2-Methoxy-3-nitro-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridine

Product Name: 2-Methoxy-3-nitro-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridine
CAS No.: 1083168-94-8
Chemical Name: 2-Methoxy-3-nitro-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridine
Synonyms: 2-Methoxy-3-nitropyridine-5-boronic acid pinacol ester;2-Methoxy-3-nitropyridine-5-boronicacidpinacolester,96%;2-Methoxy-3-nitropyridin-5-ylboronic acid pinacol ester;2-Methoxy-3-nitropyridine-5-boronic acid pinacol ester, 96%;2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-nitropyridine;Pyridine, 2-methoxy-3-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-;2-Methoxy-3-nitro-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridine
CBNumber: CB02499268
Molecular Formula: C12H17BN2O5
Formula Weight: 280.08
MOL File: 1083168-94-8.mol

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2-Methoxy-3-nitro-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridine Property

Melting point:: 118-119°
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: Light yellow to yellow Solid
CAS DataBase Reference: 1083168-94-8

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: M266008
Product name: 2-Methoxy-3-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Packaging: 500mg
Price: $285
Updated: 2021/12/16

AK Scientific

Product number: Z7216
Product name: 2-Methoxy-3-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine
Packaging: 5g
Price: $923
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: BOR0006447
Product name: 2-METHOXY-3-NITRO-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
Purity: 95.00%
Packaging: 1G
Price: $508.2
Updated: 2021/12/16

AK Scientific

Product number: Z7216
Product name: 2-Methoxy-3-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-pyridine
Packaging: 1g
Price: $269
Updated: 2021/12/16

Ambeed

Product number: A138986
Product name: 2-Methoxy-3-nitro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Purity: 95+%
Packaging: 1g
Price: $93
Updated: 2021/12/16

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2-Methoxy-3-nitro-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridine Chemical Properties,Usage,Production

Synthesis

152684-30-5

73183-34-3

1083168-94-8

The reaction was carried out with 5-bromo-2-methoxy-3-nitropyridine (5 g, 21.5 mmol) and pinacol ester of bis(boronic acid) (6.6 g, 25.8 mmol) in the presence of PdCl2(dppf)-CH2Cl2 (500 mg) and potassium acetate (6.3 g, 64.5 mmol) in anhydrous 1,4-dioxane (200 mL) at reflux for 2 hour. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by silica gel column chromatography with the eluent of petroleum ether:EtOAc = 10:1 to afford the target compound 2-methoxy-3-nitro-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridine in 81% (5 g) yield. Mass spectral analysis showed m/z 281 (M + H)+.

References

[1] Patent: WO2012/34526, 2012, A1. Location in patent: Page/Page column 33
[2] Patent: US2013/190307, 2013, A1. Location in patent: Paragraph 0158; 0159
[3] Patent: WO2008/141119, 2008, A2. Location in patent: Page/Page column 105
[4] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 3, p. 256 - 261

2-Methoxy-3-nitro-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Methoxy-3-nitro-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridine Suppliers

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1083168-94-8, 2-Methoxy-3-nitro-5-(4,4,5,5-tetramethyl-[1,3,2] dioxaborolan-2-yl)-pyridineRelated Search:

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1083168-94-8