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AvibactaM

Product Name
AvibactaM
CAS No.
1192500-31-4
Chemical Name
AvibactaM
Synonyms
EOS-60408;AvibactaM;Avibactam acid;NXL-104 free acid;Avibactam free acid;Avibactam Impurity 37;(E)-7-fluoro-3-methylhept-4-en-2-one;AVIBACTAM FREE ACID (NXL-104 FREE ACID);(2S,5R)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-c...;(2S,5R)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carbox amide
CBNumber
CB02582836
Molecular Formula
C7H11N3O6S
Formula Weight
265.24
MOL File
1192500-31-4.mol
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AvibactaM Property

Density 
1.85
storage temp. 
Store at -20°C
solubility 
DMSO
form 
Powder
pka
-4.59±0.18(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0013803
Product name
AVIBACTAM
Purity
95.00%
Packaging
5MG
Price
$499.8
Updated
2021/12/16
ApexBio Technology
Product number
A3205
Product name
Avibactam
Packaging
5mg
Price
$537
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0013803
Product name
AVIBACTAM
Purity
95.00%
Packaging
100MG
Price
$995
Updated
2021/12/16
Crysdot
Product number
CD31004353
Product name
Avibactamfreeacid
Purity
98+%
Packaging
5mg
Price
$168
Updated
2021/12/16
Chemenu
Product number
CM202052
Product name
(1R,2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-ylhydrogensulfate
Purity
98%
Packaging
10mg
Price
$295
Updated
2021/12/16
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AvibactaM Chemical Properties,Usage,Production

Uses

Avibactam Butylammonium Salt is a novel β-lactamase inhibitor with a non-lactam structural scaffold. Avibactam irreversibly inhibits lactamase from Mycobacterium tuberculosis.

Definition

ChEBI: A member of the class of azabicycloalkanes that is (2S,5R)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide in which the amino hydrogen at position 6 is replaced by a sulfooxy group. Used (in the form of its sodium salt) n combination with ceftazidime pentahydrate for the treatment of complicated urinary tract infections including pyelonephritis.

Enzyme inhibitor

This non-β-lactam inhibitor of β-lactamase (FW = 261.27 g/mol; CAS 1192500-31-4), also known as NLX104 and AVE1330A, shows a spectrum of action against Classes A and C β-lactamase as well as selected Class D β-lactamase, enzymes that often confer resistance to β-lactam antibiotics. By forming a high-affinity complex with its target enzymes, avibactam enhances the antibacterial activity of certain β-lactam drugs, such as ceftaroline. With over 1000 known β-lactamase, the action of avibactam is apt to depend on the invidual active-site interactions. Mode of Action: Acylation and deacylation rates have been measured for the clinically important enzymes CTX-M-15, KPC-2, E. cloacae AmpC, P. aeruginosa AmpC, OXA-10, and OXA-48. The efficiency of acylation (kon/Ki) varies across the enzyme spectrum, from 1.1 x 101 M–1 s –1 for OXA-10 to 1.0 x 105 M–1 s –1 for CTX-M-15. Inhibition of OXA-10 was shown to follow a reversible covalent mechanism (see below), and the acylated OXA-10 displayed the longest residence time for deacylation, with a half-life of greater than 5 days. The inhibited enzyme forms are stable to hydrolysis for all enzymes with the exception of KPC-2, which displays slow hydrolytic route that involved fragmentation of the acyl-avibactam complex. In the case of TEM-1 lactamase, avibactam slowly covalently acylates its target, and the acylated enzyme subsequently undergoes slow deacylation (koff = 0.045 min?1 ) regenerating avibactam intact. Use as a Combined Drug: Combination of avibactim with extended-spectrum cephalosporins or aztreonam shows promise in inhibiting Klebsiella pneumoniae (KP) isolates harboring carbapenemases, or KPCs. Given abundant experience with ceftazidime and the significant improvement avibactam provides against contemporary β-lactamase-producing Gram-negative pathogens, this combination will likely play a role in the treatment of complicated urinary tract infections (as monotherapy) and complicated intra-abdominal infections (in combination with metronidazole) caused (or suspected to be caused) by otherwise resistant pathogens, such as extended spectrum β-lactamase-, AmpC-, or Klebsiella pneumoniae carbapenemase producing Enterobacteriaceae and multidrug-resistant P. aeruginosa.

AvibactaM Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from AvibactaM manufacturers

shandong perfect biotechnology co.ltd
Product
Avibactam 1192500-31-4
Price
US $0.00/g
Min. Order
1g
Purity
98% HPLC
Supply Ability
1kg
Release date
2023-08-02
Hebei Best Biological Technology Co., Ltd
Product
Avibactam 1192500-31-4
Price
US $200.00/g
Min. Order
10g
Purity
99%
Supply Ability
1000t/month
Release date
2022-11-22
Hebei Mingeng Biotechnology Co., Ltd
Product
Avibactam 1192500-31-4
Price
US $200.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000kg/Months
Release date
2022-11-20

1192500-31-4, AvibactaMRelated Search:


  • AvibactaM
  • Sulfuric acid mono[(1R,2S,5R)-2-(aminocarbonyl)-7-oxo-1,6-diazabicyclo[3.2.1]oct-6-yl] ester
  • (E)-7-fluoro-3-methylhept-4-en-2-one
  • Avibactam free acid
  • AVIBACTAM FREE ACID (NXL-104 FREE ACID)
  • Avibactam Impurity 37
  • Avibactam,(2S,5R)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carbox amide
  • (2S,5R)-2-carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-ylhydrogensulfate
  • (2S,5R)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-carbox amide
  • EOS-60408
  • Avibactam acid
  • NXL-104 free acid
  • (2S,5R)-7-Oxo-6-(sulfooxy)-1,6-diazabicyclo[3.2.1]octane-2-c...
  • (1R,2S,5R)-2-Carbamoyl-7-oxo-1,6-diazabicyclo[3.2.1]octan-6-yl hydrogen sulfate
  • 1192500-31-4
  • C7H11N3O6S