3-Bromo-4-cyanoindole
- Product Name
- 3-Bromo-4-cyanoindole
- CAS No.
- 1186663-64-8
- Chemical Name
- 3-Bromo-4-cyanoindole
- Synonyms
- 3-Bromo-4-cyanoindole;3-Bromo-1H-indole-4-carbonitrile;1H-Indole-4-carbonitrile, 3-bromo-
- CBNumber
- CB02514051
- Molecular Formula
- C9H5BrN2
- Formula Weight
- 221.05
- MOL File
- 1186663-64-8.mol
3-Bromo-4-cyanoindole Property
- Boiling point:
- 405.9±25.0 °C(Predicted)
- Density
- 1.74±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 13.50±0.30(Predicted)
- Appearance
- Off-white to light brown Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B683293
- Product name
- 3-Bromo-4-cyanoindole
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B683293
- Product name
- 3-Bromo-4-cyanoindole
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- Z7938
- Product name
- 3-Bromo-4-cyanoindole
- Packaging
- 25g
- Price
- $532
- Updated
- 2021/12/16
- Product number
- HCH0316488
- Product name
- 3-BROMO-4-CYANOINDOLE
- Purity
- 96.00%
- Packaging
- 5G
- Price
- $1305.15
- Updated
- 2021/12/16
- Product number
- 1186663648
- Product name
- 3-Bromo-4-cyanoindole
- Packaging
- 1g
- Price
- $1735.55
- Updated
- 2021/12/16
3-Bromo-4-cyanoindole Chemical Properties,Usage,Production
Synthesis
16136-52-0
1186663-64-8
General procedure for the synthesis of 3-bromo-4-cyano-1H-indole from 4-cyanoindole: Example 146 Preparation of 1-methyl-3-[3-(4-methylpyridin-3-yl)-2-oxoimidazolidin-1-yl]-1H-indole-4-carbonitrile (146A) Step 1: Synthesis of the intermediate 3-bromo-1H-indole-4-carbonitrile (I-146a) A DMF solution of bromine (0.796 g, 4.975 mmol) was slowly added to a stirred DMF solution (15 mL) of 1H-indole-4-carbonitrile (700 mg, 4.9295 mmol) and the reaction was carried out at room temperature. The reaction mixture was stirred continuously at room temperature for 2 h. The reaction progress was monitored by thin layer chromatography (TLC, unfolding agent was 10% ethyl acetate in hexane solution). Upon completion of the reaction, the mixture was poured into ice water containing 0.5% ammonia and 0.5% sodium bisulfite. The precipitated solid was collected by filtration, washed with cold water and dried to give 850 mg of the target product 3-bromo-1H-indole-4-carbonitrile in 78.41% yield. 1H NMR (DMSO-D6, 300 MHz): δ 12.1 (s, 1H), 8.02-7.49 (m, 3H), 7.42-7.2 (m, 1H).
References
[1] Patent: US2010/331326, 2010, A1. Location in patent: Page/Page column 58
[2] Patent: WO2010/149755, 2010, A1. Location in patent: Page/Page column 148
3-Bromo-4-cyanoindole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Bromo-4-cyanoindole manufacturers
- Product
- 3-Bromo-4-cyanoindole 1186663-64-8
- Price
- US $0.01/KG
- Min. Order
- 1KG
- Purity
- 98%; 99%
- Supply Ability
- 500g； 1kg; 25kg
- Release date
- 2020-01-10