Methyl 2-bromo-6-fluorobenzoate
- Product Name
- Methyl 2-bromo-6-fluorobenzoate
- CAS No.
- 820236-81-5
- Chemical Name
- Methyl 2-bromo-6-fluorobenzoate
- Synonyms
- Methyl 2-bromo-6-fluorobenzoate;Benzoic acid, 2-bromo-6-fluoro-, methyl ester
- CBNumber
- CB02513584
- Molecular Formula
- C8H6BrFO2
- Formula Weight
- 233.03
- MOL File
- 820236-81-5.mol
Methyl 2-bromo-6-fluorobenzoate Property
- Boiling point:
- 251.3±25.0 °C(Predicted)
- Density
- 1.577±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Colorless to light yellow Liquid
Safety
- HS Code
- 2916399090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
N-Bromosuccinimide Price
- Product number
- M295920
- Product name
- Methyl2-bromo-6-fluorobenzoate
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB70039
- Product name
- 2-Bromo-6-fluorobenzoic acid methyl ester
- Packaging
- 10g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 2723-B-01
- Product name
- Methyl 2-bromo-6-fluorobenzoate
- Packaging
- 1g
- Price
- $61
- Updated
- 2021/12/16
- Product number
- Z0862
- Product name
- 2-Bromo-6-fluorobenzoicacidmethylester
- Packaging
- 1g
- Price
- $70
- Updated
- 2021/12/16
- Product number
- FB70039
- Product name
- 2-Bromo-6-fluorobenzoic acid methyl ester
- Packaging
- 25g
- Price
- $100
- Updated
- 2021/12/16
Methyl 2-bromo-6-fluorobenzoate Chemical Properties,Usage,Production
Synthesis
67-56-1
2252-37-1
820236-81-5
Step 1: Synthesis of methyl 2-bromo-6-fluorobenzoate (2). 2-Bromo-6-fluorobenzoic acid (1, 12.50 g, 57 mmol) was dissolved in a mixture of methanol (60 mL) and concentrated sulfuric acid (65 mL). The reaction mixture was heated to 80 °C and stirred at this temperature for 12 hours. Upon completion of the reaction, the mixture was cooled to room temperature and the pH was adjusted slowly by adding 20% sodium carbonate solution (500 mL) to 8. Subsequently, extraction was carried out with dichloromethane (3 x 180 mL), the organic phases were combined and dried with anhydrous magnesium sulfate. Finally, the solvent was evaporated under reduced pressure to afford the title compound methyl 2-bromo-6-fluorobenzoate (11.29 g, 48.5 mmol, 85% yield) as a brown oil.
References
[1] Patent: WO2011/156786, 2011, A2. Location in patent: Page/Page column 128
[2] Patent: WO2013/86451, 2013, A2. Location in patent: Paragraph 00499
[3] Bioorganic and Medicinal Chemistry Letters, 2015, vol. 25, # 20, p. 4393 - 4398
Methyl 2-bromo-6-fluorobenzoate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Methyl 2-bromo-6-fluorobenzoate manufacturers
- Product
- Methyl 2-bromo-6-fluorobenzoate 820236-81-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2020-01-07