Methyl 3-chloro-1H-pyrrole-2-carboxylate
- Product Name
- Methyl 3-chloro-1H-pyrrole-2-carboxylate
- CAS No.
- 226410-00-0
- Chemical Name
- Methyl 3-chloro-1H-pyrrole-2-carboxylate
- Synonyms
- Methyl 3-chloro-1H-pyrrol...;Methyl 3-Chloropyrrole-2-carboxylate;Methyl 3-chloro-1H-pyrrole-2-carboxylate;1H-Pyrrole-2-carboxylic acid, 3-chloro-, methyl ester
- CBNumber
- CB02582654
- Molecular Formula
- C6H6ClNO2
- Formula Weight
- 159.57
- MOL File
- 226410-00-0.mol
Methyl 3-chloro-1H-pyrrole-2-carboxylate Property
- Boiling point:
- 270.6±20.0 °C(Predicted)
- Density
- 1.356±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 13.58±0.50(Predicted)
- Appearance
- Light yellow to brown Solid
- InChI
- InChI=1S/C6H6ClNO2/c1-10-6(9)5-4(7)2-3-8-5/h2-3,8H,1H3
- InChIKey
- YFKTWBUEAJFGRQ-UHFFFAOYSA-N
- SMILES
- N1C=CC(Cl)=C1C(OC)=O
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- M340453
- Product name
- Methyl3-Chloro-1H-pyrrole-2-carboxylate
- Packaging
- 50mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- Z4450
- Product name
- Methyl3-chloro-1H-pyrrole-2-carboxylateHCl.tech.
- Packaging
- 5g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- OR929899
- Product name
- Methyl3-chloro-1H-pyrrole-2-carboxylate
- Purity
- 98%
- Packaging
- 1g
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 4H58-5-A8
- Product name
- Methyl 3-chloro-1H-pyrrole-2-carboxylate
- Packaging
- 1g
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 4H58-5-A8
- Product name
- Methyl 3-chloro-1H-pyrrole-2-carboxylate
- Packaging
- 5G
- Price
- $450
- Updated
- 2021/12/16
Methyl 3-chloro-1H-pyrrole-2-carboxylate Chemical Properties,Usage,Production
Synthesis
872-32-2
226410-00-0
General procedure for the synthesis of methyl 3-chloropyrrole-2-carboxylate from 2-methylpyrroline: 5-methyl-3,4-dihydro-2H-pyrrole (1.00 g, 12.0 mmol) was dissolved in carbon tetrachloride. To this solution was added N-chlorosuccinimide (NCS, 12.85 g, 96 mmol) and the reaction mixture was heated to 85 °C and stirred overnight. After completion of the reaction, the mixture was cooled to 0 °C, the precipitate was collected by filtration and the solvent was removed by evaporation. The residue was dissolved in methanol and sodium methanolate (3.90 g, 72.2 mmol) was added. The resulting suspension was heated to reflux and stirred for 3 hours. Upon completion of the reaction, the methanol was removed by evaporation and the residue was suspended in ether. The solids were removed by filtration and the ether was removed by evaporation. The residue was dissolved in dichloromethane and 2M hydrochloric acid was added. The two-phase solution was stirred until the ingredients were completely consumed. The organic and aqueous phases were separated, the organic phase was dried with anhydrous magnesium sulfate and concentrated by evaporation to give an orange oil. The crude product was purified by silica gel column chromatography using 40 g silica gel with ethyl acetate and hexane as eluents to afford methyl 3-chloropyrrole-2-carboxylate as an orange solid (0.2958 g, 1.854 mmol, 15.41% yield).1H NMR (400 MHz, CDCl3): δ 9.54 (br.s., 1H), 6.80 (s, 1H) , 6.17 (s, 1H), 3.83 (s, 3H).MS: m/z 160.0 (M + 1).
References
[1] Patent: WO2008/154271, 2008, A1. Location in patent: Page/Page column 143
[2] Journal of Medicinal Chemistry, 2010, vol. 53, # 22, p. 7967 - 7978
[3] Patent: EP2612848, 2013, A1
[4] Patent: US2013/267521, 2013, A1
[5] Patent: WO2014/15675, 2014, A1
Methyl 3-chloro-1H-pyrrole-2-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Methyl 3-chloro-1H-pyrrole-2-carboxylate Suppliers
- Tel
- 0519-86058959
- Fax
- 0519-85286229
- 2850886771@qq.com
- Country
- China
- ProdList
- 222
- Advantage
- 50
- Tel
- 13262848185
- 20840032@qq.com
- Country
- China
- ProdList
- 161
- Advantage
- 58
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- 18993966060
- Fax
- 0943-8288977
- sales@techbiochem.com
- Country
- China
- ProdList
- 806
- Advantage
- 61
- Tel
- +86-18068513926
- Fax
- 0086-519-85153711
- Country
- China
- ProdList
- 1277
- Advantage
- 55
- Tel
- 0551-66399836 18955197623
- sales@enlipharma.com
- Country
- China
- ProdList
- 1876
- Advantage
- 55
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 39966
- Advantage
- 60
- Tel
- 027-87465837 19945049750
- Fax
- 027-8777-2287
- sales@finetechnology-ind.com
- Country
- China
- ProdList
- 9637
- Advantage
- 58
View Lastest Price from Methyl 3-chloro-1H-pyrrole-2-carboxylate manufacturers
- Product
- Methyl 3-Chloropyrrole-2-carboxylate 226410-00-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.0001kg
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-05-09
- Product
- Methyl 3-chloro-1H-pyrrole-2-carboxylate 226410-00-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- Methyl 3-chloro-1H-pyrrole-2-carboxylate 226410-00-0
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09