ChemicalBook > CAS DataBase List > (7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol

(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol

Product Name
(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol
CAS No.
875573-67-4
Chemical Name
(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol
Synonyms
Fulvestrant int3;Fulvestrant Impurity 43;Fulvestrant intermediate N-2;Fulvestrant interMediate N-2(1);Fulvestrant Intermediates--5-1(N-3-1);Fulvestrant intermediate N-3 hydrolysate;7α-(9-Bromononyl)estra-1,3,5(10)-triene-3,17β-diol;(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol;(7α,17β)-7-(9-bromononyl)estra-1,3,5(10)-triene-3,17-diol;"(7α,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol"
CBNumber
CB02500681
Molecular Formula
C27H41BrO2
Formula Weight
477.53
MOL File
875573-67-4.mol
More
Less

(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol Property

Boiling point:
586.1±50.0 °C(Predicted)
Density 
1.196
storage temp. 
Sealed in dry,Room Temperature
pka
10.27±0.70(Predicted)
InChIKey
ILWDBZWOZQESSY-RIVKPNGLNA-N
SMILES
C([C@@H]1CC2=CC(O)=CC=C2[C@@]2([H])CC[C@@]3([C@@H](O)CC[C@@]3([H])[C@]12[H])C)CCCCCCCCBr |&1:1,10,14,15,19,21,r|
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H360May damage fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

TRC
Product number
B687533
Product name
(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol
Packaging
50mg
Price
$65
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB152400
Product name
(7a,17beta)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol
Packaging
250ug
Price
$67.5
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB152400
Product name
(7a,17beta)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol
Packaging
500ug
Price
$115
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB152400
Product name
(7a,17beta)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol
Packaging
2mg
Price
$352
Updated
2021/12/16
Matrix Scientific
Product number
095273
Product name
(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol
Purity
95+%
Packaging
1g
Price
$385
Updated
2021/12/16
More
Less

(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol Chemical Properties,Usage,Production

Uses

(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol is used in the synthetic preparation of 7α-alkylated 19-norsteroids.

Definition

(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol is a Fulvestrant intermediate.

Synthesis

875573-66-3

875573-67-4

Synthesis of (7R,8R,9S,13S,14S,17S)-7-(9-bromononyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a ]phenanthrene-3,17-diol was performed in the following general steps: the compound of Formula II (5.0 g) prepared in Example 1 was added to a reaction flask with methanol (50 mL) and heated until dissolved. Subsequently, aqueous hydrobromic acid (5 mL of 40 mL) was slowly added and the reaction was carried out at 60 °C for 2 hours. After completion of the reaction, it was cooled to room temperature and the solid product was collected by filtration. The resulting solid was dried in a vacuum oven at 40 °C for 8 h to afford the compound of formula III (4.3 g), which was tested to be 97.7% pure.

References

[1] Patent: US2006/30552, 2006, A1. Location in patent: Page/Page column 25
[2] Patent: CN107325143, 2017, A. Location in patent: Paragraph 0010; 0011; 0012

