1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-
- Product Name
- 1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-
- CAS No.
- 918516-27-5
- Chemical Name
- 1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-
- Synonyms
- Vemurafenib Impurity 1;5-(4-Chlorophenyl)-7-azaindole;1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-;1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)-###918516-27-5
- CBNumber
- CB02562991
- Molecular Formula
- C13H9ClN2
- Formula Weight
- 228.68
- MOL File
- 918516-27-5.mol
1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)- Property
- Density
- 1.326±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 13.51±0.40(Predicted)
- Appearance
- Off-white to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C385988
- Product name
- 5-(4-Chlorophenyl)-1h-pyrrolo[2,3-B]pyridine
- Packaging
- 50mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- C385988
- Product name
- 5-(4-Chlorophenyl)-1h-pyrrolo[2,3-B]pyridine
- Packaging
- 100mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- 8914DN
- Product name
- 5-(4-Chlorophenyl)-1H-pyrrolo[2,3-B]pyridine
- Packaging
- 5g
- Price
- $386
- Updated
- 2021/12/16
- Product number
- CM149295
- Product name
- 5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
- Purity
- 95%
- Packaging
- 5g
- Price
- $421
- Updated
- 2021/12/16
- Product number
- A159015
- Product name
- 5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridine
- Purity
- 97%
- Packaging
- 10g
- Price
- $442
- Updated
- 2021/12/16
1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)- Chemical Properties,Usage,Production
Synthesis
1679-18-1
183208-35-7
918516-27-5
General method: Steps: 5-bromo-7-azaindole (2 g, 10.2 mmol, 1.0 eq.), K2CO3 (2.8 g, 20.3 mmol, 2 eq.) and 4-chlorobenzeneboronic acid (1.8 g, 11.2 mmol, 1.1 eq.) were suspended in a solvent mixture of DME/H2O (30 ml, 4:1) and degassed with argon. Pd(PPh3)4 (587 mg, 508 μmol, 0.05 eq.) was added and the reaction mixture was heated to reflux until the feedstock was completely consumed. Upon completion of the reaction, the solution was allowed to filter through a diatomaceous earth pad, diluted with EtOAc and washed with water. The organic layers were combined, dried with Na2SO4 and the solvent evaporated under reduced pressure. The crude product was purified by fast chromatography (SiO2, hexane/EtOAc 6:4). Yield: 2.23 g, 9.4 mmol, 92% (white solid).TLC: petroleum ether/EtOAc 1:1.1H NMR (DMSO-d6, 200 MHz, ppm): δ 11.76 (s, 1H), 8.51 (d, J = 2.1 Hz, 1H), 8.20 (d, J = 1.9 Hz, 1H), 7.72 (d, J = 8.5 Hz, 2H), 7.57-7.43 (m, 3H), 6.50 (dd, J=3.2,1.7 Hz, 1H).13C NMR (DMSO-d6, 50 MHz, ppm): δ148.2, 141.4, 138.0, 131.7, 128.9, 128.6, 127.1, 126.9, 126.1 , 117.7, 100.2.
References
[1] Patent: WO2018/134254, 2018, A1. Location in patent: Page/Page column 35; 36; 79; 80
[2] Tetrahedron Letters, 2012, vol. 53, # 32, p. 4161 - 4165
[3] Patent: WO2015/75749, 2015, A1. Location in patent: Page/Page column 43; 44
[4] Journal of Medicinal Chemistry, 2017, vol. 60, # 23, p. 9470 - 9489
1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)- manufacturers
- Product
- 1H-Pyrrolo[2,3-b]pyridine, 5-(4-chlorophenyl)- 918516-27-5
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- JD 498
- Release date
- 2019-09-01