2,4-Dichloro-5-ethoxymethyl-pyrimidine
- Product Name
- 2,4-Dichloro-5-ethoxymethyl-pyrimidine
- CAS No.
- 7627-39-6
- Chemical Name
- 2,4-Dichloro-5-ethoxymethyl-pyrimidine
- Synonyms
- 2,4-Dichloro-5-(ethoxymethyl);2,4-Dichloro-5-ethoxymethyl-pyrimidine;Pyrimidine, 2,4-dichloro-5-(ethoxymethyl)-;2,4-dichloro-5-(ethoxymethyl)pyrimidine - [D87388]
- CBNumber
- CB02531793
- Molecular Formula
- C7H8Cl2N2O
- Formula Weight
- 207.06
- MOL File
- 7627-39-6.mol
2,4-Dichloro-5-ethoxymethyl-pyrimidine Property
- Boiling point:
- 274℃
- Density
- 1.331
- Flash point:
- 119℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -3.11±0.29(Predicted)
- Appearance
- Off-white to light brown Solid-Liquid Mixture
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H226Flammable liquid and vapour
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- HCH0295428
- Product name
- 2,4-DICHLORO-5-ETHOXYMETHYL-PYRIMIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.98
- Updated
- 2021/12/16
- Product number
- 61-5506
- Product name
- 2,4-dichloro-5-(ethoxymethyl)pyrimidine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $540
- Updated
- 2021/12/16
- Product number
- CM167613
- Product name
- 2,4-dichloro-5-(ethoxymethyl)pyrimidine
- Purity
- 97%
- Packaging
- 5g
- Price
- $542
- Updated
- 2021/12/16
- Product number
- 61-5506
- Product name
- 2,4-dichloro-5-(ethoxymethyl)pyrimidine
- Purity
- 95+%
- Packaging
- 10g
- Price
- $810
- Updated
- 2021/12/16
- Product number
- A169271
- Product name
- 2,4-Dichloro-5-(ethoxymethyl)pyrimidine
- Purity
- 97%
- Packaging
- 25g
- Price
- $828
- Updated
- 2021/12/16
2,4-Dichloro-5-ethoxymethyl-pyrimidine Chemical Properties,Usage,Production
Synthesis
89943-60-2
7627-39-6
Phosphoryl chloride (0.67 mL, 7.35 mmol) was slowly added to a suspension of 5-(ethoxymethyl)pyrimidine-2,4(1H,3H)-dione (0.5 g, 2.94 mmol) in toluene (1 mL) at 0 °C and stirred for 15 min. Subsequently, Hünig base (N,N-diisopropylethylamine, 0.77 mL, 4.41 mmol) was added dropwise to the reaction mixture at 0 °C. The reaction mixture was warmed to 120 °C and stirred for 1 hour. Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into a pre-cooled two-phase mixture of ethyl acetate and water (1:1, v/v) at 0°C for 45 minutes. Stirring was continued at the same temperature for 1.5 hours. The reaction mixture was extracted with ethyl acetate, the organic layers were combined, washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give the crude product INT-60 (0.40 g, 65% yield) as a brown liquid. The crude product was further purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (30:1 to 20:1). The product was characterized by 1H NMR (400 MHz, CDCl3): δ 8.67 (s, 1H), 4.56 (s, 2H), 3.66 (q, J=7.2 Hz, 2H), 1.30 (t, J=7.2 Hz, 3H).
References
[1] Patent: US2016/75720, 2016, A1. Location in patent: Paragraph 0331; 0333
2,4-Dichloro-5-ethoxymethyl-pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4-Dichloro-5-ethoxymethyl-pyrimidine manufacturers
- Product
- 2,4-Dichloro-5-(ethoxymethyl)pyrimidine 7627-39-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2020-05-15