1-Cyclobutyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole

Product Name: 1-Cyclobutyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
CAS No.: 1002309-48-9
Chemical Name: 1-Cyclobutyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Synonyms: 1-Cyclobutyl-1H-pyrazole-...;1-Cyclodecen-1-yl-boronic acid pinacol ester;1-Cyclobutyl-1H-pyrazole-4-boronic acid pinacol ester;1-Cyclobutyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl);1-Cyclobutyl-1H-pyrazole-4-boronic acid pinacol ester;1-cyclobutyl-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyra...;1-Cyclobutyl-1H-pyrazole-4-boronic acid pinacol ester - [SB8119];1-cyclobutyl-4-(tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole;1-cyclobutyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole;1-Cyclobutyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
CBNumber: CB02549686
Molecular Formula: C13H21BN2O2
Formula Weight: 248.13
MOL File: 1002309-48-9.mol

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1-Cyclobutyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Property

Boiling point:: 370.2±15.0 °C(Predicted)
Density: 1.14±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
pka: 3.33±0.12(Predicted)
form: solid
color: Off-white
InChIKey: OBCTWWFLJFCNPC-UHFFFAOYSA-N

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Safety

HS Code: 2933199090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: BML00012
Product name: 1-Cyclobutyl-1H-pyrazole-4-boronic acid pinacol ester
Purity: Aldrich
Packaging: 1g
Price: $1350
Updated: 2025/07/31

TRC

Product number: C989383
Product name: 1-Cyclobutyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Packaging: 100mg
Price: $75
Updated: 2021/12/16

Synthonix

Product number: SB8119
Product name: 1-Cyclobutyl-1H-pyrazole-4-boronic acid pinacol ester
Purity: 97.0%
Packaging: 1g
Price: $100
Updated: 2021/12/16

AK Scientific

Product number: X4879
Product name: 1-Cyclobutyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Packaging: 250mg
Price: $131
Updated: 2021/12/16

Synthonix

Product number: SB8119
Product name: 1-Cyclobutyl-1H-pyrazole-4-boronic acid pinacol ester
Purity: 97.0%
Packaging: 5g
Price: $290
Updated: 2021/12/16

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1-Cyclobutyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Chemical Properties,Usage,Production

Synthesis

269410-08-4

4399-47-7

1002309-48-9

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (300 mg, 1.55 mmol) was dissolved in N,N-dimethylformamide (DMF, 5 mL) at 0 °C and under argon protection. Sodium hydride (60% oil solution, 40.8 mg, 1.70 mmol) was added in batches, followed by stirring the reaction mixture for 20 min at room temperature. A DMF (1 mL) solution of bromocyclobutane (209 mg, 1.55 mmol) was added and stirring was continued for 2 hours at room temperature. Upon completion of the reaction, the reaction was quenched with saturated aqueous ammonium chloride solution and then extracted three times with ethyl acetate (EtOAc). The organic phases were combined, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. Purification by silica gel column chromatography afforded the target product N-cyclobutyl-pyrazole-4-boronic acid pinacol ester (20A, 40 mg, 5.21% yield). Mass spectrum (ESI): m/z 249.0 ([M+H]+).

References

[1] Patent: WO2017/160632, 2017, A1. Location in patent: Page/Page column 96
[2] Patent: WO2018/114786, 2018, A1. Location in patent: Page/Page column 152-153

1-Cyclobutyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Preparation Products And Raw materials

Raw materials

Preparation Products

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1-Cyclobutyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole Suppliers

China 89 Germany 1 India 2 United Kingdom 1 United States 10 Global 103

Pure Chemistry Scientific Inc.

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View Lastest Price from 1-Cyclobutyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Cyclobutyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1002309-48-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1-Cyclobutyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1002309-48-9
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

Career Henan Chemical Co

Product: 1-Cyclobutyl-4-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole 1002309-48-9
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%-100%
Supply Ability: 1
Release date: 2018-08-10

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