2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester
- Product Name
- 2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester
- CAS No.
- 6274-50-6
- Chemical Name
- 2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester
- Synonyms
- Methyl 2-(4-Methoxyphenyl)-2-Methylpropanoate;2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester;Benzeneacetic acid, 4-methoxy-α,α-dimethyl-, methyl ester
- CBNumber
- CB02550479
- Molecular Formula
- C12H16O3
- Formula Weight
- 208.25
- MOL File
- 6274-50-6.mol
2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester Property
- storage temp.
- Sealed in dry,Room Temperature
N-Bromosuccinimide Price
- Product number
- CHM0392882
- Product name
- METHYL-2-(4-METHOXYPHENYL)-2-METHYLPROPANOATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.73
- Updated
- 2021/12/16
- Product number
- 126898
- Product name
- Methyl2-(4-methoxyphenyl)-2-methylpropanoate
- Purity
- >95%
- Packaging
- 1g
- Price
- $694
- Updated
- 2021/12/16
- Product number
- 126898
- Product name
- Methyl2-(4-methoxyphenyl)-2-methylpropanoate
- Purity
- >95%
- Packaging
- 5g
- Price
- $2080
- Updated
- 2021/12/16
- Product number
- CC00-1136
- Product name
- 2-(4-Methoxy-phenyl)-2-methyl-propionic acid methyl ester
- Purity
- ＞97%
- Packaging
- 5G
- Price
- $875
- Updated
- 2021/12/16
- Product number
- 61-10080
- Product name
- Methyl2-(4-methoxyphenyl)-2-methylpropanoate
- Purity
- 95-98%
- Packaging
- 1g
- Price
- $1040
- Updated
- 2021/12/16
2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester Chemical Properties,Usage,Production
Synthesis
23786-14-3
74-88-4
6274-50-6
Methyl iodomethane (23.64 g, 166.5 mmol) was added slowly and dropwise to a tetrahydrofuran (THF, 100 mL) solution of methyl 2-(4-methoxyphenyl)acetate (10.0 g, 55.49 mmol) at -78 °C. Subsequently, potassium tert-butoxide (KOt-Bu, 18.68 g, 166.5 mmol) was added in batches over 30 min, keeping the reaction mixture stirred at -78 °C for 1 h. The reaction was then brought to room temperature and continued to be stirred for 1 h. The reaction was completed by the addition of potassium tert-butoxide (KOt-Bu, 18.68 g, 166.5 mmol). Upon completion of the reaction, the reaction was quenched by the addition of water (25 mL) and extracted with ethyl acetate (EtOAc, 2 x 250 mL). The organic layers were combined, dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure to give methyl 2-(4-methoxyphenyl)-2-methylpropionate (10.46 g, 91% yield).
References
[1] Patent: WO2013/19682, 2013, A1. Location in patent: Page/Page column 87
[2] Patent: WO2013/19635, 2013, A1. Location in patent: Page/Page column 55
[3] Helvetica Chimica Acta, 1971, vol. 54, p. 868 - 897
[4] Biomedical mass spectrometry, 1976, vol. 3, # 6, p. 316 - 328
[5] Patent: US5776951, 1998, A
2-(4-Methoxy-phenyl)-2-Methyl-propionicacidMethylester Preparation Products And Raw materials
Raw materials
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