ChemicalBook > CAS DataBase List > PF03716556

PF03716556

Product Name
PF03716556
CAS No.
928774-43-0
Chemical Name
PF03716556
Synonyms
CS-1022;PF 3716556;PF03716556;PF03716556 USP/EP/BP;PF-3716556 PF3716556;PF-03716556; PF03716556;PF3716556/PF-3716556/PF-03716556;PF-3716556;PF-03716556; PF03716556;(R)-N-(2-Hydroxyethyl)-N,2-dimethyl-8-((5-methylchroman-4-yl)amino)imidazo[1,2-a]pyridine-6-ca;(R)-N-(2-Hydroxyethyl)-N,2-dimethyl-8-((5-methylchroman-4-yl)amino)imidazo[1,2-a]pyridine-6-carboxamide
CBNumber
CB02526164
Molecular Formula
C22H26N4O3
Formula Weight
394.47
MOL File
928774-43-0.mol
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PF03716556 Property

Melting point:
143-145°C
Density 
1.30
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
DMSO: ≥10mg/mL
form 
powder
pka
14.18±0.10(Predicted)
color 
white to tan
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0155
Product name
PF-03716556
Purity
≥98% (HPLC)
Packaging
5mg
Price
$117
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0155
Product name
PF-03716556
Purity
≥98% (HPLC)
Packaging
25mg
Price
$545
Updated
2023/06/20
Cayman Chemical
Product number
17710
Product name
PF-3716556
Purity
≥98%
Packaging
5mg
Price
$62
Updated
2024/03/01
Cayman Chemical
Product number
17710
Product name
PF-3716556
Purity
≥98%
Packaging
10mg
Price
$109
Updated
2024/03/01
Cayman Chemical
Product number
17710
Product name
PF-3716556
Purity
≥98%
Packaging
25mg
Price
$225
Updated
2024/03/01
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PF03716556 Chemical Properties,Usage,Production

Chemical Properties

Light Tan Solid

Uses

A novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease.

Biological Activity

the gastric h+,k+-atpase, which is responsible for gastric acid secretion, is a p2-type atpase located in the apical membrane of parietal cells. inhibition of the h+,k+-atpase is currently the most effective way to control gastric acid secretion and remains an attractive target for the medical treatment of acidrelated diseases. pf-03716556 is a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease.

in vitro

pf-03716556 demonstrated 3-fold greater inhibitory activity than revaprazan, the only acid pump antagonist that has been available on the market, in ion-tight assay. kinetics experiments revealed that pf-03716556 has a competitive and reversible mode of action [1].

in vivo

pf-03716556 did not display any species differences, exhibiting highly selective profile including the canine kidney h+,k+-atpase. in addition, more rapid onset of action than omeprazole and 3-fold greater potency than revaprazan were observed in ghosh-schild rats and heidenhain pouch dogs [2].

IC 50

in porcine ion-tight membrane vesicles, pf-03716556 inhibited h+,k+-atpase activity in a concentration-dependent manner, with a pic50 value of 7.095 ± 0.077 at ph 7.4.

storage

-20°C

References

[1] mori h, tonai-kachi h, ochi y, taniguchi y, ohshiro h, takahashi n, aihara t, hirao a, kato t, sakakibara m, kurebayashi y. n-(2-hydroxyethyl)-n,2-dimethyl-8-{[(4r)-5-methyl-3,4- dihydro-2h-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide (pf-03716556), a novel, potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease. j pharmacol exp ther. 2009;328(2):671-9.

PF03716556 Preparation Products And Raw materials

Raw materials

Preparation Products

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PF03716556 Suppliers

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928774-43-0, PF03716556Related Search:

G-STROPHANTHIN

  • 8-[[(4R)-3,4-Dihydro-5-Methyl-2H-1-benzopyran-4-yl]aMino]-N-(2-hydroxyethyl)-N,2-diMethyliMidazo[1,2-a]pyridine-6-carboxaMide
  • N-(2-Hydroxyethyl)-N,2-diMethyl-8-{[(4R)-5-Methyl-3,4-dihydro-2H-chroMen-4-yl]aMino}iMidazo[1,2-a]pyridine-6-carboxa
  • (R)-N-(2-hydroxyethyl)-N,2-dimethyl-8-(5-methyl-3,4-dihydro-2H-chromen-4-ylamino)H-imidazo[1,2-a]pyridine-6-carboxamide
  • 8-[[(4R)-3,4-Dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethylimidazo[1,2-a]pyridine-6-carboxamide PF 03716556
  • [N-(2-Hydroxyethyl)-N,2-dimethyl-8-{[(4R)-5-methyl-3,4-dihydro-2H-chromen-4-yl]amino}imidazo[1,2-a]pyridine-6-carboxamide]
  • PF03716556
  • PF 3716556
  • PF-3716556;PF-03716556; PF03716556
  • (R)-N-(2-Hydroxyethyl)-N,2-dimethyl-8-((5-methylchroman-4-yl)amino)imidazo[1,2-a]pyridine-6-ca
  • PF3716556/PF-3716556/PF-03716556
  • PF-03716556; PF03716556
  • CS-1022
  • Imidazo[1,2-a]pyridine-6-carboxamide, 8-[[(4R)-3,4-dihydro-5-methyl-2H-1-benzopyran-4-yl]amino]-N-(2-hydroxyethyl)-N,2-dimethyl-
  • PF03716556 USP/EP/BP
  • (R)-N-(2-Hydroxyethyl)-N,2-dimethyl-8-((5-methylchroman-4-yl)amino)imidazo[1,2-a]pyridine-6-carboxamide
  • PF-3716556 PF3716556
  • 928774-43-0
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