ChemicalBook > CAS DataBase List > (2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate)

(2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate)

Product Name: (2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate)
CAS No.: 940908-79-2
Chemical Name: (2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate)
Synonyms: R 7128;RG 7128;Mericitabine;Mericitabine/RG7128;Mericitabine，R-7128;R-7128(Mericitabine);PSI 6130 diisobutyrate;Mericitabine, 10 mM in DMSO;RG 7128; MERICITABINE; PSI 6130 DIISOBUTYRATE;(2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate)
CBNumber: CB02589653
Molecular Formula: C18H26FN3O6
Formula Weight: 399.41
MOL File: 940908-79-2.mol

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(2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate) Property

Boiling point:: 496.1±55.0 °C(Predicted)
Density: 1.36
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: Powder
pka: 4.26±0.10(Predicted)
color: White to off-white
InChIKey: MLESJYFEMSJZLZ-MAAOGQSESA-N
SMILES: C(OC(=O)C(C)C)[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@@](F)(C)[C@@H]1OC(=O)C(C)C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0596
Product name: Mericitabine
Purity: 99.47%
Packaging: 5mg
Price: $270
Updated: 2021/12/16

ApexBio Technology

Product number: A3747
Product name: R-7128
Packaging: 5mg
Price: $355
Updated: 2021/12/16

ChemScene

Product number: CS-0596
Product name: Mericitabine
Purity: 99.47%
Packaging: 10mg
Price: $367
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0014097
Product name: R7-128
Purity: 95.00%
Packaging: 250MG
Price: $475.65
Updated: 2021/12/16

ApexBio Technology

Product number: A3747
Product name: R-7128
Packaging: 10mg
Price: $483
Updated: 2021/12/16

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(2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate) Chemical Properties,Usage,Production

Uses

Mericitabine (RG 7128; R-7128) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication.

Biological Activity

r-7128 is a selective nucleoside analog inhibitor of the hepatitis c virus (hcv) ns5b rna-dependent rna polymerase.hepatitis c virus (hcv) is an enveloped (+)-single stranded rna virus, and the viral rna is replicated in host cell via hcv's rna-dependent rna polymerase, which is the cause of hepatitis c and some cancer lymphomas.r-7128 is a nucleotide triphosphate analog which is the substrate for hcv polymerase ns5b. incorporation of r-7128 into nascent hcv rna strongly decreased the efficiency of rna elongation by rna polymerase ns5b, leading to the termination of the nascent rna product. it has been shown that r-7128 is able to inhibit the rna synthesis of hcv in vitro [1].32 patient infected with hcv genotype-1 was treated with r-7128 for 14 days with 750-mg or 1500-mg administered once (qd) or twice daily (bid), and the hcv rna level was frequently measured. initial decline of hcv rna was generally slower than treatment with interferon-alpha or protease inhibitors but 12 patients showed a novel pattern of hcv rna kinetics that the effectiveness in inhibiting viral production gradually increased over time to reach its final value. the final value was high with bid dose (mean 750-mg and 1500-mg: 98.0% and 99.8%, p=0.018) and significantly higher than in patients treated qd (mean qd vs bid: 90% vs 99%, p<10^-7) [2].

target

HCV

References

[1] ma h et al. , characterization of the metabolic activation of hepatitis c virus nucleoside inhibitor β-d-2′-deoxy-2′-fluoro-2′-c-methylcytidine (psi-6130) and identification of a novel active 5′-triphosphate species. j biol chem. 2007, 282(41): 29812-20.
[2] guedj j et al. , hepatitis c viral kinetics with the nucleoside polymerase inhibitor mericitabine (rg7128). hepatology. 2012, 55(4): 1030-1037.

(2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate) Preparation Products And Raw materials

Raw materials

Preparation Products

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940908-79-2, (2'R)- 2'-Deoxy-2'-fluoro-2'-methylcytidine 3',5'-bis(2-methylpropanoate)Related Search:

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C18H26FN3O6