2,6-Dibromo-3-fluoropyridine
- Product Name
- 2,6-Dibromo-3-fluoropyridine
- CAS No.
- 41404-59-5
- Chemical Name
- 2,6-Dibromo-3-fluoropyridine
- Synonyms
- 2,6-Dibromo-3-fluoropyridine;Pyridine, 2,6-dibromo-3-fluoro-
- CBNumber
- CB02513054
- Molecular Formula
- C5H2Br2FN
- Formula Weight
- 254.88
- MOL File
- 41404-59-5.mol
2,6-Dibromo-3-fluoropyridine Property
- Melting point:
- 68-71 °C
- Boiling point:
- 233.8±35.0 °C(Predicted)
- Density
- 2.137±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- -6.07±0.10(Predicted)
- form
- Solid
- color
- White to Off-White
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D425738
- Product name
- 2,6-Dibromo-3-fluoropyridine
- Packaging
- 1g
- Price
- $145
- Updated
- 2021/12/16
- Product number
- FD105956
- Product name
- 2,6-dibromo-3-fluoropyridine
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- FD105956
- Product name
- 2,6-dibromo-3-fluoropyridine
- Packaging
- 1g
- Price
- $200
- Updated
- 2021/12/16
- Product number
- Z4727
- Product name
- 2,6-Dibromo-3-fluoropyridine
- Packaging
- 1g
- Price
- $81
- Updated
- 2021/12/16
- Product number
- FD105956
- Product name
- 2,6-dibromo-3-fluoropyridine
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
2,6-Dibromo-3-fluoropyridine Chemical Properties,Usage,Production
Uses
2,6-Dibromo-3-fluoropyridine is a useful reagent for making GLP-1 receptor agonists.
Synthesis
1133434-13-5
41404-59-5
General procedure for the synthesis of 2,6-dibromo-3-fluoropyridine (37) from the compound (CAS: 1133434-13-5): In a 1L single necked round bottomed flask fitted with a ventilated reflux condenser, raw material 36 (4.00 g, 11.4 mmol) was added so that it was uniformly distributed at the bottom of the flask. The flask was placed in a room temperature oil bath and the temperature of the oil bath was raised to 80°C within 20 minutes and then gradually raised to 130°C within 30 minutes and maintained at this temperature until the feedstock was completely decomposed (solid converted to a viscous substance and gas release stopped). When the reaction was complete, the reaction mixture was cooled to room temperature. The reaction residue was extracted with ether (3 x 75 mL) and the ether extracts were combined. The organic phase was washed with saturated aqueous sodium bicarbonate (200 mL) and subsequently dried over anhydrous sodium sulfate. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure at room temperature to afford the target product 37 in 100% yield (3.00 g) as a yellow solid with a melting point of 47-48 °C.1H NMR (300 MHz, CDCl3) δ 7.44 (dd, 1H, J=3.3,8.4 Hz), 7.31 (m, 1H).
References
[1] Patent: US2009/82330, 2009, A1. Location in patent: Page/Page column 37
2,6-Dibromo-3-fluoropyridine Preparation Products And Raw materials
Raw materials
Preparation Products
2,6-Dibromo-3-fluoropyridine Suppliers
- Tel
- --
- Fax
- --
- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
View Lastest Price from 2,6-Dibromo-3-fluoropyridine manufacturers
- Product
- 2,6-Dibromo-3-fluoropyridine 41404-59-5
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2024-11-12