ChemicalBook > CAS DataBase List > BTZ043

BTZ043

Product Name
BTZ043
CAS No.
1161233-85-7
Chemical Name
BTZ043
Synonyms
BTZ043;CS-2310;PBTZ 169;BTZ 10526043;BTZ043 raceMate;Unii-G55ZH52P57;BTZ043 (BTZ-043;BTZ043, 10 mM in DMSO;BTZ043;BTZ-043;BTZ 043;2-[(3S)-3-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl]-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one
CBNumber
CB02512406
Molecular Formula
C17H16F3N3O5S
Formula Weight
431.39
MOL File
1161233-85-7.mol
More
Less

BTZ043 Property

Melting point:
190-191°C
Density 
1.68
storage temp. 
-20°C Freezer
solubility 
Chloroform (Slightly), Methanol (Very Slightly)
form 
Solid
color 
White to Pale Yellow
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
22930
Product name
BTZ043
Purity
≥98%
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
22930
Product name
BTZ043
Purity
≥98%
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
22930
Product name
BTZ043
Purity
≥98%
Packaging
10mg
Price
$213
Updated
2024/03/01
Cayman Chemical
Product number
22930
Product name
BTZ043
Purity
≥98%
Packaging
25mg
Price
$485
Updated
2024/03/01
TRC
Product number
B695515
Product name
BTZ043
Packaging
5mg
Price
$85
Updated
2021/12/16
More
Less

BTZ043 Chemical Properties,Usage,Production

Uses

BTZ043 is an inhibitor of the essential flavo-enzyme Decaprenylphosphoryl-beta-D-ribose 2-epimerase (DprE1).

Synthesis

1344087-80-4

1344087-73-5

1161233-85-7

Synthesis of 2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl]-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one (Compound 1) and (2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]decane as 2-(methylsulfanyl)-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one (Compound 1) and (2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]decane. -Trifluoromethyl-4H-1,3-benzothiazin-4-one was carried out in the following general steps: 3.0 g of Compound 1 was suspended in 15 mL of ethanol followed by the addition of 1.5 g of (2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]decane. The reaction mixture was stirred at room temperature and then heated to 50-60°C maintained for 20 minutes. Upon completion of the reaction, it was cooled to room temperature and a light yellow solid was precipitated by adding 100 mL of water. The product was isolated by filtration in 76% yield (calculated based on 2-chloro-3-nitro-5-trifluoromethylbenzamide).

in vivo

Four weeks of treatment with BTZ043 reduces the bacterial burden in the lungs and spleens by 1 and 2 logs, respectively, at the concentrations used. Additional results suggest that BTZ043 efficacy is time-rather than dose-dependent. Acute (5 g/kg) and chronic (25 and 250 mg/kg) toxicology studies in uninfected mice show that, even at the highest dose tested, there are no adverse anatomical, behavioral, or physiological effects after one month[2].

References

[1] Patent: EP2380886, 2011, A1. Location in patent: Page/Page column 8
[2] Patent: WO2011/132070, 2011, A1. Location in patent: Page/Page column 12-13

BTZ043 Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

BTZ043 Suppliers

China 84 India 1 United States 13 Global 98
Shanghai Boyle Chemical Co., Ltd.
Tel
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2922
Advantage
55
BOC Sciences
Tel
1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
12952
Advantage
65
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
Shanghai Witofly Chemical Co.,Ltd
Tel
Email
sales@witofly.com
Country
China
ProdList
2864
Advantage
52
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4800
Advantage
55
D&C Chemicals
Tel
+86-21-58447131
Fax
+86-21-61642470
Email
1724405207@qq.com
Country
China
ProdList
472
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62

1161233-85-7, BTZ043Related Search:

N-Methylformamide DIOXOPROMETHAZINE 2-METHYL-1,3-PROPANEDIOL 1,4-Dioxan-2-one

  • BTZ043
  • BTZ043 raceMate
  • 2-[(2S)-2-Methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl]-8-nitro-6-trifluoromethyl-4H-1,3-benzothiazin-4-one
  • BTZ 10526043
  • PBTZ 169
  • 2-[(3S)-3-methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl]-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one
  • BTZ043 (BTZ-043
  • CS-2310
  • BTZ043;BTZ-043;BTZ 043
  • 4H-1,3-Benzothiazin-4-one, 2-[(2S)-2-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-
  • (S)-2-(2-Methyl-1,4-dioxa-8-azaspiro[4.5]decan-8-yl)-8-nitro-6-(trifluoromethyl)-4H-benzo[e][1,3]thiazin-4-one
  • Unii-G55ZH52P57
  • BTZ043, 10 mM in DMSO
  • 1161233-85-7
  • C17H16F3N3O5S