4-methoxy-.alpha.,.alpha.-dimethyl-Benzeneacetic acid
- Product Name
- 4-methoxy-.alpha.,.alpha.-dimethyl-Benzeneacetic acid
- CAS No.
- 2955-46-6
- Chemical Name
- 4-methoxy-.alpha.,.alpha.-dimethyl-Benzeneacetic acid
- Synonyms
- 4-Methoxy-α,α-dimethylbenzeneacetic acid;4-Methoxy-α,α-dimethyl-benzeneacetic acid;Benzeneacetic acid,4-Methoxy-a,a-diMethyl-;2-(4-Methoxyphenyl)-2-methylpropionic acid;Benzeneacetic acid, 4-methoxy-α,α-dimethyl-;Benzeneacetic acid, 4-Methoxy-alpha,alpha-diMethyl-;4-methoxy-.alpha.,.alpha.-dimethyl-Benzeneacetic acid
- CBNumber
- CB02514682
- Molecular Formula
- C11H14O3
- Formula Weight
- 194.23
- MOL File
- 2955-46-6.mol
4-methoxy-.alpha.,.alpha.-dimethyl-Benzeneacetic acid Property
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- Appearance
- White to off-white Solid
Safety
- HazardClass
- IRRITANT
- HS Code
- 2918999090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M329590
- Product name
- 2-(4-Methoxyphenyl)-2-methylpropanoicacid
- Packaging
- 25mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- M329590
- Product name
- 2-(4-Methoxyphenyl)-2-methylpropanoicacid
- Packaging
- 250mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- 054013
- Product name
- 2-(4-Methoxyphenyl)-2-methylpropanoic acid
- Packaging
- 500mg
- Price
- $118
- Updated
- 2021/12/16
- Product number
- 3018AB
- Product name
- 2-(4-Methoxyphenyl)-2-methylpropanoicacid
- Packaging
- 500mg
- Price
- $209
- Updated
- 2021/12/16
- Product number
- 054013
- Product name
- 2-(4-Methoxyphenyl)-2-methylpropanoic acid
- Packaging
- 2.500g
- Price
- $357
- Updated
- 2021/12/16
4-methoxy-.alpha.,.alpha.-dimethyl-Benzeneacetic acid Chemical Properties,Usage,Production
Synthesis
5351-07-5
2955-46-6
Step 24b: 2-(4-Methoxyphenyl)-2-methylpropionitrile (Compound 0802-27, 1.63 g, 9.30 mmol) was dissolved in ethylene glycol (3.40 mL) followed by addition of potassium hydroxide (1.29 g, 22.99 mmol) and water (0.46 mL). The reaction mixture was heated and stirred at 150 °C for 7 hours. Upon completion of the reaction, the mixture was poured into water and the pH was adjusted with concentrated hydrochloric acid to 2. The reaction mixture was filtered, the collected solid was washed with water and dried under vacuum to afford the target product 2-(4-methoxyphenyl)-2-methylpropanoic acid (Compound 0803-27, 0.85 g, 47% yield) as a white solid. The product was analyzed by LCMS showing [M+1]+ of 195. 1H NMR (DMSO-d6) data were as follows: δ 1.44 (s, 6H), 3.73 (s, 3H), 6.88 (d, J=9.2 Hz, 2H), 7.25 (d, J=8.4 Hz, 2H), 12.23 (s, 1H).
References
[1] European Journal of Organic Chemistry, 2007, # 21, p. 3449 - 3462
[2] Patent: WO2009/36016, 2009, A1. Location in patent: Page/Page column 77; 78
[3] Acta Chemica Scandinavica (1947-1973), 1954, vol. 8, p. 1203,1207
[4] Acta Chemica Scandinavica (1947-1973), 1955, vol. 9, p. 210,214
[5] Journal of the American Chemical Society, 1956, vol. 78, p. 4801,4805
4-methoxy-.alpha.,.alpha.-dimethyl-Benzeneacetic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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