2-Bromo-5-fluoro-4-iodopyridine

Product Name: 2-Bromo-5-fluoro-4-iodopyridine
CAS No.: 1061357-89-8
Chemical Name: 2-Bromo-5-fluoro-4-iodopyridine
Synonyms: 2-Bromo-5-fluoro-4-iodopyridine;Pyridine, 2-bromo-5-fluoro-4-iodo-
CBNumber: CB02513069
Molecular Formula: C5H2BrFIN
Formula Weight: 301.88
MOL File: 1061357-89-8.mol

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2-Bromo-5-fluoro-4-iodopyridine Property

Boiling point:: 266.8±40.0 °C(Predicted)
Density: 2.412±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
pka: -3.02±0.18(Predicted)
InChI: InChI=1S/C5H2BrFIN/c6-5-1-4(8)3(7)2-9-5/h1-2H
InChIKey: QQLWZJPMEHSISU-UHFFFAOYSA-N
SMILES: C1(Br)=NC=C(F)C(I)=C1

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B692358
Product name: 2-Bromo-5-fluoro-4-iodopyridine
Packaging: 10g
Price: $825
Updated: 2021/12/16

Apolloscientific

Product number: PC445011
Product name: 2-Bromo-5-fluoro-4-iodopyridine
Purity: 98%
Packaging: 250mg
Price: $95
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H32-U-00
Product name: 2-Bromo-5-fluoro-4-iodopyridine
Purity: 98%
Packaging: 250mg
Price: $152
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0363236
Product name: 2-BROMO-5-FLUORO-4-IODOPYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $504.77
Updated: 2021/12/16

Matrix Scientific

Product number: 123620
Product name: 2-Bromo-5-fluoro-4-iodopyridine
Purity: 95+%
Packaging: 1g
Price: $594
Updated: 2021/12/16

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2-Bromo-5-fluoro-4-iodopyridine Chemical Properties,Usage,Production

Synthesis

41404-58-4

1061357-89-8

General procedure for the synthesis of 2-bromo-5-fluoro-4-iodopyridine from 2-bromo-5-fluoropyridine: 2-bromo-5-fluoropyridine (10 g, 56.8 mmol) was dissolved in dry tetrahydrofuran (120 mL) under argon protection, cooled to -78 °C and stirred. A tetrahydrofuran solution of 2 M lithium diisopropylammonium (LDA) (34.1 mL, 68.2 mmol) was slowly added, keeping the temperature at -78 °C. The reaction mixture was stirred at this temperature for 40 min. Subsequently, a tetrahydrofuran (50 mL) solution of iodine (I2, 14.42 g, 56.8 mmol) was added dropwise and stirring was continued at -78 °C for 30 min. Upon completion of the reaction, the reaction was quenched with deionized water (500 mL) and slowly warmed to room temperature. The reaction mixture was extracted with ethyl acetate (2 x 500 mL) and the organic layers were combined. The organic layer was washed with saturated sodium thiosulfate solution (500 mL) to remove unreacted iodine, then dried with anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography using a petroleum ether solution of 3% ethyl acetate as eluent to afford 2-bromo-5-fluoro-4-iodopyridine (12 g, 39.8 mmol, 70% yield). The product was analyzed by LC/MS (ESI), m/e 301.0 [(M + H)+, C5H2BrFIN calculated value, 301.9]; LC/MS retention time (Method E): tR = 0.93 min; 1H NMR (400 MHz, chloroform-d) δ 8.13 (s, 1H), 7.91 (d, J = 4.4 Hz, 1H).

References

[1] Patent: WO2015/2915, 2015, A1. Location in patent: Page/Page column 115
[2] Patent: US2018/141956, 2018, A1. Location in patent: Paragraph 0219
[3] Patent: WO2017/24180, 2017, A1. Location in patent: Page/Page column 299
[4] Patent: WO2018/112094, 2018, A1. Location in patent: Page/Page column 82

2-Bromo-5-fluoro-4-iodopyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Bromo-5-fluoro-4-iodopyridine Suppliers

China 51 India 1 Switzerland 1 United Kingdom 1 United States 10 Global 64

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1061357-89-8, 2-Bromo-5-fluoro-4-iodopyridineRelated Search:

2-Bromo-5-fluoro-4-iodopyridine

Pyridine, 2-bromo-5-fluoro-4-iodo-

1061357-89-8