(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanonehydrochloride

Product Name: (2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanonehydrochloride
CAS No.: 372523-75-6
Chemical Name: (2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanonehydrochloride
Synonyms: TCS OX2 29;TCS-OX2-29, CID 10408514;TCS-OX2-29, 10 mM in DMSO;TCS OX2 29, Orexin-2 receptor antagonist;(2S)-1-(6,7-DIMETHOXY-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-3,3-DIMETHYL-2-(PYRIDIN-4-YLMETHYLAMINO)BUTAN-1-ONE;(S)-1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3,3-dimethyl-2-((pyridin-4-ylmethyl)amino)butan-1-one;1-Butanone, 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-, (2S)-;(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanonehydrochloride
CBNumber: CB02518897
Molecular Formula: C23H31N3O3
Formula Weight: 397.51
MOL File: 372523-75-6.mol

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(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanonehydrochloride Property

storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: DMSO : 25 mg/mL (62.89 mM; Need ultrasonic)Ethanol : 25 mg/mL (62.89 mM; Need ultrasonic)H2O : < 0.1 mg/mL (insoluble)
form: Powder
color: White to off-white
Water Solubility: H2O: ≥2.0mg/mL, clear

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Tocris

Product number: 3371
Product name: TCSOX229
Purity: ≥98%(HPLC)
Packaging: 10
Price: $227
Updated: 2021/12/16

Tocris

Product number: 3371
Product name: TCSOX229
Purity: ≥98%(HPLC)
Packaging: 50
Price: $952
Updated: 2021/12/16

Usbiological

Product number: 256888
Product name: TCS OX2 29
Packaging: 10mg
Price: $502
Updated: 2021/12/16

TRC

Product number: T127355
Product name: TCSOX229
Packaging: 10mg
Price: $205
Updated: 2021/12/16

ChemScene

Product number: CS-5761
Product name: TCS-OX2-29
Purity: 99.82%
Packaging: 100mg
Price: $1188
Updated: 2021/12/16

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(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanonehydrochloride Chemical Properties,Usage,Production

Uses

TCS OX2 29 is a potent and selective orexin-2 receptor (OX2) antagonist.

Biological Activity

TCS OX2 29 or TCS-OX2-29 is a potent and selective orexin 2 receptor (Ox2R, Ox2-R, Ox-2-R) antagonist (IC50 = 40 nM/Ox2R, >10 μM/Ox1R) with little potency toward 50 other receptors, ion channels, and transporters tested (<30% inhibition at 10 μM). TCS OX2 29 is widely used for elucidating various physiological functions mediated by Ox2R both in cultures and in mice and rats in vivo.

in vivo

TCS-OX2-29 (5-10 mg/kg; intraperitoneal injection; adult male NMRI mice) treatment suppresses conditioned place preference (CPP) acquisition and expression in both na ve and dependent mice significantly^[2].

Animal Model:	440 adult male NMRI mice (25-30 g)^[2]
Dosage:	5 mg/kg and 10 mg/kg
Administration:	Intraperitoneal injection (Pharmacokinetic study)
Result:	Suppressed conditioned place preference (CPP) acquisition and expression in both na?ve and dependent mice significantly.

IC 50

OX₂ Receptor

(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanonehydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanonehydrochloride Suppliers

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372523-75-6, (2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanonehydrochlorideRelated Search:

(2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanonehydrochloride

TCS OX2 29

(2S)-1-(6,7-DIMETHOXY-3,4-DIHYDRO-1H-ISOQUINOLIN-2-YL)-3,3-DIMETHYL-2-(PYRIDIN-4-YLMETHYLAMINO)BUTAN-1-ONE

TCS-OX2-29, CID 10408514

1-Butanone, 1-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-, (2S)-

(S)-1-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)-3,3-dimethyl-2-((pyridin-4-ylmethyl)amino)butan-1-one

TCS OX2 29, Orexin-2 receptor antagonist

TCS-OX2-29, 10 mM in DMSO

372523-75-6

C23H31N3O3HCl