ChemicalBook > CAS DataBase List > 1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol

1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol

Product Name: 1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol
CAS No.: 1256546-72-1
Chemical Name: 1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol
Synonyms: 106435;1,4-Dioxaspiro[4,5]decane-8,8-diMethanol;1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol;[8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl]methanol;[8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl]methanol - [H18075]
CBNumber: CB02563468
Molecular Formula: C10H18O4
Formula Weight: 202.25
MOL File: 1256546-72-1.mol

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1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol Property

Boiling point:: 347.2±17.0 °C(Predicted)
Density: 1.22±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: 14.69±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C10H18O4/c11-7-9(8-12)1-3-10(4-2-9)13-5-6-14-10/h11-12H,1-8H2
InChIKey: SXKPJJHMUALAKH-UHFFFAOYSA-N
SMILES: O1C2(CCC(CO)(CO)CC2)OCC1

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Safety

HS Code: 2932990090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: CHM0386807
Product name: 1,4-DIOXASPIRO[4.5]DECANE-8,8-DIYLDIMETHANOL
Purity: 95.00%
Packaging: 5MG
Price: $503.38
Updated: 2021/12/16

Matrix Scientific

Product number: 132069
Product name: 1,4-Dioxaspiro[4.5]decane-8,8-diyldimethanol
Purity: 95%
Packaging: 500mg
Price: $540
Updated: 2021/12/16

Matrix Scientific

Product number: 132069
Product name: 1,4-Dioxaspiro[4.5]decane-8,8-diyldimethanol
Purity: 95%
Packaging: 1g
Price: $810
Updated: 2021/12/16

AK Scientific

Product number: 4815AA
Product name: 1,4-Dioxaspiro[4.5]decane-8,8-diyldimethanol
Packaging: 1g
Price: $1143
Updated: 2021/12/16

SynQuest Laboratories

Product number: 2H10-1-98
Product name: 1,4-Dioxaspiro[4.5]decane-8,8-dimethanol
Packaging: 1g
Price: $1360
Updated: 2021/12/16

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1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol Chemical Properties,Usage,Production

Synthesis

1256546-71-0

1256546-72-1

The synthesis of 1,4-dioxaspiro[4.5]decane-8,8-dicarboxylic acid diethyl ester (Intermediate 3, 128.7 g, 450 mmol) was carried out as a raw material for the synthesis of 1,4-dioxaspiro[4.5]decane-8,8-dimethanol (Intermediate 4). The procedure was as follows: a THF solution (900 mL, 900 mmol) of 1 M lithium aluminum hydride was added to a 3-necked 1 L round-bottomed flask equipped with a thermometer, a dropping funnel, and a nitrogen inlet under nitrogen protection and cooled using a dry ice/acetone bath until the internal temperature was maintained at 10-15 °C. The THF solution (75 mL) of intermediate 3 was added slowly and dropwise over a period of 1 hr. The reaction mixture was gradually brought back to room temperature in a cooling bath and stirred overnight. Subsequently, the mixture was cooled to -5°C and quenched by the slow addition of water (40 mL) under vigorous stirring for 1.5 h. The reaction was carried out during 1.5 h, during which the internal temperature was strictly controlled not to exceed 30°C. Next, 15% NaOH solution (40 mL) and water (40 mL) were added dropwise. The precipitate obtained was filtered through diatomaceous earth and washed with THF (300 mL). The filtrate was concentrated to dryness in vacuum to afford 1,4-dioxaspiro[4.5]decane-8,8-dimethanol (63.3 g) as a white solid. The white filter cake was further extracted with 10% MeOH/CH2Cl2 (2 x 500 mL) to obtain additional product (15.6 g). The total yield was 78.9 g (0.39 mol, 87% yield). The product was characterized by LCMS and NMR: LCMS m/z 203 (M+H), 225 (M+Na); 1H NMR (500MHz, CD3OD) δ ppm 1.49-1.55 (4H, m, 3,5-CH2), 1.59-1.66 (4H, m, 2,6-CH2), 3.49 (4H, s, 9,10-OCH2 ), 3.94 (4H, s, 7,8-OCH2); 13C NMR (126MHz, CD3OD) δ ppm 26.7 (3,5-CH2), 30.3 (2,6-CH2), 38.3 (4-C), 64.2 (7,8-OCH2), 65.4 (9,10-OCH2), 109.2 (1-OCO).

References

[1] Patent: WO2012/78834, 2012, A1. Location in patent: Page/Page column 62-63
[2] Patent: EP3281942, 2018, A1. Location in patent: Paragraph 0156; 0157
[3] ACS Medicinal Chemistry Letters, 2014, vol. 5, # 5, p. 609 - 614
[4] Patent: EP2881394, 2015, A1. Location in patent: Paragraph 0364
[5] Patent: WO2014/153226, 2014, A1. Location in patent: Paragraph 00333

1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol manufacturers

Career Henan Chemical Co

Product: 1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol 1256546-72-1
Price: US $6.60/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg-1000kg
Release date: 2019-12-25

1256546-72-1, 1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanolRelated Search:

1,4-dioxaspiro[4.5]decane-8,8-diyldiMethanol

1,4-Dioxaspiro[4,5]decane-8,8-diMethanol

106435

[8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl]methanol

[8-(hydroxymethyl)-1,4-dioxaspiro[4.5]decan-8-yl]methanol - [H18075]

1256546-72-1