ChemicalBook > CAS DataBase List > BIX 02188

BIX 02188

Product Name
BIX 02188
CAS No.
1094614-84-2
Chemical Name
BIX 02188
Synonyms
CS-38;BIX 02188;(E/Z)-BIX02188;BIX 02188, >=98%;BIX 02188 USP/EP/BP;BIX 02188(BIX-02188;BIX 02188(BIX-02188;BIX02188);BIX-02188(Random Configuration);BIX-02188 BIX02188MEK5 inhibitor potent and selective;3-(((3-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxamide
CBNumber
CB02489917
Molecular Formula
C25H24N4O2
Formula Weight
412.48366
MOL File
1094614-84-2.mol
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BIX 02188 Property

Melting point:
>268oC (dec.)
Boiling point:
615.8±55.0 °C(Predicted)
Density 
1.283
storage temp. 
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
11.19±0.20(Predicted)
color 
Yellow
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B591685
Product name
BIX02188
Packaging
10mg
Price
$150
Updated
2021/12/16
Usbiological
Product number
162918
Product name
BIX02188
Packaging
10mg
Price
$460
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
KIN0000917
Product name
3-[[[3-[(DIMETHYLAMINO)METHYL]PHENYL]AMINO]PHENYLMETHYLENE]-2,3-DIHYDRO-2-OXO-1H-INDOLE-6-CARBOXAMIDE
Purity
95.00%
Packaging
5MG
Price
$496.31
Updated
2021/12/16
Biorbyt Ltd
Product number
orb154720
Product name
BIX02188 (BIX 02188)
Purity
>98%
Packaging
100mg
Price
$765
Updated
2021/12/16
AK Scientific
Product number
X7394
Product name
(Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxamide
Packaging
50mg
Price
$876
Updated
2021/12/16
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BIX 02188 Chemical Properties,Usage,Production

Uses

BIX02188 MEK inhibitor, prevents cell proliferation and induces apoptosis. Can be applied towards treatments of cancers and proliferative cell diseases.

Biological Activity

bix 02188 is a selective inhibitor of mek5 with ic50 value of 4.3 nm 1.bix 02188 belongs to the indolinone kinase inhibitor series. it selectively inhibited the catalytic activity of mek5 but not other closely related kinases such as mek1, mek2, erk2 and jnk2. bix 02188 also inhibited erk5 with ic50 value of 810 nm. in hela cells, treatment of bix 02188 inhibited the phosphorylation of erk5 but not erk1/2. besides that, bix 02188 prevented the transcription of the downstream substrate mef2c in hela and hek293 cells. when tested with a panel of 79 kinases, bix 02188 showed some degree of inhibition of the kinases csf1r, kit and lck with ic50 values of 280 nm, 550 nm and 390 nm, respectively 1.

target

MEK5

References

1. tatake r j, o’neill m m, kennedy c a, et al. identification of pharmacological inhibitors of the mek5/erk5 pathway. biochemical and biophysical research communications, 2008, 377(1): 120-125.

BIX 02188 Preparation Products And Raw materials

Raw materials

Preparation Products

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BIX 02188 Suppliers

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1094614-84-2, BIX 02188Related Search:

Selumetinib MK-2206 2HCl Enzalutamide BIX 02189 Carfilzomib Olaparib

  • 3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide
  • BIX 02188
  • BIX 02188(BIX-02188
  • BIX 02188(BIX-02188;BIX02188)
  • BIX-02188(Random Configuration)
  • (Z)-3-((3-((dimethylamino)methyl)phenylamino)(phenyl)methylene)-2-oxoindoline-6-carboxamide
  • 3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-1H-indole-6-carboxamide BIX 02188
  • BIX 02188, >=98%
  • CS-38
  • 3-(((3-((Dimethylamino)methyl)phenyl)amino)(phenyl)methylene)-2-oxoindoline-6-carboxamide
  • BIX 02188 USP/EP/BP
  • (E/Z)-BIX02188
  • BIX-02188 BIX02188MEK5 inhibitor potent and selective
  • 1H-Indole-6-carboxamide, 3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-2-oxo-
  • 1094614-84-2
  • Inhibitors
  • MAPK