2-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4-ol

Product Name: 2-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4-ol
CAS No.: 34170-21-3
Chemical Name: 2-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4-ol
Synonyms: 2-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4-ol;5,6,7,8-Tetrahydro-2-(methylthio)-4-quinazolinone;2-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4(1H)-one;2-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4(3H)-one;5,6,7,8-Tetrahydro-2-(methylthio)-4(1H)-quinazolinone;2-Methylsulfanyl-5,6,7,8-hexahydro-3H-quinazolin-4-one;2-methylsulfanyl-5,6,7,8-tetrahydro-3H-quinazolin-4-one;4(3H)-Quinazolinone, 5,6,7,8-tetrahydro-2-(methylthio)-;2-(Methylsulfanyl)-3,4,5,6,7,8-hexahydroquinazolin-4- one
CBNumber: CB02561136
Molecular Formula: C9H12N2OS
Formula Weight: 196.27
MOL File: 34170-21-3.mol

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2-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4-ol Property

Melting point:: 220-222℃
Boiling point:: 340.7±25.0 °C(Predicted)
Density: 1.39
storage temp.: Sealed in dry,Room Temperature
pka: -0.20±0.20(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M726103
Product name: 2-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4(3H)-one
Packaging: 50mg
Price: $110
Updated: 2021/12/16

AK Scientific

Product number: Z4619
Product name: 2-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4(3H)-one
Packaging: 250mg
Price: $182
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0128689
Product name: 2-(METHYLSULFANYL)-5,6,7,8-TETRAHYDRO-4-QUINAZOLINOL
Purity: 95.00%
Packaging: 1MG
Price: $658.53
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0128689
Product name: 2-(METHYLSULFANYL)-5,6,7,8-TETRAHYDRO-4-QUINAZOLINOL
Purity: 95.00%
Packaging: 10MG
Price: $692.49
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0128689
Product name: 2-(METHYLSULFANYL)-5,6,7,8-TETRAHYDRO-4-QUINAZOLINOL
Purity: 95.00%
Packaging: 5MG
Price: $697.51
Updated: 2021/12/16

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2-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4-ol Chemical Properties,Usage,Production

Synthesis

77766-03-1

34170-21-3

2-Methylthioalkyl-5,6,7,8-tetrahydroquinazolin-4-ylamine (5.09 g, 23.145 mmol) was used as a starting material and was mixed with 3-methyl-1-nitrosooxybutane (11.6 mL, 86.79 mmol) and trifluoroacetic acid (23.2 mL, 300.89 mmol) in chloroform (300 mL) to form a light yellow solution. The reaction system was heated to 60 °C and stirred continuously for 2 hours. Upon completion of the reaction, the reaction mixture was diluted with dichloromethane and subsequently extracted with 10% K2CO3 solution. After separation of the aqueous phase, the mixture was back-extracted once with dichloromethane, saturated with NaCl and then extracted with ethyl acetate. All organic phases were combined, dried with Na2SO4, filtered and the solvent evaporated. The resulting crude product was adsorbed onto an adsorbent and purified by chromatography on a Combiflash Companion XL system equipped with a SI50 silica gel column. The product grades were collected, and after evaporation of the solvent, the crystalline residue was ground in ether, filtered by pumping and dried under vacuum to yield 2.0 g of 5,6,7,8-tetrahydro-2-(methylthio)-4-quinazolinone in 57% yield as a crystal form.

References

[1] Chemical & Pharmaceutical Bulletin, 1981, vol. 29, # 4, p. 948 - 954
[2] Patent: WO2013/117288, 2013, A1. Location in patent: Page/Page column 53-54

2-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4-ol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4-ol manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 2-(Methylthio)-5,6,7,8-tetrahydroquinazolin-4-ol 34170-21-3
Price: US $1.00/Kg
Min. Order: 1Kg
Purity: 98%
Supply Ability: 20T
Release date: 2024-08-07

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34170-21-3