1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine

Product Name: 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine
CAS No.: 180300-43-0
Chemical Name: 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine
Synonyms: ECyd;TAS 106;ETHYNYCYTIDINE;Ethynylcytidine;3'-ethynylcytidine;3'-C-Ethynylcytidine;Ethynylcytidine(ECyD);3’-β-C-Ethynylcytidine;cytidine, 3'-c-ethynyl-;3'-beta-C-Ethynylcytidine
CBNumber: CB02490124
Molecular Formula: C11H13N3O5
Formula Weight: 267.24
MOL File: 180300-43-0.mol

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1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine Property

Melting point:: 233-235 °C
Boiling point:: 536.4±60.0 °C(Predicted)
Density: 1.61±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:127.5(Max Conc. mg/mL);477.1(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);18.71(Max Conc. mM)
PBS (pH 7.2):10.0(Max Conc. mg/mL);37.42(Max Conc. mM)
form: A solid
pka: 11.54±0.70(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 27681
Product name: Ethynylcytidine
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 27681
Product name: Ethynylcytidine
Packaging: 10mg
Price: $257
Updated: 2024/03/01

Cayman Chemical

Product number: 27681
Product name: Ethynylcytidine
Packaging: 5mg
Price: $151
Updated: 2024/03/01

TRC

Product number: E932630
Product name: Ethynylcytidine
Packaging: 10mg
Price: $220
Updated: 2021/12/16

ChemScene

Product number: CS-0006185
Product name: Ethynylcytidine
Purity: 99.52%
Packaging: 5mg
Price: $140
Updated: 2021/12/16

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1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine Chemical Properties,Usage,Production

Uses

Ethynylcytidine, is a new nucleoside antimetabolite, and an RNA polymerase inhibitor, combined with cisplatin exhibits a potent synergistic growth-inhibitory effect via Vaults dysfunction

in vivo

In both OCUM-2MD3 and LX-1 xenografts, tumor regression is noted and a very potent antitumor effect with an tumor growth inhibition rate (IR) on day 15 of approximately 90% or even higher is observed at the minimum toxic doses of Ethynylcytidine (TAS-106) on all three administration schedules. In particular, administration of Ethynylcytidine at 6 mg/kg once weekly exhibits a marked tumor shrinking effect with an IR of 98% against the LX-1 tumor. While Ethynylcytidine treatment on an either 3 or 5 times weekly schedule has a potent antitumor effect with an IR of approximately 85%, the IR of Ethynylcytidine once weekly is less than 60% and its antitumor effect is rather weak^[1].

1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine Suppliers

China 44 India 1 United States 5 Global 50

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180300-43-0, 1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosineRelated Search:

1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine

ETHYNYCYTIDINE

ECyd

TAS 106

Ethynylcytidine

4-Amino-1-((2R,3R,4S,5R)-4-ethynyl-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one

cytidine, 3'-c-ethynyl-

1-(3-C-ETHYNYL-BETA-D-RIBO-PENTOFURANOSYL)CYTOSINE

Ethynylcytidine (TAS-106)

3'-beta-C-Ethynylcytidine

3'-C-Ethynylcytidine

ECYD;TAS-106;3'-C-ETHYNYLCYTIDINE

3’-beta-C-Ethynylcytidine, ECYD, TAS-106

3’-β-C-Ethynylcytidine

Ethynylcytidine(ECyD)

4-Amino-1-[(2R,3R,4S,5R)-4-ethynyl-3,4-dihydroxy-5-(hydroxymethyl)-2-tetrahydrofuryl]pyrimidin-2(1H)-one

3’-beta-C-Ethynylcytidine

3'-ethynylcytidine

1-(3-C-ethynyl-β-D-ribo-pentofuranosyl)cytosine

180300-43-0

Nucleosides