ChemicalBook > CAS DataBase List > PF 3845

PF 3845

Product Name
PF 3845
CAS No.
1196109-52-0
Chemical Name
PF 3845
Synonyms
CS-124;PF 3845;PF3845/PF-3845;PF 3845 hydrate;PF 3845 USP/EP/BP;PF-3845;PF 3845;PF3845;PF-3845, 10 mM in DMSO;PF-3845, FAAH inhibitor;4-(3-(5-(trifluoromethyl)pyridin-2-yloxy)benzyl)-N-(pyridin-3-yl)piperidine-1-carboxamide;N-(Pyridin-3-yl)-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzyl)piperidine-1-carboxamide
CBNumber
CB02518802
Molecular Formula
C24H23F3N4O2
Formula Weight
456.46
MOL File
1196109-52-0.mol
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PF 3845 Property

Boiling point:
623.6±55.0 °C(Predicted)
Density 
1.323±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥45mg/mL
pka
14.14±0.40(Predicted)
form 
powder
color 
white to tan
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0158
Product name
PF 3845 hydrate
Purity
≥98% (HPLC)
Packaging
5mg
Price
$131
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0158
Product name
PF 3845 hydrate
Purity
≥98% (HPLC)
Packaging
25mg
Price
$199.6
Updated
2024/03/01
Cayman Chemical
Product number
13279
Product name
PF-3845
Purity
≥98%
Packaging
1mg
Price
$29
Updated
2024/03/01
Cayman Chemical
Product number
13279
Product name
PF-3845
Purity
≥98%
Packaging
5mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
13279
Product name
PF-3845
Purity
≥98%
Packaging
10mg
Price
$216
Updated
2024/03/01
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PF 3845 Chemical Properties,Usage,Production

Uses

Fatty acid amide hydrolase (FAAH) degrades N-acyl ethanolamines (NAEs), including the endocannabinoid arachidonoyl ethanolamide (AEA). PF-3845 is a potent, selective, and irreversible inhibitor of FAAH (Ki = 0.23 μM). It covalently binds FAAH on Ser241 at the catalytic site, resulting in prolonged elevation of AEA in the brain and plasma in rats after treatment. PF-3845 significantly and persistently reduces inflammatory pain in rats through a cannabinoid receptor-dependent mechanism.[Cayman Chemical]

Definition

ChEBI: N-(3-pyridinyl)-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide is a member of piperidines.

Biological Activity

pf-3845 is a highly potent and selective inhibitor of fatty acid amide hydrolase (faah) with ki value of 0.23μm [1].pf-3845 is a biaryl ether piperidine. it inhibits faah by a covalent, irreversible mechanism involving carbamylating faah's catalytic s241 nucleophile. it is found that, administration of pf-3845 to mice results a rapid and complete inactivation of faah in the brain. pf-3845 is highly selective for faah in vivo. it shows no activity to some other serine hydrolases as well as to a faah homologue, faah2. in addition, pf-3845-treated mice shows significant elevations in brain levels of aea, other naes and liver levels of aea, pea and oea. moreover, pf-3845 is found to inhibit pain responses in a rat model of inflammatory pain. it is also found to reverse lps-induced tactile allodynia in mice. this anti-allodynic effect requires activation of both cb1 and cb2 receptors which are the target receptors of the faah substrates [1, 2].

Biochem/physiol Actions

PF 3845 is a potent, irreversible inhibitor of fatty acid amide hydrolase (FAAH), the principle enzyme involved in the degradation of the endocannabinoid anandamide. The endocannabinoid system is a target for therapeutic pain relief. PF-3845 is a covalent inhibitor that carbamylates FAAH′s serine nucleophile. It high selectivity over other enzymes including FAAH-2. In mouse studies, PF-3845 has been shown to raise brain anandamide levels for up to 24 hr; and in a rat model it produced significant reduction of inflammatory pain..

storage

Store at +4°C

References

[1] ahn k, johnson ds, mileni m, beidler d, long jz, mckinney mk, weerapana e, sadagopan n, liimatta m, smith se, lazerwith s, stiff c, kamtekar s, bhattacharya k, zhang y, swaney s, van becelaere k, stevens rc, cravatt bf. discovery and characterization of a highly selective faah inhibitor that reduces inflammatory pain. chem biol. 2009 apr 24;16(4):411-20.
[2] booker l, kinsey sg, abdullah ra, blankman jl, long jz, ezzili c, boger dl, cravatt bf, lichtman ah. the fatty acid amide hydrolase (faah) inhibitor pf-3845 acts in the nervous system to reverse lps-induced tactile allodynia in mice. br j pharmacol. 2012 apr;165(8):2485-96.

PF 3845 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF 3845 Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
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96815
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3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15839
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Chembest Research Laboratories Limited
Tel
+86-21-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6005
Advantage
61
VDM Biochemicals
Tel
0330-2528181
Fax
0330-2528171
Email
sales@vdmbio.com
Country
United States
ProdList
510
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Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Dalian Meilun Biotech Co., Ltd.
Tel
0411-62910999 13889544652
Email
sales@meilune.com
Country
China
ProdList
4727
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58
NCE Biomedical Co.,Ltd.
Tel
4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
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+86-27-87599188
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China
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Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
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Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
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MedChemexpress LLC
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021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
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4861
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View Lastest Price from PF 3845 manufacturers

Career Henan Chemical Co
Product
PF 3845 1196109-52-0
Price
US $9.80/KG
Min. Order
1g
Purity
≥99%
Supply Ability
100kg
Release date
2019-12-24

1196109-52-0, PF 3845Related Search:


  • PF3845/PF-3845
  • N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide
  • PF 3845
  • 4-(3-(5-(trifluoromethyl)pyridin-2-yloxy)benzyl)-N-(pyridin-3-yl)piperidine-1-carboxamide
  • N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide PF 3845
  • N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxamide hydrate
  • PF 3845 hydrate
  • N-3-Pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-1-piperidinecarboxami
  • N-pyridin-3-yl-4-[[3-[5-(trifluoromethyl)pyridin-2-yl]oxyphenyl]methyl]piperidine-1-carboxamide
  • CS-124
  • N-(Pyridin-3-yl)-4-(3-((5-(trifluoromethyl)pyridin-2-yl)oxy)benzyl)piperidine-1-carboxamide
  • PF-3845;PF 3845;PF3845
  • 1-Piperidinecarboxamide, N-3-pyridinyl-4-[[3-[[5-(trifluoromethyl)-2-pyridinyl]oxy]phenyl]methyl]-
  • PF 3845 USP/EP/BP
  • PF-3845, FAAH inhibitor
  • PF-3845, 10 mM in DMSO
  • 1196109-52-0
  • Inhibitors
  • Inhibitor
  • Pharmaceutical intermediate