ChemicalBook > CAS DataBase List > methyl 2-(4-bromo-2-fluorophenyl)acetate
methyl 2-(4-bromo-2-fluorophenyl)acetate
- Product Name
- methyl 2-(4-bromo-2-fluorophenyl)acetate
- CAS No.
- 193290-19-6
- Chemical Name
- methyl 2-(4-bromo-2-fluorophenyl)acetate
- Synonyms
- Methyl 2-(4-bromo-2-fluorophenyl);Methyl 4-bromo-2-fluorophenylacetate;methyl 2-(4-bromo-2-fluorophenyl)acetate;Methyl 4-broMo-2-fluorophenylacetate, 96%;4-bromo-2-fluorophenylacetic acid methyl ester;Benzeneacetic acid, 4-bromo-2-fluoro-, methyl ester
- CBNumber
- CB02512895
- Molecular Formula
- C9H8BrFO2
- Formula Weight
- 247.06
- MOL File
- 193290-19-6.mol
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methyl 2-(4-bromo-2-fluorophenyl)acetate Property
- Boiling point:
- 265.4±25.0 °C(Predicted)
- Density
- 1.519±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- form
- Solid
- Appearance
- Colorless to light yellow Liquid
- CAS DataBase Reference
- 193290-19-6
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Safety
- HS Code
- 2918300090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
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N-Bromosuccinimide Price
Oakwood
- Product number
- 242760
- Product name
- Methyl 2-(4-Bromo-2-fluorophenyl)acetate
- Packaging
- 250mg
- Price
- $39
- Updated
- 2021/12/16
Oakwood
- Product number
- 242760
- Product name
- Methyl 2-(4-Bromo-2-fluorophenyl)acetate
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
AK Scientific
- Product number
- 0015AB
- Product name
- Methyl2-(4-Bromo-2-fluorophenyl)acetate
- Packaging
- 1g
- Price
- $128
- Updated
- 2021/12/16
Oakwood
- Product number
- 242760
- Product name
- Methyl 2-(4-Bromo-2-fluorophenyl)acetate
- Packaging
- 5g
- Price
- $210
- Updated
- 2021/12/16
AK Scientific
- Product number
- 0015AB
- Product name
- Methyl2-(4-Bromo-2-fluorophenyl)acetate
- Packaging
- 5g
- Price
- $271
- Updated
- 2021/12/16
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methyl 2-(4-bromo-2-fluorophenyl)acetate Chemical Properties,Usage,Production
Synthesis
67-56-1
114897-92-6
193290-19-6
The general procedure for the synthesis of methyl 2-fluoro-4-bromophenylacetate from methanol and 2-fluoro-4-bromophenylacetic acid was as follows: a mixture of 2-fluoro-4-bromophenylacetic acid (20.2 g, 86.6 mmol) and concentrated sulfuric acid (7 mL) in methanol (200 mL) was heated and refluxed for 18 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in dichloromethane (200 mL), washed sequentially with saturated sodium bicarbonate solution and brine, and the organic phase was dried with anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to give methyl 2-fluoro-4-bromophenylacetate (21.1 g, 99% yield) as a brown oil. Mass spectrum (ESI): m/z = 280.1 [M + H]+.
References
[1] Patent: WO2017/108723, 2017, A2. Location in patent: Page/Page column 225; 226
[2] Patent: US2014/194383, 2014, A1. Location in patent: Paragraph 0386-0388; 0390
[3] Patent: WO2014/141187, 2014, A1. Location in patent: Page/Page column 54; 55
[4] Patent: WO2016/38519, 2016, A1. Location in patent: Page/Page column 36; 37
[5] Patent: WO2016/38552, 2016, A1. Location in patent: Page/Page column 51
methyl 2-(4-bromo-2-fluorophenyl)acetate Preparation Products And Raw materials
Raw materials
Preparation Products
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