ChemicalBook > CAS DataBase List > Methyl 2-(Boc-amino)isonicotinate
Methyl 2-(Boc-amino)isonicotinate
Application- Product Name
- Methyl 2-(Boc-amino)isonicotinate
- CAS No.
- 639091-75-1
- Chemical Name
- Methyl 2-(Boc-amino)isonicotinate
- Synonyms
- Methyl 2-(Boc-amino)isonicotinate;2-Boc-amino-isonicotinic acid methyl ester;Methyl 2-((tert-butoxycarbonyl)aMino)isonicotinate;2-tert-Butoxycarbonylamino-isonicotinic acid methyl ester;methyl 2-(tert-butoxycarbonylamino)pyridine-4-carboxylate;Methyl 2-[(2-methylpropan-2-yl)oxycarbonylamino]pyridine-4-carboxylate;2-[[(1,1-Dimethylethoxy)carbonyl]amino]-4-pyridinecarboxylic acidmethylester;4-Pyridinecarboxylic acid, 2-[[(1,1-diMethylethoxy)carbonyl]aMino]-, Methyl ester
- CBNumber
- CB02499400
- Molecular Formula
- C12H16N2O4
- Formula Weight
- 252.27
- MOL File
- 639091-75-1.mol
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Methyl 2-(Boc-amino)isonicotinate Property
- Melting point:
- 75.1～75.2℃
- Boiling point:
- 325.5±27.0 °C(Predicted)
- Density
- 1.203±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 12.12±0.70(Predicted)
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Safety
- HS Code
- 2922390090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
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N-Bromosuccinimide Price
TRC
- Product number
- M295635
- Product name
- Methyl2-(Boc-amino)isonicotinate
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 018214
- Product name
- 2-(2,2-Dimethyl-propionylamino)-isonicotinic acidmethyl ester
- Packaging
- 500mg
- Price
- $116
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 118101
- Product name
- Methyl 2-((tert-butoxycarbonyl)amino)isonicotinate
- Packaging
- 5g
- Price
- $301
- Updated
- 2021/12/16
SynQuest Laboratories
- Product number
- 4H58-1-8C
- Product name
- Methyl 2-((tert-butoxycarbonyl)amino)isonicotinate
- Packaging
- 5G
- Price
- $356
- Updated
- 2021/12/16
AK Scientific
- Product number
- Y6341
- Product name
- Methyl2-(tert-butoxycarbonylamino)isonicotinate
- Packaging
- 10g
- Price
- $370
- Updated
- 2021/12/16
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Methyl 2-(Boc-amino)isonicotinate Chemical Properties,Usage,Production
Application
2-(BOC-amino)isonicotinic acid methyl ester, also known as Boc-isonicotinic acid methyl ester, is an organic compound widely used in the synthesis of various compounds. It is an important intermediate in the synthesis of pharmaceuticals, agrochemicals, and other chemicals. Furthermore, 2-(BOC-amino)isonicotinic acid methyl ester is used in the synthesis of many other compounds, including amides, nitriles, and amines. It is also used in the synthesis of peptides, peptide analogs, and other peptide mimics.
Synthesis
A 500 mL round bottomed flask was charged with methyl 2-aminoisonicotinate (5.0 g, 32.9 mmol) and suspended in t-BuOH (200 mL). To this stirring solution was added di-tert-butyl dicarbonate (7.53 g, 34.5 mmol). The flask was vented and placed in an oil bath preheated to 50°C. The reaction mixture was let stir overnight. After 22 hours LCMS showed near complete conversion of starting material. The mixture was cooled to room temperature and filtered. The material was taken on without any further purification. Yield 5.93 g of white solid, Methyl 2-(Boc-amino)isonicotinate. 1H NMR (400 MHz, DMSO-d6) δ ppm 10.14 (1H, s), 8.43 (1H, dd, J=5.02, 0.75 Hz), 8.33 (1H, s), 7.45 (1H, dd, J=5.02, 1.51 Hz), 3.89 (3H, s), 1.48 (9H, s).
Methyl 2-(Boc-amino)isonicotinate Preparation Products And Raw materials
Raw materials
Preparation Products
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