spiro[isochroman-1,4'-piperidine]

Product Name: spiro[isochroman-1,4'-piperidine]
CAS No.: 180160-97-8
Chemical Name: spiro[isochroman-1,4'-piperidine]
Synonyms: spiro[isochroman-1,4'-piperidine];spiro[isochromane-1,4'-piperidine;Spiro[isochroman-1,4'-piperidine]?New;3,4-Dihydrospiro[isochromene-1,4'-piperidine];3,4-dihydrospiro[2-benzopyran-1,4'-piperidine];Spiro[1H-2-benzopyran-1,4'-piperidine], 3,4-dihydro-
CBNumber: CB02489816
Molecular Formula: C13H17NO
Formula Weight: 203.28
MOL File: 180160-97-8.mol

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spiro[isochroman-1,4'-piperidine] Property

Boiling point:: 341.3±42.0 °C(Predicted)
Density: 1.12
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
pka: 10.21±0.20(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: S683533
Product name: Spiro[isochroman-1,4''-piperidine]
Packaging: 25mg
Price: $45
Updated: 2021/12/16

Matrix Scientific

Product number: 119220
Product name: Spiro[isochroman-1,4'-piperidine]
Purity: 95+%
Packaging: 250mg
Price: $231
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0097289
Product name: SPIRO[ISOCHROMAN-1,4'-PIPERIDINE]
Purity: 95.00%
Packaging: 5MG
Price: $503.71
Updated: 2021/12/16

Matrix Scientific

Product number: 119220
Product name: Spiro[isochroman-1,4'-piperidine]
Purity: 95+%
Packaging: 1g
Price: $576
Updated: 2021/12/16

AK Scientific

Product number: W3911
Product name: Spiro[isochroman-1,4'-piperidine]
Packaging: 5g
Price: $748
Updated: 2021/12/16

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spiro[isochroman-1,4'-piperidine] Chemical Properties,Usage,Production

Synthesis

909034-76-0

180160-97-8

The general procedure for the synthesis of spiro[isobenzodihydropyran-1,4'-piperidine]-1'-carboxylic acid tert-butyl ester from spiro[isobenzodihydropyran-1,4'-piperidine] is as follows: Step 1: Deprotection reaction Trifluoroacetic acid (15 mL) was added to a solution of tert-butyl spiro[isobenzodihydropyran-1,4'-piperidine]-1'-carboxylate (3.3 g, 10.87 mmol) in dichloromethane (15 mL), and the reaction was stirred for 2 h at room temperature. Step 2: Post-treatment The reaction mixture was concentrated under reduced pressure and the residue was redissolved in dichloromethane (15 mL). Alkalization was carried out by adjusting the pH to 8 with aqueous sodium carbonate. The organic and aqueous phases were separated and the organic phase was washed sequentially with water, sodium bicarbonate solution and saturated saline. The organic phase was dried over anhydrous sodium sulfate and the solvent was evaporated under reduced pressure. Step 3: Purification The obtained residue was ground with ether to obtain white solid spiro[isobenzodihydropyran-1,4'-piperidine] (1.35 g, 64% yield). Characterization data: 1H NMR (DMSO-d6, 400 MHz) δ: 1.88 (m, 2H), 2.09 (m, 2H), 2.77 (t, 2H), 3.02 (m, 2H), 3.15 (m, 2H), 3.90 (t, 2H), 7.10-7.28 (m, 4H). LRMS: m/z APCI+ 204 [MH]+.

References

[1] Patent: WO2006/92731, 2006, A1. Location in patent: Page/Page column 42

spiro[isochroman-1,4'-piperidine] Preparation Products And Raw materials

Raw materials

Preparation Products

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spiro[isochroman-1,4'-piperidine] Suppliers

China 39 India 1 Switzerland 1 United States 5 Global 46

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180160-97-8, spiro[isochroman-1,4'-piperidine]Related Search:

spiro[isochroman-1,4'-piperidine]

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3,4-Dihydrospiro[isochromene-1,4'-piperidine]

Spiro[isochroman-1,4'-piperidine]?New

spiro[isochromane-1,4'-piperidine

180160-97-8