ChemicalBook > CAS DataBase List > 4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one

4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one

Product Name
4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one
CAS No.
1257326-24-1
Chemical Name
4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one
Synonyms
GSK-789472 HCl;GSK 789472 hydrochloride;Dopamine D2 receptor agonist-3;5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one;4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one;1-Phenyl-3-(piperidin-2-ylmethyl)imidazolidin-2-one hydrochloride;4,5-dihydro-1-phenyl-3- (2-piperidinyl) methylimidazole-2 (1H) - one
CBNumber
CB02518695
Molecular Formula
C15H21N3O.HCl
Formula Weight
295.80768
MOL File
1257326-24-1.mol
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4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one Property

Melting point:
233-236°C
storage temp. 
Desiccate at RT
solubility 
Chloroform (Slightly, Sonicated), Methanol (Slightly)
form 
Solid
color 
White to Off-White
Stability:
Hygroscopic
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
G797805
Product name
GSK789472Hydrochloride
Packaging
10mg
Price
$145
Updated
2021/12/16
TRC
Product number
G797805
Product name
GSK789472Hydrochloride
Packaging
25mg
Price
$295
Updated
2021/12/16
Usbiological
Product number
255411
Product name
GSK 789472 hydrochloride
Packaging
10mg
Price
$423
Updated
2021/12/16
ApexBio Technology
Product number
B7543
Product name
GSK789472hydrochloride
Packaging
50mg
Price
$1158
Updated
2021/12/16
ApexBio Technology
Product number
B7543
Product name
GSK789472hydrochloride
Packaging
10mg
Price
$266
Updated
2021/12/16
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4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one Chemical Properties,Usage,Production

Uses

GSK 789472 Hydrochloride is a dopamine D3 receptor (D3R) partial agonist. a specific D3DR antagonist and D2DR partial agonist.

in vivo

Dopamine D2 receptor agonist-3 (3 mg/kg, s.c.) shows high brain penetration (brain to blood ratio of 5.5) and Tmax of 0.5 h[1].

IC 50

D2 Receptor: 5 nM (EC50); D3 Receptor: >3.2 μM (EC50)

4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one Suppliers

China 32 India 1 United Kingdom 1 United States 6 USA 1 Global 41
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
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3bsc@sina.com
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China
ProdList
15838
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EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
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Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
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SHANGHAI FDC-CHEMICAL CO.,LTD
Tel
021-61469567 13482353728
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sales@fdc-chemical.com
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China
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Shanghai Maruhua Science and Technology Co. Ltd.
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021-57171708 18721745940
Fax
QQ1139783351
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sales@api-chem.com
Country
China
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Changzhou Ansciep Chemical Co., Ltd.
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0519-86305871 13961213398
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tina@ansciepchem.com
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China
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TargetMol Chemicals Inc.
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marketing@targetmol.com
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United States
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ShanghaiFineBiotechCoLtd
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CHINA
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Shanghai TenSus Biotechnology Co., Ltd.
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Tianjin and Sinde Biotechnology Co., Ltd.
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1257326-24-1, 4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-oneRelated Search:


  • 4,5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one
  • GSK 789472 hydrochloride
  • 1-Phenyl-3-(piperidin-2-ylmethyl)imidazolidin-2-one hydrochloride
  • 5-Dihydro-1-phenyl-3-(2-piperidinyl)methylimidazol-2(1H)-one
  • GSK-789472 HCl
  • 4,5-dihydro-1-phenyl-3- (2-piperidinyl) methylimidazole-2 (1H) - one
  • Dopamine D2 receptor agonist-3
  • 1257326-24-1
  • C15H21N3OHCl