MK-7246

Product Name: MK-7246
CAS No.: 1218918-62-7
Chemical Name: MK-7246
Synonyms: CS-2898;MK-7246;MK7246;MK 7246;MK7246;MK 7246;MK-7246;ethyl 2-(7-(4-fluoro-N-MethylphenylsulfonaMido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate;(7R)-7-[[(4-Fluorophenyl)sulfonyl]methylamino]-6,7,8,9-tetrahydropyrido[1,2-a]indole-10-acetic acid;(R)-2-(7-(4-fluoro-N-MethylphenylsulfonaMido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid;2-[(7R)-7-[(4-FLUOROPHENYL)SULFONYL-METHYLAMINO]-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL-10-YL]ACETIC ACID;Pyrido[1,2-a]indole-10-acetic acid, 7-[[(4-fluorophenyl)sulfonyl]methylamino]-6,7,8,9-tetrahydro-, (7R)-
CBNumber: CB02516060
Molecular Formula: C21H21FN2O4S
Formula Weight: 416.47
MOL File: 1218918-62-7.mol

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MK-7246 Property

Boiling point:: 636.5±65.0 °C(Predicted)
Density: 1.41±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:250.0(Max Conc. mg/mL);600.28(Max Conc. mM)
form: A solid
pka: 4.50±0.10(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: M425045
Product name: MK-7246
Packaging: 25mg
Price: $1540
Updated: 2021/12/16

ChemScene

Product number: CS-0009391
Product name: MK-7246
Purity: 98.16%
Packaging: 50mg
Price: $1800
Updated: 2021/12/16

ChemScene

Product number: CS-0009391
Product name: MK-7246
Purity: 98.16%
Packaging: 5mg
Price: $330
Updated: 2021/12/16

ChemScene

Product number: CS-0009391
Product name: MK-7246
Purity: 98.16%
Packaging: 10mg
Price: $600
Updated: 2021/12/16

ChemScene

Product number: CS-0009391
Product name: MK-7246
Purity: 98.16%
Packaging: 100mg
Price: $2400
Updated: 2021/12/16

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MK-7246 Chemical Properties,Usage,Production

Uses

MK-7246 is a potent and selective CRTH2 antagonist for the treatment of respiratory diseases.

in vivo

Whether the inhibition of a clinically-relevant mechanism of allergic lung inflammation such as CRTH2 will lead to a suppression of inflammatory responses is investigated in A. alternata challenged Brown Norway rats (n=8 per group). Mast cell derived production of Prostaglandin D₂ (PGD₂) is believed to be a prime mediator of allergic inflammation. Since CRTH2 plays an important role in the early aspects of the allergic inflammation cascade, the effect of the CRTH2 antagonist is examined on A. alternate elicited pulmonary inflammatory responses. CRTH2 inhibitor MK-7246 is orally administered 1 h before and 23 h post-intratracheal instillation of the A. alternata. MK-7246 produces a dose dependent decrease in the number of eosinophils with a maximal inhibition of 74±5% in the 100 mg/kg group (P<0.05), IL-5 (80±12%) and IL-13 (76±14%) cytokines levels (P<0.05) ^[2].

IC 50

DP: 2.5 nM (Ki); TP: 3804 nM (Ki)

MK-7246 Preparation Products And Raw materials

Raw materials

Preparation Products

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MK-7246 Suppliers

China 42 United States 6 Global 48

Shanghai Boyle Chemical Co., Ltd.

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ShangHai Onsyn-Chemical Technology Co., Ltd.

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shanghai cooperpharm co.,LTD .

Tel: +86-021-58975553
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Shanghai Lollane Biological Technology Co.,Ltd.

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Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
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Email: info@efebio.com
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Amadis Chemical Company Limited

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Chuzhou KeMail Chemical Technology Co., Ltd

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Kaixin Chemical (Hong Kong) Limited

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Shanghai Biopharmaleader Co., Ltd.

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Nanjing SynTitan Pharmaceutical Co., Ltd.

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1218918-62-7, MK-7246Related Search:

MK-7246

(R)-2-(7-(4-fluoro-N-MethylphenylsulfonaMido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetic acid

ethyl 2-(7-(4-fluoro-N-MethylphenylsulfonaMido)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)acetate

2-[(7R)-7-[(4-FLUOROPHENYL)SULFONYL-METHYLAMINO]-6,7,8,9-TETRAHYDROPYRIDO[1,2-A]INDOL-10-YL]ACETIC ACID

(7R)-7-[[(4-Fluorophenyl)sulfonyl]methylamino]-6,7,8,9-tetrahydropyrido[1,2-a]indole-10-acetic acid

CS-2898

MK7246;MK 7246;MK-7246

MK7246;MK 7246

Pyrido[1,2-a]indole-10-acetic acid, 7-[[(4-fluorophenyl)sulfonyl]methylamino]-6,7,8,9-tetrahydro-, (7R)-

1218918-62-7