl-1H-pyraz...;5-bromo-1-methylpyrazolo[3,4-b]pyridine;5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine;1H-Pyrazolo[3,4-b]pyridine, 5-bromo-1-methyl-
- CBNumber
- CB02485540
- Molecular Formula
- C7H6BrN3
- Formula Weight
- 212.05
- MOL File
- 887115-56-2.mol
5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine Property
- Boiling point:
- 287.0±20.0 °C(Predicted)
- Density
- 1.76±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 1.41±0.30(Predicted)
- form
- crystalline solid
- color
- Light orange
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B405180
- Product name
- 5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 068757
- Product name
- 5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine
- Purity
- >95%
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- 3H32-9-6L
- Product name
- 5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 068757
- Product name
- 5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine
- Purity
- >95%
- Packaging
- 500mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 3H32-9-6L
- Product name
- 5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine
- Purity
- 95%
- Packaging
- 1g
- Price
- $375
- Updated
- 2021/12/16
5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine Chemical Properties,Usage,Production
Synthesis
875781-17-2
74-88-4
887115-56-2
Step 1 Synthesis of 5-bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine (compound 4-2): sodium hydride (720 mg, 30 mmol) and anhydrous tetrahydrofuran (40 mL) were added to a 100 mL reaction flask. After stirring at 0 °C for 5 min, 5-bromo-1H-pyrazolo[3,4-b]pyridine (4.0 g, 20 mmol, commercially available) was dissolved in tetrahydrofuran (20 mL) and slowly added dropwise to the reaction flask through a constant pressure dropping funnel, and stirring was continued for 30 min. Subsequently, iodomethane (1.6 mL, 26 mmol) was added dropwise to the reaction system. After the dropwise addition, the reaction solution was slowly warmed to room temperature and stirred overnight. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction was quenched by the addition of 10 mL of ice water and the tetrahydrofuran was removed by concentration under reduced pressure. The residue was extracted with dichloromethane (60 mL) and water (20 mL x 3). The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 4.1 g of brown solid. The crude product was separated and purified by Combi-flash chromatography [petroleum ether: ethyl acetate = 10:90-40:60] to afford the target compound 5-bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine (4-2) (3.1 g, 73% yield). Mass spectrum (ESI) m/z: 211.9 [M + H]+.
References
[1] Patent: US2017/8889, 2017, A1. Location in patent: Paragraph 0165; 0166
5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine Preparation Products And Raw materials
Raw materials
Preparation Products
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