(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol Suppliers

China 136 India 2 United Kingdom 1 United States 4 Global 143
Hangzhou nuotong biotechnology co. LTD
Tel
0571-86297909 15268405618
Email
sisi.xiang@sinopep.com
Country
China
ProdList
86
Advantage
58
Hunan Eurasian Pharmaceutical Co. Ltd.
Tel
0592-5789919 13328776692
Email
2851802016@qq.com
Country
China
ProdList
79
Advantage
58
Tianjin Nuohan Chemical Co., Ltd.
Tel
166-22132757 13802164402
Fax
QQ：1732062680
Email
zhuxuchen2016@yeah.net
Country
China
ProdList
99
Advantage
58
Beijing HwrkChemical Technology Co., Ltd
Tel
18515581800 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
9400
Advantage
55
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
DONGSHENG CHIRAL PHARMA
Tel
15800326364 18051538752
Email
582512789@qq.com
Country
China
ProdList
449
Advantage
55
Beijing Universal Century Technology Co., Ltd.
Tel
400-8706899
Fax
400-8706899
Email
hysj_bj.com
Country
China
ProdList
3583
Advantage
55
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10263
Advantage
55
Shanghai Kewel Chemical Co., Ltd.
Tel
021-64609169 18901607656
Fax
021-64609160
Email
greensnown@163.com
Country
China
ProdList
9906
Advantage
50
Credit Asia Chemical Co., Ltd.
Tel
+86 (21) 61124340
Fax
+86 (21) 6129-4103
Country
China
ProdList
9756
Advantage
58
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9484
Advantage
50
Hangzhou Lenny Technology Co. , Ltd.
Tel
571-88086013
Fax
0571- 88088387
Email
sunnie@rdpharm.com
Country
China
ProdList
105
Advantage
60
Xiamen Halosyntech Co., Ltd
Tel
0592-6688068 18106901346
Fax
0592-6686768
Email
qbl2015@halolife.cn
Country
China
ProdList
127
Advantage
55
Jinan Putubio Tech Co., Ltd.
Tel
+86 (531) 8099-2215
Fax
+86 (531) 8099-2215
Email
putubio@outlook.com
Country
China
ProdList
1261
Advantage
55
Shanghai Haozhixiang Biotechnology Co., Ltd
Tel
526763801 13301653310
Fax
+86-21-51619052
Email
526763801@qq.com
Country
China
ProdList
9274
Advantage
55
parabiochem
Tel
025-83453382-8005
Fax
025-83453382
Email
sale@parabiochem.com
Country
China
ProdList
9595
Advantage
55
Nanjing Ally Chemical S&T Co., Ltd.
Tel
025-025-58367986 18913956109
Fax
QQ:3209878052
Email
amy.xiang@ally-chem.com
Country
China
ProdList
567
Advantage
58
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-0371-55629727 13323845623
Fax
037155629727
Email
2885676761@qq.com
Country
China
ProdList
10110
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Heta Pharm & Chem CO.,Ltd.
Tel
+86-571-88298691 89905385
Fax
+86-571-87353175
Email
sales@hetapharm.com
Country
China
ProdList
72
Advantage
60
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-50664929, 13971561712
Fax
027-50664927 / QQ: 3452835437
Email
hubxys2001@163.com
Country
China
ProdList
1437
Advantage
55
Aikon International Limited
Tel
025-66061636 18013972705
Fax
(3)02557626880
Email
qqyang@aikonchem.com
Country
China
ProdList
15814
Advantage
58
Rhawn Reagent
Tel
400-400-1332688 18019345275
Fax
400-133-2688
Email
amy@rhawn.cn
Country
China
ProdList
14948
Advantage
58
Twochem Co.Ltd.
Tel
021-58111628 15800915896
Fax
QQ 3285589261
Email
sales@twochem.com
Country
China
ProdList
1788
Advantage
58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.
Tel
027-51831887 15337167856
Fax
027-51837635 QQ1165326703
Email
hubeixinyuanshun@163.com
Country
China
ProdList
10295
Advantage
58
Nanjing crow LuNing pharmaceutical technology co., LTD
Tel
13382066392
Country
CHINA
ProdList
4877
Advantage
58
Shanghai Jizhi Biochemical Technology Co. Ltd.
Tel
4009004166/18616739031 18616739031
Email
3007523370@qq.com
Country
China
ProdList
52687
Advantage
58
Shanghai silk sail pharmaceutical technology co., LTD
Tel
18916696128
Email
service@snowpharm.com
Country
China
ProdList
1369
Advantage
58
Cool Pharm, Ltd
Tel
021-58581007 18019463053
Fax
021-50966098
Email
sales@coolpharm.com
Country
China
ProdList
12878
Advantage
58
Beijing Minruida Technology Co., Ltd.
Tel
010-82387566 18001021521;
Fax
82387566-801
Email
sales@mreda.com.cn
Country
China
ProdList
10083
Advantage
58
Chongqing Genco Pharmaceutical Co.,Ltd
Tel
023-88654579 13637703915
Fax
375097861
Email
375097861@qq.com
Country
China
ProdList
282
Advantage
58
Taizhou Crene Biotechnology Co. Ltd.
Tel
+86-0576-88813233 +86-13396860566
Email
sales@pharm-intermediates.com
Country
China
ProdList
1991
Advantage
58
Zhengzhou Alfa Chemical Co.,Ltd
Tel
+8618530059196
Email
sale04@alfachem.cn
Country
China
ProdList
11828
Advantage
58
Hebei Yanxi Chemical Co., Ltd.
Tel
+8618531123677
Email
faithe@yan-xi.com
Country
China
ProdList
5853
Advantage
58
ANHUI WITOP BIOTECH CO., LTD
Tel
+8615255079626
Email
eric@witopchemical.com
Country
China
ProdList
23541
Advantage
58
Hefei TNJ Chemical Industry Co.,Ltd.
Tel
+86-0551-65418684 +8618949823763
Fax
0086-551-65418684
Email
sales@tnjchem.com
Country
China
ProdList
25356
Advantage
58
Hangzhou Proserre Chemical Co.,Ltd.
Tel
+86-571-86088112
Email
info@proserre.com
Country
China
ProdList
1077
Advantage
58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
+86-0571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52846
Advantage
58
AFINE CHEMICALS LIMITED
Tel
+86-0571-85134551
Fax
008657185134895
Email
sales@afinechem.com
Country
China
ProdList
15109
Advantage
58
China fortune way company
Tel
+8610 84669320 17865159269
Fax
+8610 84663776
Email
rnd@sinopharmintl.com
Country
CHINA
ProdList
117
Advantage
58
SIMAGCHEM CORP
Tel
+86-5922680277 +86-13806087780
Email
sale@simagchem.com
Country
China
ProdList
17346
Advantage
58
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Email
chemwill_asia@126.com
Country
CHINA
ProdList
23912
Advantage
58
Shanghai Yanze Chemical Co., Ltd.
Tel
021-021-13773155751 19975051755
Email
260924549@qq.com
Country
China
ProdList
10524
Advantage
58
Chongqing Chemdad Co., Ltd
Tel
+86-023-6139-8061 +86-86-13650506873
Email
sales@chemdad.com
Country
China
ProdList
39927
Advantage
58
Shanghai Yingrui Biopharma Co.,Ltd
Tel
21-33585366
Fax
+86-21-34979012
Email
export01@shyrchem.com
Country
CHINA
ProdList
1319
Advantage
58
Shanghai Kaiwei Chemical Technology Co., Ltd.
Tel
021-58461859 15821823057
Email
service@aiviche.com
Country
China
ProdList
49312
Advantage
58
Henan Weitesi Chemical Technology Co. LTD
Tel
0371-0371-55135753 18003832934
Fax
QQ：2853979818
Email
2853979818@qq.com
Country
China
ProdList
9991
Advantage
58
Chunchuang (Wuhan) Technology Co., Ltd
Tel
15727060112
Email
yutianchun2007@126.com
Country
China
ProdList
9814
Advantage
58
More
Less

