Tert-butyl 3-bromo-6-chloropicolinate
- Product Name
- Tert-butyl 3-bromo-6-chloropicolinate
- CAS No.
- 1235036-15-3
- Chemical Name
- Tert-butyl 3-bromo-6-chloropicolinate
- Synonyms
- 3-Bromo-6-chloro-2-Boc-pyridine;Tert-butyl 3-bromo-6-chloropicolinate;Tert-butyl 3-bromo-6-chloropyridolinate;3-Bromo-6-chloropyridine Tert-Butyl formate;tert-butyl 3-bromo-6-chloropyridine-2-carboxylate;3-Bromo-6-Chloropyridinecarboxylic acid tert butyl ester;3-Bromo-6-chloro-pyridine-2-carboxylic acid tert-butyl ester;3-bromo-6-chloro-2-pyridinecarboxylic acid 1,1-dimethylethyl ester;2-Pyridinecarboxylic acid, 3-broMo-6-chloro-, 1,1-diMethylethyl ester;1,?1-?Dimethylethyl Ester 3-?Bromo-?6-?chloro-?2-?Pyridinecarboxylic Acid
- CBNumber
- CB02534956
- Molecular Formula
- C10H11BrClNO2
- Formula Weight
- 292.56
- MOL File
- 1235036-15-3.mol
Tert-butyl 3-bromo-6-chloropicolinate Property
- Boiling point:
- 334.3±37.0 °C(Predicted)
- Density
- 1.475±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -3.48±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C10H11BrClNO2/c1-10(2,3)15-9(14)8-6(11)4-5-7(12)13-8/h4-5H,1-3H3
- InChIKey
- JKGXLKXQUDHRLL-UHFFFAOYSA-N
- SMILES
- C1(C(OC(C)(C)C)=O)=NC(Cl)=CC=C1Br
Safety
- RIDADR
- UN2811
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
N-Bromosuccinimide Price
- Product number
- D480788
- Product name
- 1,1-DimethylethylEster3-Bromo-6-chloro-2-PyridinecarboxylicAcid
- Packaging
- 250mg
- Price
- $70
- Updated
- 2021/12/16
- Product number
- D480788
- Product name
- 1,1-DimethylethylEster3-Bromo-6-chloro-2-PyridinecarboxylicAcid
- Packaging
- 5g
- Price
- $715
- Updated
- 2021/12/16
- Product number
- 4487AA
- Product name
- tert-Butyl3-bromo-6-chloropicolinate
- Packaging
- 10g
- Price
- $725
- Updated
- 2021/12/16
- Product number
- 4H58-D-11
- Product name
- tert-Butyl 3-bromo-6-chloropyridine-2-carboxylate
- Purity
- 97.0%
- Packaging
- 1g
- Price
- $490
- Updated
- 2021/12/16
- Product number
- 4H58-D-11
- Product name
- tert-Butyl 3-bromo-6-chloropyridine-2-carboxylate
- Purity
- 97.0%
- Packaging
- 250mg
- Price
- $190
- Updated
- 2021/12/16
Tert-butyl 3-bromo-6-chloropicolinate Chemical Properties,Usage,Production
Uses
1,?1-?Dimethylethyl Ester 3-?Bromo-?6-?chloro-?2-?Pyridinecarboxylic Acid was used to study expeditious synthesis of isoquinolones and isocoumarins.
Synthesis
929000-66-8
75-65-0
1235036-15-3
GENERAL STEPS: Toluenesulfonyl chloride (7.7 g, 40.4 mmol) was slowly added to a solution of tert-butanol (33 mL) containing 3-bromo-6-chloro-2-pyridinecarboxylic acid (4 g, 17 mmol) and pyridine (9.2 mL, 114 mmol) at 0 °C. The reaction mixture was then stirred continuously at room temperature for 12 hours. Upon completion of the reaction, saturated sodium bicarbonate solution was added and extracted with ethyl acetate (3 times). The organic phases were combined, washed with saturated brine and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure to afford the target product tert-butyl 3-bromo-6-chloropyridine-2-carboxylate (121A) in quantitative yield. The resulting product can be used in subsequent reactions without further purification. Product characterization data: 1H NMR (300 MHz, CDCl3) δ 7.85 (d, 1H), 7.26 (d, 1H), 1.63 (s, 9H).
References
[1] Patent: WO2010/80503, 2010, A1. Location in patent: Page/Page column 232-233
[2] Patent: WO2010/80503, 2010, A1. Location in patent: Page/Page column 199
[3] Patent: US2013/96120, 2013, A1. Location in patent: Paragraph 0878
[4] Patent: US2013/96121, 2013, A1. Location in patent: Paragraph 1224
[5] Patent: WO2014/28381, 2014, A1. Location in patent: Page/Page column 112
Tert-butyl 3-bromo-6-chloropicolinate Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Tert-butyl 3-bromo-6-chloropicolinate manufacturers
- Product
- Tert-butyl 3-bromo-6-chloropicolinate 1235036-15-3
- Price
- US $70.00-1000.00/g
- Min. Order
- 5g
- Purity
- 99%
- Supply Ability
- 50
- Release date
- 2024-07-11
- Product
- Tert-butyl 3-bromo-6-chloropicolinate 1235036-15-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 200g
- Release date
- 2020-02-01