Ethyl4-benzylmorpholine-2-carboxylate
- Product Name
- Ethyl4-benzylmorpholine-2-carboxylate
- CAS No.
- 135072-32-1
- Chemical Name
- Ethyl4-benzylmorpholine-2-carboxylate
- Synonyms
- Ethyl4-benzylmorpholine-2-carboxylate;Ethyl 4-Benzyl-2-morpholinecarboxylate;4-Phenylmethyl-2-morpholinecarboxylic acid ethyl ester;2-Morpholinecarboxylic acid, 4-(phenylmethyl)-, ethyl ester
- CBNumber
- CB02500494
- Molecular Formula
- C14H19NO3
- Formula Weight
- 249.31
- MOL File
- 135072-32-1.mol
Ethyl4-benzylmorpholine-2-carboxylate Property
- Boiling point:
- 330.3±37.0 °C(Predicted)
- Density
- 1.128
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 5.70±0.10(Predicted)
- Appearance
- Colorless to light yellow Liquid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P318880
- Product name
- 4-Phenylmethyl-2-morpholinecarboxylicAcidEthylEster
- Packaging
- 1g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- X9900
- Product name
- Ethyl4-benzylmorpholine-2-carboxylate
- Packaging
- 1g
- Price
- $118
- Updated
- 2021/12/16
- Product number
- X9900
- Product name
- Ethyl4-benzylmorpholine-2-carboxylate
- Packaging
- 5g
- Price
- $293
- Updated
- 2021/12/16
- Product number
- 175566
- Product name
- Ethyl 4-benzyl-2-morpholinecarboxylate
- Packaging
- 1g
- Price
- $316
- Updated
- 2021/12/16
- Product number
- CHM0077686
- Product name
- 4-(PHENYLMETHYL)-2-MORPHOLINECARBOXYLIC ACID ETHYL ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $703.4
- Updated
- 2021/12/16
Ethyl4-benzylmorpholine-2-carboxylate Chemical Properties,Usage,Production
Uses
4-Phenylmethyl-2-morpholinecarboxylic Acid Ethyl Ester is an intermediate used to prepare 5-HT4 receptor agonists and gastric motility stimulants.
Synthesis
64-17-5
147767-51-9
135072-32-1
1. 4-Benzylmorpholine-2-carbonitrile (113.0 g, 0.56 mol) was dissolved in ethanol (1030 mL) and stirred to form a homogeneous solution. 2. Concentrated sulfuric acid (165 mL) was added slowly and in batches with stirring, taking care to control the rate of addition in order to manage the exothermic reaction (the internal temperature was raised from room temperature to 65°C during the reaction). 3. After completion of the addition, the reaction mixture was heated to a reflux condition and maintained for 66 hours. 4. reflux, and the reaction was maintained for 66 h. 4. Upon completion of the reaction, the solution was cooled to room temperature and subsequently concentrated to half the original volume under reduced pressure. 5. The concentrate was carefully alkalinized with aqueous potassium carbonate (taking care to prevent foaming due to carbon dioxide release), and subsequently separated by extraction with ether. 6. The organic phases were combined, dried with anhydrous magnesium sulfate, and filtered to remove the drying agent. 7. The filtrate was evaporated under reduced pressure to remove the solvent. The filtrate was evaporated under reduced pressure to remove the solvent to give an oily crude product.8. The crude product was further dried under high vacuum to remove residual volatiles. The final product was 121.3 g of ethyl N-benzylmorpholine-2-carboxylate in 87% yield.
References
[1] Patent: WO2005/47272, 2005, A1. Location in patent: Page/Page column 49-50
[2] Patent: WO2005/47272, 2005, A1. Location in patent: Page/Page column 50
[3] Patent: WO2005/60949, 2005, A2. Location in patent: Page/Page column 276
[4] Journal of Medicinal Chemistry, 1993, vol. 36, # 6, p. 683 - 689
[5] Tetrahedron Letters, 1991, vol. 32, # 20, p. 2281 - 2284
Ethyl4-benzylmorpholine-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Ethyl4-benzylmorpholine-2-carboxylate manufacturers
- Product
- Ethyl4-benzylmorpholine-2-carboxylate 135072-32-1
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 500g； 1kg; 25kg
- Release date
- 2020-01-10
- Product
- Ethyl4-benzylmorpholine-2-carboxylate 135072-32-1
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2019-12-25