Description References
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Unii-o0p4I5851i

Description References
Product Name
Unii-o0p4I5851i
CAS No.
139563-29-4
Chemical Name
Unii-o0p4I5851i
Synonyms
Unii-o0p4I5851i;Lurasidone Impurity E;Lurasidone hydrochloride
CBNumber
CB02493594
Molecular Formula
C28H37ClN4O2S
Formula Weight
529.13698
MOL File
139563-29-4.mol
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Unii-o0p4I5851i Property

Melting point:
>250°C (dec.)
storage temp. 
Refrigerator
solubility 
Chloroform (Very Slightly, Sonicated), Methanol (Slightly, Heated)
form 
Solid
color 
White to Off-White
CAS DataBase Reference
139563-29-4
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Hazard and Precautionary Statements (GHS)

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Unii-o0p4I5851i Chemical Properties,Usage,Production

Description

Lurasidone hydrochloride is the hydrochloride form of Lurasidone. It is an atypical antipsychotic. It is indicated for the treatment of schizophrenia, depressive episode associated with bipolar I disorder in adults when used alone or in combination with lithium or valproate. Lurasidone is a benzothiazol derivative that is an antagonist and binds with high affinity to Dopamine-2, 5-HT2A receptor, and 5-H7 receptors. It is generally thought that antagonism of serotonin receptors can improve the negative symptoms of psychoses and reduce the extrapyramidal side effects associated with typical antipsychotics.  

References

Nakamura, M, et al. "Lurasidone in the treatment of acute schizophrenia: a double-blind, placebo-controlled trial." Journal of Clinical Psychiatry70.6(2009):829.
Meyer, J. M., A. D. Loebel, and E. Schweizer. "Lurasidone: a new drug in development for schizophrenia." Expert Opinion on Investigational Drugs18.11(2009):1715.
https://en.wikipedia.org/wiki/Lurasidone
https://www.drugbank.ca/drugs/DB08815

Uses

An antipsychotic used for treatment of schizophrenia.

Clinical Use

Lurasidone hydrochloride is an antipsychotic developed by the Japanese firm Dainippon Sumitomo and approved by the U.S. FDA for the treatment of schizophrenia. The compound exhibits significant antagonist effects at the D2, 5-HT2A, and 5-HT7 receptors which are linked to learning and cognition. In contrast to available antipsychotics, lurasidone lacks anticholinergic side effects, giving it an improved safety profile against existing treatments.139 The drug is manufactured under the trade name Latuda and possesses a linear molecular topology which can be subdivided into three regions: a piperazine benzothiazole, a [2.2.1]-bicycloheptane fused succinimide, and a trans-1,2 disubstituted cyclohexane.

Synthesis

The large scale preparation of lurasidone involves an interesting ring-opening alkylation reaction of a spirocyclic tetralkyl ammonium salt to produce the 1,2-trans-substituted cyclohexane subunit. The synthesis commenced with the bismesylation of commercially available diol 177, which proceeded in high yield to give disulfone 178. This bis-electrophile underwent dialkylation with commercially available piperazine 179 under basic conditions, giving rise to ammonium species 180, isolated in 80% yield as the mono-mesylate salt. This compound was immediately subjected to alkylative conditions in the presence of commercially available succinimide 181 to provide lurasidone in 94% yield from 180, and lurasidone hydrochloride (XVI) was achieved by subsequent salt formation procedure.

Unii-o0p4I5851i Preparation Products And Raw materials

Raw materials

Preparation Products

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Unii-o0p4I5851i Suppliers

TEVA PHARMACEUTICAL INDUSTRIES LTD
Tel
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Fax
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Email
megan.carroll@tevapharm.com
Country
Israel
ProdList
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139563-29-4, Unii-o0p4I5851iRelated Search:


  • Lurasidone hydrochloride
  • Unii-o0p4I5851i
  • Lurasidone Impurity E
  • 139563-29-4