N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE
- Product Name
- N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE
- CAS No.
- 127917-66-2
- Chemical Name
- N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE
- Synonyms
- RO 41-1049 HYDROCHLORIDE;Ro 411049 hydrochloride,Ro 41 1049 hydrochloride;N-(2-Aminoethyl)-5-(3-fluorophenyl)thiazole-4-carboxamide hydrochloride;N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE
- CBNumber
- CB0258423
- Molecular Formula
- C12H13ClFN3OS
- Formula Weight
- 301.76
- MOL File
- Mol file
N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE Property
- storage temp.
- Store at -20°C
- solubility
- H2O: soluble
- form
- solid
- color
- white
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- CS-5591
- Product name
- Ro41-1049(hydrochloride)
- Purity
- 99.96%
- Packaging
- 5mg
- Price
- $72
- Updated
- 2021/12/16
- Product number
- CS-5591
- Product name
- Ro41-1049(hydrochloride)
- Purity
- 99.96%
- Packaging
- 10mg
- Price
- $108
- Updated
- 2021/12/16
- Product number
- CS-5591
- Product name
- Ro41-1049(hydrochloride)
- Purity
- 99.96%
- Packaging
- 50mg
- Price
- $288
- Updated
- 2021/12/16
- Product number
- CS-5591
- Product name
- Ro41-1049(hydrochloride)
- Purity
- 99.96%
- Packaging
- 100mg
- Price
- $480
- Updated
- 2021/12/16
- Product number
- CD31004006
- Product name
- Ro41-1049hydrochloride
- Purity
- 98+%
- Packaging
- 100mg
- Price
- $312
- Updated
- 2021/12/16
N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
Ro 41-1049 hydrochloride is a reversible and selective inhibitor of monoamine oxidase-A (MAO-A). An homogeneous population of high affinity binding sites for [3H]Ro 41-1049 is found in membrane preparations from human frontal cortex and placenta (Kd values of 16.5 and 64.4 nM, respectively)[1].
in vivo
Ro 41-1049 (1-50 mg/kg; intraperitoneal injection; for 3 hours; Sprague-Dawley rats) treatment inhibits dopamine metabolite formation and increases dopamine levels in a dose-dependent fashion. Pretreatment with Ro 41-1049 (20 mg/kg) significantly increases dopamine formation following L-dopa administration (100 mg/kg IP) while decreasing formation of 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA)[2].
| Animal Model: | Sprague-Dawley rats (200-240 g)[2] |
| Dosage: | 1 mg/kg, 5 mg/kg, 10 mg/kg, 20 mg/kg, or 50 mg/kg |
| Administration: | Intraperitoneal injection; for 3 hours |
| Result: | Inhibited dopamine metabolite formation and increased dopamine levels in a dose-dependent fashion. Pretreatment with the concentration of 20 mg/kg significantly increased dopamine formation following L-dopa administration while decreasing formation of DOPAC and HVA. |
References
[1] Cesura AM, et al. Characterization of the binding of [3H]Ro 41-1049 to the active site of human monoamine oxidase-A. Mol Pharmacol. 1990 Mar;37(3):358-66. PMID:2314388
[2] Brannan T, et al. Effect of a selective MAO-A inhibitor (Ro 41-1049) on striatal L-dopa and dopamine metabolism: an in vivo study. J Neural Transm Park Dis Dement Sect. 1994;8(1-2):99-105. DOI:10.1007/BF02250920
N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
N-(2-AMINOETHYL)-5-(3-FLUOROPHENYL)-4-THIAZOLECARBOXAMIDE HYDROCHLORIDE Suppliers
- Tel
- --
- Fax
- --
- Country
- Switzerland
- ProdList
- 6896
- Advantage
- 91