5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid

Product Name: 5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid
CAS No.: 91182-60-4
Chemical Name: 5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid
Synonyms: EOS-60371;5-(4-Br-Ph)-3-Me-isoxazole-4-carboxylic acid;5-(p-Bromophenyl)-3-methyl-4-isoxazolecarboxylic acid;5-(4-Bromophenyl)-3-methyl-4-isoxazolecarboxylic acid;4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-;5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid;5-(4-bromophenyl)-3-methyl-1,2-oxazole-4-carboxylic acid
CBNumber: CB02557089
Molecular Formula: C11H8BrNO3
Formula Weight: 282.09
MOL File: 91182-60-4.mol

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5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid Property

Boiling point:: 409℃
Density: 1.605
Flash point:: 201℃
storage temp.: Sealed in dry,Room Temperature
Appearance: White to off-white Solid

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Safety

HazardClass: IRRITANT
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B807823
Product name: 5-(4-Bromophenyl)-3-methylisoxazole-4-carboxylicAcid
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B807823
Product name: 5-(4-Bromophenyl)-3-methylisoxazole-4-carboxylicAcid
Packaging: 500mg
Price: $70
Updated: 2021/12/16

TRC

Product number: B807823
Product name: 5-(4-Bromophenyl)-3-methylisoxazole-4-carboxylicAcid
Packaging: 1g
Price: $105
Updated: 2021/12/16

AK Scientific

Product number: Y6488
Product name: 5-(4-Bromophenyl)-3-methylisoxazole-4-carboxylicacid
Packaging: 250mg
Price: $75
Updated: 2021/12/16

ChemScene

Product number: CS-M1999
Product name: 4-Isoxazolecarboxylicacid,5-(4-bromophenyl)-3-methyl-
Purity: 96.37%
Packaging: 1g
Price: $88
Updated: 2021/12/16

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5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid Chemical Properties,Usage,Production

Synthesis

917388-58-0

91182-60-4

General procedure for the synthesis of 5-(4-bromophenyl)-3-methyl-isoxazole-4-carboxylic acid from ethyl 5-(4-bromophenyl)-3-methyl-isoxazole-4-carboxylate: to a stirred THF/H2O (79/35 ml) solution of ethyl 5-(4-bromophenyl)-3-methyl-isoxazole-4-carboxylate (3.2 g, 0.010 mol) was added lithium hydroxide ( 2.4 g, 0.010 mol). The reaction mixture was stirred at room temperature overnight and the THF solvent was removed from the reaction mixture under reduced pressure. The residue was diluted with water and washed with ether (2 x 50 ml). Subsequently, the aqueous phase was acidified to pH 4 with saturated aqueous NaHCO3 and extracted with ethyl acetate (2 x 75 ml). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the pure product 5-(4-bromophenyl)-3-methyl-isoxazole-4-carboxylic acid 2.8 g (96% yield). Product characterization data: 1H NMR (DMSO-d6): δ 2.52 (3H, s), 7.37 (2H, dd), 7.91 (2H, dd), 12.42 (1H, br s). 13C NMR (DMSO-d6) δ 12.0,110.0,126.6,127.2,131.7,132.5,162.4. 164.4,172.7. mass spectrum (MH+) = 282.

References

[1] Patent: US2006/287287, 2006, A1. Location in patent: Page/Page column 31-32

5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid Suppliers

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View Lastest Price from 5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid manufacturers

Career Henan Chemical Co

Product: 5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid 91182-60-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-12-18

91182-60-4, 5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acidRelated Search:

5-(4-Bromo-phenyl)-3-methyl-isoxazole-4-carboxylic acid

EOS-60371

4-Isoxazolecarboxylic acid, 5-(4-broMophenyl)-3-Methyl-

5-(4-Bromophenyl)-3-methyl-4-isoxazolecarboxylic acid

5-(p-Bromophenyl)-3-methyl-4-isoxazolecarboxylic acid

5-(4-bromophenyl)-3-methyl-1,2-oxazole-4-carboxylic acid

5-(4-Br-Ph)-3-Me-isoxazole-4-carboxylic acid

91182-60-4