ChemicalBook > CAS DataBase List > 7-Azaspiro[3.5]nonane-2,7-dicarboxylic acid, 7-(1,1-dimethylethyl) ester

7-Azaspiro[3.5]nonane-2,7-dicarboxylic acid, 7-(1,1-dimethylethyl) ester

Product Name
7-Azaspiro[3.5]nonane-2,7-dicarboxylic acid, 7-(1,1-dimethylethyl) ester
CAS No.
873924-12-0
Chemical Name
7-Azaspiro[3.5]nonane-2,7-dicarboxylic acid, 7-(1,1-dimethylethyl) ester
Synonyms
7-azaspiro[3.5]nonane-2-carboxylic acid;7-(tert-butoxycarbonyl)-7-azaspiro[3.5]nonane-2-carboxylic acid;7-Boc-7-azaspiro[3.5]nonane-2-carboxylic acid;7-(1,1-Dimethylethyl) 7-azaspiro[3.5]nonane-2,7-dicarboxylate;7-Azaspiro[3.5]nonane-2,7-dicarboxylic acid, 7-(1,1-dimethyl...;7-[(tert-butoxy)carbonyl]-7-azaspiro[3.5]nonane-2-carboxylic acidc;7-Azaspiro[3.5]nonane-2,7-dicarboxylic acid, 7-(1,1-dimethylethyl)ester;7-(tert-Butoxycarbonyl)-7-azaspiro[3.5]nonane-2-carboxylic acid - B6085;7-[(2-methylpropan-2-yl)oxycarbonyl]-7-azaspiro[3.5]nonane-2-carboxylic acid;7-(tert-butoxycarbonyl)-1H-pyrrolo[2,3-b]pyridinespiro[3.5]nonane-2-carboxylic acid
CBNumber
CB02552857
Molecular Formula
C14H23NO4
Formula Weight
269.34
MOL File
873924-12-0.mol
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7-Azaspiro[3.5]nonane-2,7-dicarboxylic acid, 7-(1,1-dimethylethyl) ester Property

Boiling point:
406.6±45.0 °C(Predicted)
Density 
1.18±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
4.69±0.20(Predicted)
Appearance
White to off-white Solid
InChI
InChI=1S/C14H23NO4/c1-13(2,3)19-12(18)15-6-4-14(5-7-15)8-10(9-14)11(16)17/h10H,4-9H2,1-3H3,(H,16,17)
InChIKey
ASNXCLBPISBIFU-UHFFFAOYSA-N
SMILES
C1C2(CCN(C(OC(C)(C)C)=O)CC2)CC1C(O)=O
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
B809405
Product name
7-(tert-Butoxycarbonyl)-7-azaspiro[3.5]nonane-2-carboxylicAcid
Packaging
2.5g
Price
$880
Updated
2021/12/16
Synthonix
Product number
B6085
Product name
7-(tert-Butoxycarbonyl)-7-azaspiro[3.5]nonane-2-carboxylicacid
Purity
97.0%
Packaging
1g
Price
$140
Updated
2021/12/16
SynQuest Laboratories
Product number
4H58-1-K4
Product name
7-Boc-7-azaspiro[3.5]nonane-2-carboxylic acid
Packaging
1g
Price
$225
Updated
2021/12/16
AK Scientific
Product number
Y4423
Product name
7-(tert-Butoxycarbonyl)-7-azaspiro[3.5]nonane-2-carboxylicacid
Packaging
1g
Price
$327
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM1050450
Product name
7-[(TERT-BUTOXY)CARBONYL]-7-AZASPIRO[3.5]NONANE-2-CARBOXYLIC ACID
Purity
95.00%
Packaging
5MG
Price
$456.64
Updated
2021/12/16
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7-Azaspiro[3.5]nonane-2,7-dicarboxylic acid, 7-(1,1-dimethylethyl) ester Chemical Properties,Usage,Production

Uses

7-(tert-Butoxycarbonyl)-7-azaspiro[3.5]nonane-2-carboxylic Acid is used as a reagent in the preparation of mineralocorticoid receptor agonists.

Synthesis

203662-66-2

873924-12-0

The general procedure for the synthesis of 7-(tert-butoxycarbonyl)-7-azaspiro[3.5]nonane-2-carboxylic acid using tert-butyl 2-cyano-7-azaspiro[3.5]nonane-7-carboxylate as a starting material was as follows: tert-butyl 2-cyano-7-azaspiro[3.5]nonane-7-carboxylate (1.5 g, 5.99 mmol) was dissolved in ethanol (40 mL) and water (40 mL) in a solvent mixture of ethanol (40 mL) and water (40 mL). Lithium hydroxide (880 mg, 21 mmol) was added to this solution and the reaction mixture was subsequently heated to reflux and held for 4 hours. After completion of the reaction, the mixture was cooled to room temperature. Ethanol was removed by rotary evaporator and the remaining aqueous phase was adjusted to pH 1-2 with 6N hydrochloric acid. next, the aqueous phase was extracted with ether. The organic layers were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated to give 7-(tert-butoxycarbonyl)-7-azaspiro[3.5]nonane-2-carboxylic acid (1.6 g, 99% yield) as a white solid. The product was characterized by 1H NMR (400 MHz, CDCl3): δ 3.34-3.41 (m, 2H), 3.27-3.34 (m, 2H), 3.10-3.21 (m, 1H), 2.12 (d, J = 8.9 Hz, 4H), 1.58-1.63 (m, 2H), 1.52-1.58 (m, 2H), 1.47 ( s, 9H). Mass spectral analysis showed m/z 214 ([MH - t-Bu]+), 292 ([MNa]+).

References

[1] Patent: US2010/113465, 2010, A1. Location in patent: Page/Page column 32

7-Azaspiro[3.5]nonane-2,7-dicarboxylic acid, 7-(1,1-dimethylethyl) ester Preparation Products And Raw materials

Raw materials

Preparation Products

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7-Azaspiro[3.5]nonane-2,7-dicarboxylic acid, 7-(1,1-dimethylethyl) ester Suppliers

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Nanjing Habo Medical Technology Co., Ltd.
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View Lastest Price from 7-Azaspiro[3.5]nonane-2,7-dicarboxylic acid, 7-(1,1-dimethylethyl) ester manufacturers

Career Henan Chemical Co
Product
7-Boc-7-azaspiro[3.5]nona... 873924-12-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2020-01-09

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