7-CHLORO-5-METHYL-1H-PYRAZOLO[4,3-B]PYRIDINE

Product Name: 7-CHLORO-5-METHYL-1H-PYRAZOLO[4,3-B]PYRIDINE
CAS No.: 94220-38-9
Chemical Name: 7-CHLORO-5-METHYL-1H-PYRAZOLO[4,3-B]PYRIDINE
Synonyms: 7-CHLORO-5-METHYL-1H-PYRAZOLO[4,3-B]PYRIDINE;1H-Pyrazolo[4,3-b]pyridine, 7-chloro-5-Methyl-
CBNumber: CB0252779
Molecular Formula: C7H6ClN3
Formula Weight: 167.6
MOL File: 94220-38-9.mol

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7-CHLORO-5-METHYL-1H-PYRAZOLO[4,3-B]PYRIDINE Property

Boiling point:: 307.3±37.0 °C(Predicted)
Density: 1.438±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 9.09±0.40(Predicted)
Appearance: Light brown to brown Solid
InChI: InChI=1S/C7H6ClN3/c1-4-2-5(8)7-6(10-4)3-9-11-7/h2-3H,1H3,(H,9,11)
InChIKey: GTYZRPHAMFVUEE-UHFFFAOYSA-N
SMILES: C12C=NNC1=C(Cl)C=C(C)N=2

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C993600
Product name: 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine
Packaging: 100mg
Price: $90
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC144365
Product name: 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine
Packaging: 50mg
Price: $54
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC144365
Product name: 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine
Packaging: 100mg
Price: $94
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC144365
Product name: 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine
Packaging: 250mg
Price: $187.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC144365
Product name: 7-Chloro-5-methyl-1H-pyrazolo[4,3-b]-pyridine
Packaging: 500mg
Price: $325
Updated: 2021/12/16

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7-CHLORO-5-METHYL-1H-PYRAZOLO[4,3-B]PYRIDINE Chemical Properties,Usage,Production

Synthesis

268547-52-0

94220-38-9

Step 1: 5-methyl-1H-pyrazolo[4,3-b]pyridin-7-ol (4.58 g, 30.7 mmol) was dissolved in phosphorochloridic acid (30 mL) and the reaction was heated at 110 °C for 30 min. Upon completion of the reaction, the mixture was cooled to room temperature and subsequently slowly poured into ice water. The pH of the mixture was adjusted with 6N NaOH solution to 5. The precipitated solid product was collected by filtration. The mother liquor layer was extracted with ethyl acetate (3 x 250 mL). The above solids were dissolved in the combined organic phases, washed with brine solution (1 x 250 mL), dried over anhydrous sodium sulfate, filtered and concentrated. Purification of the concentrate by short silica gel column chromatography afforded 7-chloro-5-methyl-1H-pyrazolo[4,3-b]pyridine (Compound Ie) as a light yellow solid (4.50 g, 26.8 mmol, 87% yield).GC/MS analysis: m/z = 167 (100%); LC/MS analysis: [M + H]+ = 168.

References

[1] Journal of Medicinal Chemistry, 2005, vol. 48, # 18, p. 5780 - 5793
[2] Patent: WO2006/44821, 2006, A1. Location in patent: Page/Page column 23-24

7-CHLORO-5-METHYL-1H-PYRAZOLO[4,3-B]PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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7-CHLORO-5-METHYL-1H-PYRAZOLO[4,3-B]PYRIDINE Suppliers

China 43 India 1 United Kingdom 2 United States 6 Global 52

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View Lastest Price from 7-CHLORO-5-METHYL-1H-PYRAZOLO[4,3-B]PYRIDINE manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 7-CHLORO-5-METHYL-1H-PYRAZOLO[4,3-B]PYRIDINE 94220-38-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-13

94220-38-9, 7-CHLORO-5-METHYL-1H-PYRAZOLO[4,3-B]PYRIDINERelated Search:

3-BROMO-7-CHLORO-5-METHYL-1H-PYRAZOLO[4,3-B]PYRIDINE 7-CHLORO-5-METHYL-1H-PYRAZOLO[4,3-B]PYRIDINE

7-CHLORO-5-METHYL-1H-PYRAZOLO[4,3-B]PYRIDINE

1H-Pyrazolo[4,3-b]pyridine, 7-chloro-5-Methyl-

94220-38-9