5-[3-(Ethylsulfonyl)phenyl]-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-9H-pyrido[2,3-b]indole-7-carboxamide

Product Name: 5-[3-(Ethylsulfonyl)phenyl]-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-9H-pyrido[2,3-b]indole-7-carboxamide
CAS No.: 934541-31-8
Chemical Name: 5-[3-(Ethylsulfonyl)phenyl]-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-9H-pyrido[2,3-b]indole-7-carboxamide
Synonyms: TAK-901;CS-7;TAK-91;AKT-901;TAK-901/TAK901;TAK-901 AKSci X7460 TAK901;5-[3-(Ethylsulfonyl)phenyl]-3,8-diMethyl-N-(1-Methyl-4-;5-(3-(Ethylsulfonyl)phenyl)-3,8-dimethyl-N-(1-methylpiperidin-4-yl)-9H-pyrido[2,3-b]indole-7-c;5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-N-(1-methylpiperidin-4-yl)-9H-pyrido[2,3-b]indole-7-carboxamide;5-[3-(Ethylsulfonyl)phenyl]-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-9H-pyrido[2,3-b]indole-7-carboxamide
CBNumber: CB02521189
Molecular Formula: C28H32N4O3S
Formula Weight: 504.64
MOL File: 934541-31-8.mol

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5-[3-(Ethylsulfonyl)phenyl]-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-9H-pyrido[2,3-b]indole-7-carboxamide Property

Density: 1.33
storage temp.: Store at -20°C
solubility: ≥25.25 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form: solid
color: Off-white to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML2155
Product name: TAK-901
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $94.2
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML2155
Product name: TAK-901
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $306
Updated: 2024/03/01

Cayman Chemical

Product number: 23772
Product name: TAK-901
Purity: ≥98%
Packaging: 1mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 23772
Product name: TAK-901
Purity: ≥98%
Packaging: 5mg
Price: $202
Updated: 2024/03/01

Cayman Chemical

Product number: 23772
Product name: TAK-901
Purity: ≥98%
Packaging: 10mg
Price: $384
Updated: 2024/03/01

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5-[3-(Ethylsulfonyl)phenyl]-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-9H-pyrido[2,3-b]indole-7-carboxamide Chemical Properties,Usage,Production

Uses

A novel Aurora B kinase inhibitor with potential antineoplastic activity. It binds to and inhibits the activity of Aurora B, which may result in a decrease in the proliferation of tumor cells that overexpress Aurora B. Aurora B is a positive regulator of mitosis that functions in the attachment of the mitotic spindle to the centromere; the segregation of sister chromatids to each daughter cell; and the separation of daughter cells during cytokinesis. It is a COVID19-related research product.

Biological Activity

protein kinases aurora a, b, and c play crucial roles during mitosis and cell division, are frequently elevated in cancer, and represent attractive targets for therapeutic intervention. tak-901 is a novel, multitargeted aurora b kinase inhibitor derived from a novel azacarboline kinase hinge-binder chemotype.

in vitro

tak-901 exhibited time-dependent, tight-binding inhibition of aurora b, but not aurora a. consistently, tak-901 suppressed cellular histone h3 phosphorylation and induced polyploidy. in various human cancer cell lines, tak-901 inhibited cell proliferation with effective concentration values from 40 to 500 nmol/l. tak-901 potently inhibited only a few kinases other than aurora b in intact cells, including flt3 and fgfr2 [1].

in vivo

in rodent xenografts, tak-901 exhibited potent activity against multiple human solid tumor types, and complete regression was found in the ovarian cancer a2780 model. in vivo biomarker studies showed that tak-901 induced pd responses consistent with aurora b inhibition and correlating with retention of tak-901 in tumor tissue. [2].

target

Aurora A

IC 50

0.0017, 0.021 for aurora-b/incenp and aurora-a/tpx2, respectively

References

[1] farrell p, shi l, matuszkiewicz j, balakrishna d, hoshino t, zhang l, elliott s, fabrey r, lee b, halkowycz p, sang b, ishino s, nomura t, teratani m, ohta y, grimshaw c, paraselli b, satou t, de jong r. biological characterization of tak-901, an investigational, novel, multitargeted aurora b kinase inhibitor. mol cancer ther. 2013;12(4):460-70.

5-[3-(Ethylsulfonyl)phenyl]-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-9H-pyrido[2,3-b]indole-7-carboxamide Preparation Products And Raw materials

Raw materials

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5-[3-(Ethylsulfonyl)phenyl]-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-9H-pyrido[2,3-b]indole-7-carboxamide Suppliers

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View Lastest Price from 5-[3-(Ethylsulfonyl)phenyl]-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-9H-pyrido[2,3-b]indole-7-carboxamide manufacturers

Career Henan Chemical Co

Product: TAK-901 934541-31-8
Price: US $1000.00-950.00/KG
Min. Order: 1G
Purity: 98%
Supply Ability: 100kg
Release date: 2018-08-04

934541-31-8, 5-[3-(Ethylsulfonyl)phenyl]-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-9H-pyrido[2,3-b]indole-7-carboxamideRelated Search:

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5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-N-(1-methylpiperidin-4-yl)-9H-pyrido[2,3-b]indole-7-carboxamide

5-[3-(Ethylsulfonyl)phenyl]-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-9H-pyrido[2,3-b]indole-7-carboxamide TAK-901

TAK-91

5-(3-(Ethylsulfonyl)phenyl)-3,8-dimethyl-N-(1-methylpiperidin-4-yl)-9H-pyrido[2,3-b]indole-7-c

TAK-901/TAK901

5-[3-(Ethylsulfonyl)phenyl]-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-9H-pyrido[2,3-b]indole-7-carboxamide

CS-7

9H-Pyrido[2,3-b]indole-7-carboxamide, 5-[3-(ethylsulfonyl)phenyl]-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-

TAK-901

AKT-901

5-[3-(Ethylsulfonyl)phenyl]-3,8-diMethyl-N-(1-Methyl-4-

5-[3-(Ethylsulfonyl)phenyl]-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-9H-pyrido[2,3-b]indole-7-carboxamide ISO 9001：2015 REACH

TAK-901 AKSci X7460 TAK901

934541-31-8

Inhibitors

Inhibitor

Heterocycles

Intermediates & Fine Chemicals

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Protein Kinase Inhibitors and Activators

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