ChemicalBook > CAS DataBase List > Danoprevir

Danoprevir

Product Name
Danoprevir
CAS No.
850876-88-9
Chemical Name
Danoprevir
Synonyms
Danoprevir;RG7227;Intepirdine;CS-64;R7227;RG72277;ITMN-191;RO5190591;Danpprevir;Danoprevir, >=98%
CBNumber
CB02504568
Molecular Formula
C35H46FN5O9S
Formula Weight
731.83
MOL File
850876-88-9.mol
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Danoprevir Property

Melting point:
>165°C (dec.)
Density 
1.41
storage temp. 
-20°C Freezer
solubility 
Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
4.43±0.60(Predicted)
color 
White to Pale Beige
InChI
InChI=1S/C35H46FN5O9S/c1-34(2,3)50-32(45)37-27-13-8-6-4-5-7-11-22-17-35(22,31(44)39-51(47,48)24-14-15-24)38-29(42)28-16-23(19-41(28)30(27)43)49-33(46)40-18-21-10-9-12-26(36)25(21)20-40/h7,9-12,22-24,27-28H,4-6,8,13-20H2,1-3H3,(H,37,45)(H,38,42)(H,39,44)/b11-7+/t22-,23-,27+,28+,35-/m1/s1
InChIKey
ZVTDLPBHTSMEJZ-AIYSODCISA-N
SMILES
C1C2=C(C(F)=CC=C2)CN1C(O[C@H]1CN2C(=O)[C@@H](NC(OC(C)(C)C)=O)CCCCCC=C[C@]3([H])C[C@@]3(C(NS(C3CC3)(=O)=O)=O)NC(=O)[C@]2([H])C1)=O |t:33|
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
24185
Product name
Danoprevir
Purity
≥95%
Packaging
1mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
24185
Product name
Danoprevir
Purity
≥95%
Packaging
5mg
Price
$211
Updated
2024/03/01
Cayman Chemical
Product number
24185
Product name
Danoprevir
Purity
≥95%
Packaging
10mg
Price
$357
Updated
2024/03/01
TRC
Product number
D172820
Product name
Danoprevir
Packaging
5mg
Price
$180
Updated
2021/12/16
TRC
Product number
D172820
Product name
Danoprevir
Packaging
2.5mg
Price
$120
Updated
2021/12/16
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Danoprevir Chemical Properties,Usage,Production

Description

Danoprevir is an orally bioavailable inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A; IC50 = 1 nM), a serine protease essential for HCV replication. It is selective for NS3/4A over a panel of 53 proteases at a concentration of 10 μM. Danoprevir inhibits replication of the HCV genotypes 1a, 1b, 4, 5, and 6 (IC50s = 0.2-0.4 nM) as well as 2b and 3a (IC50s = 1.6 and 3.5 nM, respectively) in vitro. It also reduces the number of HCV genotype 1b replicons in Huh-7 cells (EC50 = 1.8 nM).

Uses

Danoprevir is a selective and potent inhibitor of Hepatitis C virus.

target

HCV NS3/4A protease

Danoprevir Preparation Products And Raw materials

Raw materials

Preparation Products

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Danoprevir Suppliers

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View Lastest Price from Danoprevir manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Danoprevir 850876-88-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10
Zhuozhou Wenxi import and Export Co., Ltd
Product
Danoprevir 850876-88-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-09

850876-88-9, DanoprevirRelated Search:

Everolimus Daclatasvir ABT 737 Telaprevir Trametinib Rapamycin

  • RG7227, ITMN-191, RO5190591
  • 4-Fluoro-1,3-dihydro-2H-isoindole-2-carboxylic acid (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester
  • Danoprevir
  • ITMN-191
  • Danoprevir(ITMN-191)
  • Danoprevir - ITMN 191 | RG 7227 | R 7227
  • 2H-Isoindole-2-carboxylic acid, 4-fluoro-1,3-dihydro-, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dio
  • CS-64
  • ITMN-191; R7227; RO5190591; RG7227;ITMN191;ITMN 191
  • (2R,6S,13aS,14aR,16aS,)-6-((tert-Butoxycarbonyl)amino)-14a-((cyclopropylsulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate
  • RG72277
  • 2H-Isoindole-2-carboxylic acid, 4-fluoro-1,3-dihydro-, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester
  • dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester Danoprevir (ITMN-191)
  • Danoprevir, >=98%
  • Itmn-191 Danoprevir
  • (2R,6S,13aS,14aR,16aS,E)-6-((tert-butoxycarbonyl)aMino)-14a-((cyclopropylsulfonyl)carbaMoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate
  • R7227
  • RG7227
  • RO5190591
  • Danoprevir (RG7227)
  • Danoprevir(ITMN-191, RG7227)
  • (2R,6S,13aS,14aR,16aS,Z)-6-((tert-butoxycarbonyl)amino)-14a-((cyclopropylsulfonyl)carbamoyl)-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl 4-fluoroisoindoline-2-carboxylate
  • Intepirdine
  • Danpprevir
  • Danoprevir ( ITMN191, R7227
  • Danoprevir ITMN-191 Selleck HCV Protease inhibitor
  • Danoprevir(ITMN-191)/RG7227,RO5190591
  • 850876-88-9
  • Inhibitor
  • Inhibitors
  • Coronavirus