GYY 4137 Morpholine salt

Product Name: GYY 4137 Morpholine salt
CAS No.: 106740-09-4
Chemical Name: GYY 4137 Morpholine salt
Synonyms: ZYJ1122;GYY 4137;ZYJ 1122;ZYJ-1122.;GYY 4137, H2S donor;GYY 4137 MORPHOLINE SALT;GYY4137;GYY-4137;GYY 4137;Morpholine (4-methoxyphenyl)(morpholino)phosphinodithioate;4-Methoxyphenyl(morpholino)phosphinodithioate morpholinium salt;morpholin-4-ium (4-methoxyphenyl)(morpholino)phosphinodithioate
CBNumber: CB02538277
Molecular Formula: C15H25N2O3PS2
Formula Weight: 376.474361
MOL File: 106740-09-4.mol

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GYY 4137 Morpholine salt Property

Melting point:: 164-166℃
storage temp.: 2-8°C
solubility: DMF: 20 mg/ml; DMSO: 15 mg/ml; PBS (pH 7.2): 3 mg/ml
form: White solid.
color: White
InChI: InChI=1S/C11H16NO2PS2.C4H9NO/c1-13-10-2-4-11(5-3-10)15(16,17)12-6-8-14-9-7-12;1-3-6-4-2-5-1/h2-5H,6-9H2,1H3,(H,16,17);5H,1-4H2
InChIKey: YZMHNNLDUWRZFW-UHFFFAOYSA-N
SMILES: C1C(OC)=CC=C(P([S-])(N2CCOCC2)=S)C=1.C1C[N+]([H])([H])CCO1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0100
Product name: GYY4137 Dichloromethane complex
Purity: ≥98% (HPLC)
Packaging: 10 mg
Price: $83
Updated: 2025/07/31

Sigma-Aldrich

Product number: SML0100
Product name: GYY4137 Dichloromethane complex
Purity: ≥98% (HPLC)
Packaging: 50 mg
Price: $338
Updated: 2025/07/31

Cayman Chemical

Product number: 13345
Product name: GYY 4137
Purity: ≥95%
Packaging: 10mg
Price: $61
Updated: 2024/03/01

Cayman Chemical

Product number: 13345
Product name: GYY 4137
Purity: ≥95%
Packaging: 25mg
Price: $140
Updated: 2024/03/01

Cayman Chemical

Product number: 13345
Product name: GYY 4137
Purity: ≥95%
Packaging: 50mg
Price: $234
Updated: 2024/03/01

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GYY 4137 Morpholine salt Chemical Properties,Usage,Production

Description

Hydrogen sulfide (H₂S) is a gaseous mediator which, like nitric oxide (NO), has numerous profound actions in mammalian physiology. GYY 4137 is a water-soluble, slow-releasing hydrogen sulfide (H₂S) donor. When given intravenously, it demonstrates vasodilator and anti-hypertensive activity in rats, in either the acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models. Intravenous GYY 4137 also protects against endotoxic shock in rats, inhibiting tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production and reducing NF-κB activation, iNOS and cyclooxygenase-2 expression, and NO and prostaglandin E₂ generation.

Uses

Hydrogen sulfide (H2S) is a gaseous mediator which, like nitric oxide (NO), has numerous profound actions in mammalian physiology. GYY 4137 is a water-soluble, slow-releasing hydrogen sulfide (H2S) donor. When given intravenously, it demonstrates vasodilator and anti-hypertensive activity in rats, in either the acute (L-NAME-induced) or chronic (spontaneously hypertensive) hypertension models. Intravenous GYY 4137 also protects against endotoxic shock in rats, inhibiting tumor necrosis factor-α, interleukin (IL)-1β, and IL-6 production and reducing NF-κB activation, iNOS and cyclooxygenase-2 expression, and NO and prostaglandin E2 generation.[Cayman Chemical]

Uses

GYY 4137 is a slow releasing hydrogen sulfide donor.

in vivo

GYY4137 (100-300 mg/kg; i.p.; daily for 14 days) significantly reduces the tumor volume in both animal models, in a dose-dependent manner^[2].
In the complete Freund's adjuvant (CFA)-treated mouse, GYY4137 (50 mg/kg, i.p.) injected 1 hr prior to CFA increased knee joint swelling while an anti-inflammatory effect, as demonstrated by reduced synovial fluid myeloperoxidase (MPO) and N-acetyl-β-D-glucosaminidase (NAG) activity and decreased TNF-α, IL-1β, IL-6 and IL-8 concentration, was apparent when GYY4137 was injected 6 hrs after CFA^[3].
GYY4137 significantly inhibited tumor growth in the subcutaneous HepG2 xenograft model by inhibiting STAT3 activation and its target gene expression^[4].
GYY4137 prevents nitrative stress and α-synuclein nitration in an MPTP mouse model of parkinson’s disease^[5].

Animal Model:	Female, severe combined immunodeficiency (SCID) mice (bearing HL-60 or MV4-11 cells)^[2]
Dosage:	100, 200 and 300 mg/kg
Administration:	I.p.; daily for 14 days
Result:	Reduced tumor volume by 52.5% and 55.3% in HL-60 and MV4–11 injected animals.

IC 50

Stat-3

storage

+4°C

References

[1] LING LI. Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide.[J]. Circulation, 2008, 117 18: 2351-2360. DOI: 10.1161/circulationaha.107.753467
[2] LING LI . GYY4137, a novel hydrogen sulfide-releasing molecule, protects against endotoxic shock in the rat[J]. Free Radical Biology and Medicine, 2009, 47 1: Pages 103-113. DOI: 10.1016/j.freeradbiomed.2009.04.014
[3] PETER J ELLIOTT Wolf H B Thomas Matthias Zollner. Proteasome inhibition: a new anti-inflammatory strategy.[J]. Journal of Molecular Medicine-Jmm, 2003, 81 4: 235-245. DOI: 10.1007/s00109-003-0422-2

GYY 4137 Morpholine salt Preparation Products And Raw materials

Raw materials

Preparation Products

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GYY 4137 Morpholine salt Suppliers

China 106 Japan 1 United Kingdom 2 United States 14 Global 123

Shanghai Boyle Chemical Co., Ltd.

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Sigma-Aldrich

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View Lastest Price from GYY 4137 Morpholine salt manufacturers

Career Henan Chemical Co

Product: (4-methoxyphenyl)-morpholin-4-yl-sulfanylidene-sulfido-λ5-phosphane,morpholin-4-ium 106740-09-4
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

106740-09-4, GYY 4137 Morpholine saltRelated Search:

4-Methoxyphenyl(morpholino)phosphinodithioate morpholinium salt

GYY 4137 MORPHOLINE SALT

GYY 4137

(4-Methoxyphenyl)morpholino-phosphinodithioic acid compound with morpholine

(4-methoxyphenyl)-morpholin-4-yl-sulfanylidene-sulfido-λ5-phosphane,morpholin-4-ium

morpholin-4-ium (4-methoxyphenyl)(morpholino)phosphinodithioate

GYY4137;GYY-4137;GYY 4137

P-(4-Methoxyphenyl)-P-4-morpholinylphosphinodithioic acid morpholine salt

ZYJ 1122

ZYJ1122

ZYJ-1122.

Morpholine (4-methoxyphenyl)(morpholino)phosphinodithioate

GYY 4137, H2S donor

(4-Methoxyphenyl)morpholinylphosphinodithioic acid, morpholine salt

106740-09-4

C11H16NO2PS2C4H9NO

C4H9NOC11H16NO2PS2