4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine ethyl ester N-benzoylglycine salt

Product Name: 4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine ethyl ester N-benzoylglycine salt
CAS No.: 1137608-69-5
Chemical Name: 4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine ethyl ester N-benzoylglycine salt
Synonyms: CS-373;Telotristat,LX1606;Telotristat etiprate;Telotristatethylhippurate;Telotristat Etiprate （API）;Telotristat Etiprate, >=98%;Telotristat Ethyl Etiprate Salt;Telotristat Etiprate, 10 mM in DMSO;LX 1606 hippurate(Telotristat etiprate);Telotristat Etiprate (LX 1606 Hippurate)
CBNumber: CB02554280
Molecular Formula: C36H35ClF3N7O6
Formula Weight: 754.1546096
MOL File: 1137608-69-5.mol

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4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine ethyl ester N-benzoylglycine salt Property

storage temp.: Store at -20°C, protected from light
solubility: DMSO:59.33(Max Conc. mg/mL);78.67(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.44(Max Conc. mM)
DMF:50.0(Max Conc. mg/mL);66.3(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);6.63(Max Conc. mM)
form: Powder
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 25342
Product name: Telotristat Etiprate
Purity: ≥98%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 25342
Product name: Telotristat Etiprate
Purity: ≥98%
Packaging: 10mg
Price: $166
Updated: 2024/03/01

Cayman Chemical

Product number: 25342
Product name: Telotristat Etiprate
Purity: ≥98%
Packaging: 25mg
Price: $343
Updated: 2024/03/01

Cayman Chemical

Product number: 25342
Product name: Telotristat Etiprate
Purity: ≥98%
Packaging: 50mg
Price: $547
Updated: 2024/03/01

TRC

Product number: T017095
Product name: TelotristatEtiprate
Packaging: 5mg
Price: $165
Updated: 2021/12/16

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4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine ethyl ester N-benzoylglycine salt Chemical Properties,Usage,Production

Uses

Telotristat Etiprate is a solid orally bioavailable tryptophan hydroxylase (TPH) inhibitor.

in vivo

Telotristat ethyl (15, 50, 150, 300 mg/kg, po, qd) reduces serotonin content in the periphery, but not in the brain of the mice. Telotristat ethyl (200 mg/kg po, qd) prevents the increase in blood neutrophil counts that is observed after TNBS challenge, provides significant protection in a mouse model of inflammatory bowel disease. Telotristat ethyl (200 mg/kg po, qd) protects the mouse IBD model confirmed by histopathology evaluation^[1].
Telotristat ethyl (15, 50, 150, 300 mg/kg) depletes 5-HT from the jejunum but not the brain. But Telotristat ethyl (200 mg/kg, p.o.) does not deplete enteric neuronal serotonin (5-HT), or alter constitutive gastrointestinal motility in mice. Telotristat ethyl (200 mg/kg) alleviates the severity of trinitrobenzene sulfonic acid (TNBS)-induced colitis^[2].

4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine ethyl ester N-benzoylglycine salt Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine ethyl ester N-benzoylglycine salt Suppliers

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View Lastest Price from 4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine ethyl ester N-benzoylglycine salt manufacturers

Career Henan Chemical Co

Product: 4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine ethyl ester N-benzoylglycine salt 1137608-69-5
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 200g
Release date: 2020-02-01

Career Henan Chemical Co

Product: 4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine ethyl ester N-benzoylglycine salt 1137608-69-5
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: ask
Release date: 2018-12-23

1137608-69-5, 4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine ethyl ester N-benzoylglycine saltRelated Search:

Aspartate aminotransferase IL21R oligosaccharins

Telotristat Etiprate, >=98%

(S)-ethyl 2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate hippurate

LX 1032 hippurate / Telotristat etiprate

Telotristat Etiprate , LP778902 hippurate salt

2-Benzamidoacetic acid, ((S)-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phen

4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine ethyl ester N-benzoylglycine salt

Telotristat etiprate

Telotristat Etiprate (LX 1606 Hippurate)

LX 1606 hippurate(Telotristat etiprate)

CS-373

TELOTRISTAT ETIPRATE; LX 1606 HIPPURATE; LX-1606 HIPPURATE

Telotristat,LX1606

ethyl (S)-2-amino-3-(4-(2-amino-6-((R)-1-(4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate benzoylglycinate

Telotristat Etiprate （API）

L-Phenylalanine, 4-[2-amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-, ethyl ester, compd. with N-benzoylglycine (1:1)

LX1606 HIPPURATE;TELOTRISTAT ETIPRATE;LX-1606 HIPPURATE

Telotristat Ethyl Etiprate Salt

Telotristatethylhippurate

4-[2-Amino-6-[(1R)-1-[4-chloro-2-(3-methyl-1H-pyrazol-1-yl)phenyl]-2,2,2-trifluoroethoxy]-4-pyrimidinyl]-L-phenylalanine ethyl ester N-benzoylglycine salt USP/EP/BP

Telotristat Etiprate, 10 mM in DMSO

1137608-69-5

11137608-69-5

C27H26ClF3N6O3C9H9NO3

C36H35ClF3N7O6

Inhibitors