ChemicalBook > CAS DataBase List > 4-broMo-2-(difluoroMethoxy)pyridine

4-broMo-2-(difluoroMethoxy)pyridine

Product Name
4-broMo-2-(difluoroMethoxy)pyridine
CAS No.
832735-56-5
Chemical Name
4-broMo-2-(difluoroMethoxy)pyridine
Synonyms
4-broMo-2-(difluoroMethoxy)pyridine;Pyridine,4-bromo-2-(difluoromethoxy)-
CBNumber
CB02553708
Molecular Formula
C6H4BrF2NO
Formula Weight
224
MOL File
832735-56-5.mol
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4-broMo-2-(difluoroMethoxy)pyridine Property

Boiling point:
198.6±35.0 °C(Predicted)
Density 
1.670±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
0?+-.0.10(Predicted)
Appearance
Colorless to light yellow Liquid
InChI
InChI=1S/C6H4BrF2NO/c7-4-1-2-10-5(3-4)11-6(8)9/h1-3,6H
InChIKey
QKZHLBZNEBCOLM-UHFFFAOYSA-N
SMILES
C1(OC(F)F)=NC=CC(Br)=C1
CAS DataBase Reference
832735-56-5
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B292500
Product name
4-Bromo-2-(difluoromethoxy)pyridine
Packaging
50mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
PC201316
Product name
4-Bromo-2-(difluoromethoxy)pyridine
Purity
97%
Packaging
100mg
Price
$56
Updated
2021/12/16
AK Scientific
Product number
7622DA
Product name
4-Bromo-2-(difluoromethoxy)pyridine
Packaging
10g
Price
$1589
Updated
2021/12/16
Apolloscientific
Product number
PC201316
Product name
4-Bromo-2-(difluoromethoxy)pyridine
Purity
97%
Packaging
250mg
Price
$89
Updated
2021/12/16
AK Scientific
Product number
7622DA
Product name
4-Bromo-2-(difluoromethoxy)pyridine
Packaging
100mg
Price
$146
Updated
2021/12/16
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4-broMo-2-(difluoroMethoxy)pyridine Chemical Properties,Usage,Production

Synthesis

36953-37-4

1895-39-2

832735-56-5

General procedure for the synthesis of 4-bromo-2-difluoromethoxypyridine from 4-bromo-2-hydroxypyridine and sodium 2-chloro-2,2-difluoroacetate: Example 26i: 4-Bromo-2-hydroxypyridine (200 mg, 1.15 mmol) and sodium 2-chloro-2,2-difluoroacetate (210 mg, 1.38 mmol) were suspended in dry acetonitrile (8 mL). The reaction mixture was heated to reflux overnight and subsequently cooled to room temperature. The reaction mixture was extracted directly with pentane (3 × 5 mL). The organic phases were combined and concentrated to afford 219 mg (85% yield) of 4-bromo-2-difluoromethoxypyridine. Product characterization data were as follows: 1H-NMR (500 MHz, DMSO-d6) δ 8.18 (d, 1H), 7.70 (t, 1H), 7.56 (d, 1H), 7.50 (s, 1H); mass spectra (CI+) m/z 226, 224 [M + 1]+.

References

[1] Patent: US2010/125087, 2010, A1. Location in patent: Page/Page column 21
[2] Patent: WO2018/2760, 2018, A1. Location in patent: Page/Page column 100

4-broMo-2-(difluoroMethoxy)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-broMo-2-(difluoroMethoxy)pyridine Suppliers

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832735-56-5, 4-broMo-2-(difluoroMethoxy)pyridineRelated Search:


  • 4-broMo-2-(difluoroMethoxy)pyridine
  • Pyridine,4-bromo-2-(difluoromethoxy)-
  • 832735-56-5