5-broMo-4-Methoxy-6-MethylpyriMidine
- Product Name
- 5-broMo-4-Methoxy-6-MethylpyriMidine
- CAS No.
- 4319-87-3
- Chemical Name
- 5-broMo-4-Methoxy-6-MethylpyriMidine
- Synonyms
- 5-broMo-4-Methoxy-6-MethylpyriMidine;Pyrimidine, 5-bromo-4-methoxy-6-methyl-
- CBNumber
- CB02546403
- Molecular Formula
- C6H7BrN2O
- Formula Weight
- 203.04
- MOL File
- 4319-87-3.mol
5-broMo-4-Methoxy-6-MethylpyriMidine Property
- Melting point:
- 79-80 °C
- Boiling point:
- 266.6±35.0 °C(Predicted)
- Density
- 1.534±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 2.22±0.26(Predicted)
- Appearance
- Off-white to light yellow Solid
- InChI
- InChI=1S/C6H7BrN2O/c1-4-5(7)6(10-2)9-3-8-4/h3H,1-2H3
- InChIKey
- YDPPNMNAHGZFDJ-UHFFFAOYSA-N
- SMILES
- C1=NC(C)=C(Br)C(OC)=N1
N-Bromosuccinimide Price
- Product number
- B682333
- Product name
- 5-Bromo-4-methoxy-6-methylpyrimidine
- Packaging
- 100mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- B682333
- Product name
- 5-Bromo-4-methoxy-6-methylpyrimidine
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- FB153944
- Product name
- 5-broMo-4-Methoxy-6-MethylpyriMidine
- Packaging
- 250mg
- Price
- $52.5
- Updated
- 2021/12/16
- Product number
- FB153944
- Product name
- 5-broMo-4-Methoxy-6-MethylpyriMidine
- Packaging
- 500mg
- Price
- $95
- Updated
- 2021/12/16
- Product number
- 6348AJ
- Product name
- 5-Bromo-4-methoxy-6-methylpyrimidine
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
5-broMo-4-Methoxy-6-MethylpyriMidine Chemical Properties,Usage,Production
Synthesis
124-41-4
3438-55-9
4319-87-3
1. 5-Bromo-4-chloro-6-methylpyrimidine (1.85 g, 8.92 mmol) was dissolved in 50 mL of methanol, and a methanolic solution of 25 wt% sodium methanolate (1.83 mL, 16.0 mmol) was added with stirring. 2. The reaction mixture was stirred for 1 hr at room temperature. 3. Upon completion of the reaction, the reaction was quenched by addition of a buffer solution of pH 7. 4. A large portion of the methanol was removed by reduced pressure distillation. Most of the methanol was removed by distillation under reduced pressure. 5. The remaining aqueous phase was diluted with water and extracted three times with ether. 6. The organic phases were combined, washed with brine, dried over anhydrous sodium sulfate, filtered, and concentrated to give 5-bromo-4-methoxy-6-methylpyrimidine (1.43 g, 79% yield). 7. The product was confirmed by 1H NMR (CDCl3, 400 MHz) and mass spectrometry (ES): 1H NMR δ 8.48 (s, 1H), 4.00 (s, 1H), 4.00 (s, 1H), and 4.00 (s). 1H), 4.00 (s, 3H), 2.54 (s, 3H); MS (ES) m/z 204 [M + 1]+.
References
[1] Patent: WO2005/105814, 2005, A1. Location in patent: Page/Page column 67-68
5-broMo-4-Methoxy-6-MethylpyriMidine Preparation Products And Raw materials
Raw materials
Preparation Products
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