View Lastest Price from (7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol 875573-67-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-27
Hebei Yanxi Chemical Co., Ltd.
Product
(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol 875573-67-4
Price
US $40.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-09-19
Career Henan Chemical Co
Product
(7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol 875573-67-4
Price
US $150.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2018-07-27

875573-67-4, (7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diolRelated Search:


  • Estra-1,3,5(10)-triene-3,17-diol, 7-(9-broMononyl)-, (7a,17b)- (9CI)
  • Fulvestrant Intermediates--5-1(N-3-1)
  • Estra-1,3,5(10)-triene-3,17-diol, 7-(9-bromononyl)-, (7α,17β)-
  • (7A,17BETA)-7-(9-BROMONONYL)ESTRA-1,3,5(10)-TRIENE-3,17-DIOL
  • (7α,17β)-7-(9-bromononyl)estra-1,3,5(10)-triene-3,17-diol
  • (7a,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol
  • Fulvestrant interMediate N-2(1)
  • (7R,8R,9S,13S,14S,17S)-7-(9-bromononyl)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
  • Fulvestrant int3
  • (7a,17b)-7-(9-Bromononyl)Estra-1,3,5(10)-Triene-3,17-Diol(For export only)
  • Fulvestrant Impurity 43
  • "(7α,17b)-7-(9-Bromononyl)estra-1,3,5(10)-triene-3,17-diol"
  • Fulvestrant intermediate N-2
  • (7R,8R,9S,13S,14S,17S)-7-(9-Bromononyl)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthrene-3,17-diol
  • Fulvestrant intermediate N-3 hydrolysate
  • 7α-(9-Bromononyl)estra-1,3,5(10)-triene-3,17β-diol
  • 875573-67-4
  • C27H41BrO2