ChemicalBook > CAS DataBase List > N-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide

N-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide

Product Name
N-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide
CAS No.
693288-97-0
Chemical Name
N-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide
Synonyms
CPPHA;CPPHA, 10 mM in DMSO;N-[4-Chloro-2-(phthalimidomethyl)phenyl]salicylamide;N-[4-chloro-2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]-2-hydroxybenzamide;N-[4-Chloro-2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]phenyl]-2-hydroxybenzamide;N-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide;Benzamide, N-[4-chloro-2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]phenyl]-2-hydroxy-
CBNumber
CB02538813
Molecular Formula
C22H15ClN2O4
Formula Weight
406.82
MOL File
693288-97-0.mol
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N-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide Property

Boiling point:
539.7±50.0 °C(Predicted)
Density 
1.505
storage temp. 
-20°C
solubility 
DMSO: >20mg/mL
form 
solid
pka
8.24±0.30(Predicted)
color 
Light yellow to yellow
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Safety

Hazard Codes 
N
Risk Statements 
50/53
Safety Statements 
60-61
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H410Very toxic to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
21275
Product name
CPPHA
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21275
Product name
CPPHA
Packaging
5mg
Price
$139
Updated
2024/03/01
Cayman Chemical
Product number
21275
Product name
CPPHA
Packaging
10mg
Price
$230
Updated
2024/03/01
Cayman Chemical
Product number
21275
Product name
CPPHA
Packaging
25mg
Price
$533
Updated
2024/03/01
Tocris
Product number
4787
Product name
CPPHA
Purity
≥98%(HPLC)
Packaging
10
Price
$203
Updated
2021/12/16
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N-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide Chemical Properties,Usage,Production

Description

CPPHA is a positive allosteric modulator of metabotropic glutamate receptor 5 (mGluR5) that potentiates human and rat mGluR5 activation by glutamate, 3,5-DHPG , and quisqualate (EC50s = 0.316-0.5 and 0.634-1.16 μM for human and rat mGluR5, respectively). It is selective for mGluR5 over other mGluRs but exhibits submicromolar activity at PDE6, δ- and κ-opioid receptors, and the ether-a-go-go related gene (ERG) potassium channel (Kis = 500, 352, 474, and 813 nM, respectively). CPPHA potentiates 3,5-DHPG-induced NMDA currents in CA1 pyramidal cells and the depolarization of rat subthalamic nucleus (STN) neurons.

N-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide Suppliers

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693288-97-0, N-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamideRelated Search:

N,N'-Ethylenebis(stearamide) Deionized water 2-Cyclopropyl-4-(4-fluorophenyl)-quinolyl-3-methanol

  • N-{4-chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide
  • N-[4-Chloro-2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]phenyl]-2-hydroxybenzamide
  • N-[4-Chloro-2-(phthalimidomethyl)phenyl]salicylamide
  • CPPHA
  • Benzamide, N-[4-chloro-2-[(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)methyl]phenyl]-2-hydroxy-
  • N-[4-chloro-2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]-2-hydroxybenzamide
  • CPPHA, 10 mM in DMSO
  • 693288-97-0