ChemicalBook > CAS DataBase List > 5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine

5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine

Product Name
5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine
CAS No.
887115-56-2
Chemical Name
5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine
Synonyms
5-Bromo-1-methyl-1H-pyraz...;5-bromo-1-methylpyrazolo[3,4-b]pyridine;5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine;1H-Pyrazolo[3,4-b]pyridine, 5-bromo-1-methyl-
CBNumber
CB02485540
Molecular Formula
C7H6BrN3
Formula Weight
212.05
MOL File
887115-56-2.mol
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5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine Property

Boiling point:
287.0±20.0 °C(Predicted)
Density 
1.76±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
1.41±0.30(Predicted)
form 
crystalline solid
color 
Light orange
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B405180
Product name
5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine
Packaging
100mg
Price
$60
Updated
2021/12/16
Matrix Scientific
Product number
068757
Product name
5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine
Purity
>95%
Packaging
250mg
Price
$85
Updated
2021/12/16
AK Scientific
Product number
2022AF
Product name
5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine
Packaging
10g
Price
$919
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-9-6L
Product name
5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine
Purity
95%
Packaging
5G
Price
$1150
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-9-6L
Product name
5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine
Purity
95%
Packaging
250mg
Price
$125
Updated
2021/12/16
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5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine Chemical Properties,Usage,Production

Synthesis

875781-17-2

74-88-4

887115-56-2

Step 1 Synthesis of 5-bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine (compound 4-2): sodium hydride (720 mg, 30 mmol) and anhydrous tetrahydrofuran (40 mL) were added to a 100 mL reaction flask. After stirring at 0 °C for 5 min, 5-bromo-1H-pyrazolo[3,4-b]pyridine (4.0 g, 20 mmol, commercially available) was dissolved in tetrahydrofuran (20 mL) and slowly added dropwise to the reaction flask through a constant pressure dropping funnel, and stirring was continued for 30 min. Subsequently, iodomethane (1.6 mL, 26 mmol) was added dropwise to the reaction system. After the dropwise addition, the reaction solution was slowly warmed to room temperature and stirred overnight. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, the reaction was quenched by the addition of 10 mL of ice water and the tetrahydrofuran was removed by concentration under reduced pressure. The residue was extracted with dichloromethane (60 mL) and water (20 mL x 3). The organic layer was dried with anhydrous sodium sulfate and concentrated under reduced pressure to give 4.1 g of brown solid. The crude product was separated and purified by Combi-flash chromatography [petroleum ether: ethyl acetate = 10:90-40:60] to afford the target compound 5-bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine (4-2) (3.1 g, 73% yield). Mass spectrum (ESI) m/z: 211.9 [M + H]+.

References

[1] Patent: US2017/8889, 2017, A1. Location in patent: Paragraph 0165; 0166

5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridine Suppliers

China 55 India 1 United States 6 Global 62
Alchem Pharmtech,Inc.
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8485655694
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sales@alchempharmtech.com
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United States
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Aladdin Scientific
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tp@aladdinsci.com
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United States
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52923
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Synthonix Inc
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Combi-Blocks Inc.
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sales@combi-blocks.com
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United States
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6618
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SynQuest Laboratories, Inc.
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Country
United States
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6871
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Matrix Scientific
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Email
sales@matrixscientific.com
Country
United States
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6632
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887115-56-2, 5-Bromo-1-methyl-1H-pyrazolo[3,4-b]pyridineRelated Search:


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