Methyl 1-Cbz-azetidine-3-carboxylate

Product Name: Methyl 1-Cbz-azetidine-3-carboxylate
CAS No.: 757239-60-4
Chemical Name: Methyl 1-Cbz-azetidine-3-carboxylate
Synonyms: Methyl 1-Cbz-azetidine-3-...;Methyl 1-Cbz-azetidine-3-carboxylate;1-Cbz-3-azetidinecarboxylic acid Methyl ester;1-benzyl 3-Methyl azetidine-1,3-dicarboxylate;1-CBZ-AZETIDINE-3-CARBOXYLIC ACID METHYL ESTER;O1-benzyl O3-methyl azetidine-1,3-dicarboxylate;Methyl 1-benzyloxycarbonylazetidine-3-carboxylate;1-benzyloxycarbonyl-3-azetidinecarboxylic acid methyl ester;1-Benzyloxycarbonyl-3-azetidinecarboxylic acid methyl ester 97%;azetidine-1,3-dicarboxylic acid O3-methyl ester O1-(phenylmethyl) ester
CBNumber: CB02485595
Molecular Formula: C13H15NO4
Formula Weight: 249.26
MOL File: 757239-60-4.mol

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Methyl 1-Cbz-azetidine-3-carboxylate Property

Boiling point:: 359.3±42.0 °C(Predicted)
Density: 1.259±0.06 g/cm3(Predicted)
storage temp.: 2-8°C
pka: -3.02±0.40(Predicted)
form: solid
color: White
CAS DataBase Reference: 757239-60-4

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B535298
Product name: 1-Benzyl3-MethylAzetidine-1,3-dicarboxylate
Packaging: 10mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B535298
Product name: 1-Benzyl3-MethylAzetidine-1,3-dicarboxylate
Packaging: 50mg
Price: $60
Updated: 2021/12/16

Synthonix

Product number: M7525
Product name: Methyl1-Cbz-azetidine-3-carboxylate
Purity: 97.0%
Packaging: 5g
Price: $50
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H58-1-A7
Product name: Methyl 1-Cbz-azetidine-3-carboxylate
Purity: 97.0%
Packaging: 5G
Price: $100
Updated: 2021/12/16

Matrix Scientific

Product number: 112234
Product name: Methyl 1-Cbz-azetidine-3-carboxylate
Packaging: 1g
Price: $246
Updated: 2021/12/16

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Methyl 1-Cbz-azetidine-3-carboxylate Chemical Properties,Usage,Production

Uses

Methyl 1-Cbz-azetidine-3-carboxylate is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl 1-Cbz-azetidine-3-carboxylate is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1

IC 50

Non-cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. DOI:10.1038/nrd.2016.268
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

Methyl 1-Cbz-azetidine-3-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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Methyl 1-Cbz-azetidine-3-carboxylate Suppliers

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757239-60-4, Methyl 1-Cbz-azetidine-3-carboxylateRelated Search:

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1-benzyl 3-Methyl azetidine-1,3-dicarboxylate

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azetidine-1,3-dicarboxylic acid O3-methyl ester O1-(phenylmethyl) ester

757239-60-4